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Fexaramine

Fexaramine Structure
Fexaramine structure
CAS No.
574013-66-4
Chemical Name:
Fexaramine
Synonyms
CS-1691;Depasan;Actospar;Fexaramine;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr;(E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester;2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(diMethylaMino)[1,1'-biphenyl]-4-yl]Methyl]aMino]phenyl]-, Methyl ester
CBNumber:
CB31074393
Molecular Formula:
C32H36N2O3
Molecular Weight:
496.64
MDL Number:
MFCD09971007
MOL File:
574013-66-4.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
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Fexaramine Properties

Boiling point 677.7±55.0 °C(Predicted)
Density 1.158±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : 50 mg/mL (100.68 mM; Need ultrasonic)
pka 4.95±0.24(Predicted)
form powder
color white to beige
FDA UNII WTG9GFA65U

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H413
Precautionary statements  P273-P301+P312+P330
NFPA 704
0
2 0

Fexaramine price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1390 Fexaramine ≥98% (HPLC) 574013-66-4 5MG $142 2023-06-20 Buy
Sigma-Aldrich SML1390 Fexaramine ≥98% (HPLC) 574013-66-4 25MG $564 2023-06-20 Buy
Cayman Chemical 17369 Fexaramine ≥98% 574013-66-4 1mg $32 2024-03-01 Buy
Cayman Chemical 17369 Fexaramine ≥98% 574013-66-4 5mg $122 2024-03-01 Buy
Cayman Chemical 17369 Fexaramine ≥98% 574013-66-4 10mg $199 2024-03-01 Buy
Product number Packaging Price Buy
SML1390 5MG $142 Buy
SML1390 25MG $564 Buy
17369 1mg $32 Buy
17369 5mg $122 Buy
17369 10mg $199 Buy

Fexaramine Chemical Properties,Uses,Production

Description

The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (; EC50 = 80 nM). Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.

Uses

Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis in mouse model.

Definition

ChEBI: Fexaramine is a member of biphenyls.

General Description

Fexaramine belongs to the nuclear hormone receptor family.

Biological Activity

Potent, selective farnesoid X receptor agonist (EC 50 = 25 nM). Displays no activity at hRXR α , hPPAR α , hPPAR γ , hPPAR δ , mPXR, hPXR, hLXR α , hTR β , hRAR β , mCAR, mERR γ and hVDR receptors.

Biochem/physiol Actions

Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.

storage

Desiccate at +4°C

Fexaramine Preparation Products And Raw materials

Raw materials

Preparation Products

Fexaramine Suppliers

Global( 92)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9571 58
Henan Alfa Chemical Co., Ltd 		+8618339805032 alfa4@alfachem.cn China 12756 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58
Finetech Industry Limited 		58
Henan Alfa Chemical Co., Ltd 		58
Labnetwork lnc. 		58
InvivoChem 		58

View Lastest Price from Fexaramine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fexaramine pictures 2019-09-06 Fexaramine
574013-66-4
 US $1.00 / KG 1KG 98% 20kg Career Henan Chemical Co
  • Fexaramine pictures
  • Fexaramine
    574013-66-4
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

Fexaramine Spectrum

Fexaramine(574013-66-4)1HNMR

574013-66-4(Fexaramine)Related Search:

RGB-286638 (free base) GSK2141795 SR9009 TD52 BAM15
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide TG4-155 PH 797804 NVP-TAE684 Fexaramine

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Fexaramine 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester 2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(diMethylaMino)[1,1'-biphenyl]-4-yl]Methyl]aMino]phenyl]-, Methyl ester (E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate (2E,4Z)-5-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)-4-(methoxycarbonyl)penta-2,4-dienoic acid 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr 3-[3-[(Cyclohexylcarbonyl)[[4\'-(dimethylamino)[1,1\'-biphenyl]-4-yl]methyl]amino]phenyl]-2-Propenoic acid methyl ester, >98% CS-1691 2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester, (2E)- Actospar Depasan (E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate 574013-66-4 C32H36N2O3 Inhibitors