JP1302
- CAS No.
- 80259-18-3
- Chemical Name:
- JP1302
- Synonyms
- JP1302;MMV006172;Brn 5117597;JP 1302 dihydrochloride;N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine;N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine;9-Acridinamine, N-(4-(4-methyl-1-piperazinyl)phenyl)-;JP1302(9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-);N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinaminedihydrochloride
- CBNumber:
- CB31075143
- Molecular Formula:
- C24H24N4
- Molecular Weight:
- 368.47
- MDL Number:
- MFCD10565599
- MOL File:
- 80259-18-3.mol
| Product description | Number | Pack Size | Price |
| JP1302dihydrochloride ≥99%(HPLC) | 2666 | 10 | $233 |
| JP1302dihydrochloride ≥99%(HPLC) | 2666 | 50 | $980 |
| JP 1302 dihydrochloride | 255566 | 10mg | $480 |
| JP 1302 DIHYDROCHLORIDE 95.00% | API0008021 | 10MG | $727.65 |
| JP1302dihydrochloride | B7147 | 10mg | $338 |
| Boiling point | 550.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.227±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| pka | 9.03±0.10(Predicted) |
| Water Solubility | <44.14mg/ml in Water |
| EWG's Food Scores | 1 |
JP1302 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2666 | JP1302dihydrochloride ≥99%(HPLC) | 80259-18-3 | 10 | $233 | 2021-12-16 | Buy |
| Tocris | 2666 | JP1302dihydrochloride ≥99%(HPLC) | 80259-18-3 | 50 | $980 | 2021-12-16 | Buy |
| Usbiological | 255566 | JP 1302 dihydrochloride | 80259-18-3 | 10mg | $480 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008021 | JP 1302 DIHYDROCHLORIDE 95.00% | 80259-18-3 | 10MG | $727.65 | 2021-12-16 | Buy |
| ApexBio Technology | B7147 | JP1302dihydrochloride | 80259-18-3 | 10mg | $338 | 2021-12-16 | Buy |
JP1302 Chemical Properties,Uses,Production
Uses
JP 1302 Dihydrochloride is an α2-adrenoceptor blocker and can be used for the treatment or prevention of nephropathy.
Biological Activity
α 2C -adrenoceptor antagonist that displays ~ 50-fold selectivity over other α 2 -adrenoceptor subtypes (K i values are 28, 1470, 1700 and 3150 nM for human α 2C , α 2B , α 2D and α 2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35 GTP γ S binding in vitro (K B = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo .
in vivo
JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine.html" class="link-product" target="_blank">Desipramine (HY-B1272A)[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction[3].
| Animal Model: | Male Sprague Dawley rats (8 weeks old)[3] |
| Dosage: | 3 mg/kg |
| Administration: | IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion |
| Result: | Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression. |
IC 50
human α2C-adrenoceptor: 28±2 nM (Ki); human α2B-adrenoceptor: 1470±130 nM (Ki); human α2A-adrenoceptor: 3150±50 nM (Ki); rodent α2D-adrenoceptor: 1700±200 nM (Ki)
JP1302 Preparation Products And Raw materials
Raw materials
Preparation Products
JP1302 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4764 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 981 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6897 | 55 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2986 | 58 |
