6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- CAS No.
- 75680-92-1
- Chemical Name:
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- Synonyms
- 6-chlorodazine-3-ethyl formate;ethyl 4-chloropyriMidine-2-carboxylate;Ethyl 6-chloropyridazine-3-carboxylate;Ethyl 6-chloro-3-pyridazinecarboxylate;6-Chloro-pyridazine-3-carboxylic acid ethyl ester;3-Pyridazinecarboxylic acid, 6-chloro-, ethyl ester;6-Chloro-pyridazine-3-carboxylic acid ethyl ester ISO 9001：2015 REACH
- CBNumber:
- CB31113382
- Molecular Formula:
- C7H7ClN2O2
- Molecular Weight:
- 186.6
- MDL Number:
- MFCD09908168
- MOL File:
- 75680-92-1.mol
| Product description | Number | Pack Size | Price |
| Ethyl6-chloropyridazine-3-carboxylate | E903558 | 250mg | $55 |
| Ethyl6-chloro-3-pyridazinecarboxylate | W8288 | 1g | $141 |
| 6-Chloro-pyridazine-3-carboxylic acid ethyl ester | FC59739 | 1g | $150 |
| 6-CHLORO-PYRIDAZINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00% | HCH0006754 | 1G | $490 |
| 6-Chloro-pyridazine-3-carboxylic acid ethyl ester | FC59739 | 10g | $550 |
| More product size | |||
| Melting point | 147-149 °C |
|---|---|
| Boiling point | 320.1±22.0 °C(Predicted) |
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Crystalline Powder |
| pka | -0.94±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C7H7ClN2O2/c1-2-12-7(11)5-3-4-6(8)10-9-5/h3-4H,2H2,1H3 |
| InChIKey | GVSVPKDEHFOXSW-UHFFFAOYSA-N |
| SMILES | C1(C(OCC)=O)=NN=C(Cl)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HS Code | 29339980 |
6-Chloro-pyridazine-3-carboxylic acid ethyl ester price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E903558 | Ethyl6-chloropyridazine-3-carboxylate | 75680-92-1 | 250mg | $55 | 2021-12-16 | Buy |
| AK Scientific | W8288 | Ethyl6-chloro-3-pyridazinecarboxylate | 75680-92-1 | 1g | $141 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC59739 | 6-Chloro-pyridazine-3-carboxylic acid ethyl ester | 75680-92-1 | 1g | $150 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0006754 | 6-CHLORO-PYRIDAZINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00% | 75680-92-1 | 1G | $490 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC59739 | 6-Chloro-pyridazine-3-carboxylic acid ethyl ester | 75680-92-1 | 10g | $550 | 2021-12-16 | Buy |
6-Chloro-pyridazine-3-carboxylic acid ethyl ester Chemical Properties,Uses,Production
Uses
Ethyl 6-Chloropyridazine-3-carboxylate is a useful research chemical compound used in the preparation of hetero-substituted pyridazine derivatives using alkylation of chloropyridazinecarboxylate followed by cross-coupling and heterocyclization.
Synthesis
63001-31-0
75680-92-1
Ethyl 3-pyridazinone-6-carboxylate (1.17 g, 6.96 mmol) was used as a raw material, which was dissolved in phosphoryl chloride (12 mL) and the reaction was heated at 100 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to about 3 mL. The concentrated residue was slowly poured into ice water and slowly neutralized with 10% aqueous sodium hydroxide solution under ice bath conditions. The neutralized mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution and subsequently dried with anhydrous magnesium sulfate. The dried organic phase was evaporated under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel (200-300 mesh, eluent ratio hexane: ethyl acetate = 3:1) to afford ethyl 6-chloropyridazine 3-carboxylate (892 mg, yield 68.7%) as a white solid. The melting point was measured to be 145.6-146.7 °C (literature values 154-155 °C [56]).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 598 - 611
[2] Patent: CN106187910, 2016, A. Location in patent: Paragraph 0242; 0243
[3] Nippon Kagaku Zasshi, 1957, vol. 78, p. 577,579, 580
[4] Chem.Abstr., 1959, p. 5275
[5] Bulletin de la Societe Chimique de France, 1959, p. 1793,1796
6-Chloro-pyridazine-3-carboxylic acid ethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13619 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29837 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2161 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 6-Chloro-pyridazine-3-carboxylic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
75680-92-1
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-10-13 | ethyl 6-chloropyridazine-3-carboxylate
75680-92-1
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2022-08-13 | 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
75680-92-1
|
US $0.00-0.00 / G | 1G | 99%minHPLC | 100kgs/month | Shanghai Rlavie Technology Co ltd |
-
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
75680-92-1
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- ethyl 6-chloropyridazine-3-carboxylate
75680-92-1
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
75680-92-1
- US $0.00-0.00 / G
- 99%minHPLC
- Shanghai Rlavie Technology Co ltd
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