ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-

Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-

Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- structure

CAS No.: 1628048-93-0

Chemical Name:: Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-

Synonyms: SGK1-IN-4;SGK1-IN-4 (compound 17a);Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-;Serum and glucocorticoid-regulated kinase,SGK,Serum-glucocorticoid regulated kinase,SGK1 IN 4,osteoarthritis,Inhibitor,orally active,SGK1 inhibitor,SGK1IN4,inhibit

CBNumber:: CB311116364

Molecular Formula:: C23H21ClFN5O4S

Molecular Weight:: 517.96

MDL Number:

MOL File:: 1628048-93-0.mol

Last updated:2023-04-23 13:52:06

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Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- Properties

Density	1.543±0.06 g/cm3(Predicted)
solubility	DMSO : 250 mg/mL (482.66 mM; Need ultrasonic)
pka	5.76±0.10(Predicted)

Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- Chemical Properties,Uses,Production

Biological Activity

SGK1-IN-4 (compound 17a) is a highly selective, orally active SGK1 inhibitor. SGK1-IN-4 can be used for osteoarthritis research[1].

References

[1]. Nis Halland, et al. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem. 2022 Jan 27;65(2):1567-1584.

Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4196	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9838	58
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	chaolaichem@foxmail.com	China	9242	58
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	502	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	997	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Shanghai SuperLan Chemcial Technique Centre	58
Shanghai Yu Ben Biotechnology Co., Ltd.	58
DC Chemicals	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58

Benzenesulfonamide, 5-chloro-2-fluoro-N-[4-[4-[(trans-4-hydroxycyclohexyl)oxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]- SGK1-IN-4 (compound 17a) SGK1-IN-4 Serum and glucocorticoid-regulated kinase,SGK,Serum-glucocorticoid regulated kinase,SGK1 IN 4,osteoarthritis,Inhibitor,orally active,SGK1 inhibitor,SGK1IN4,inhibit 1628048-93-0