ChemicalBook >> CAS DataBase List >>Nepicastat
Nepicastat
- CAS No.
- 173997-05-2
- Chemical Name:
- Nepicastat
- Synonyms
- SYN117;CS-853;Nepitat;Nepicastat;RS-25560-197;Nepicastat HCl;Nepicastat [inn];Nepicastat (SYN 117);Nepicastat (free base) (SYN-117);SYN117;RS-25560-197;SYN-117;SYN 117
- CBNumber:
- CB31116989
- Molecular Formula:
- C14H15F2N3S
- Molecular Weight:
- 295.35
- MDL Number:
- MFCD09837766
- MOL File:
- 173997-05-2.mol
Last updated:2023-07-12 16:33:55
| Boiling point | 401.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.40 |
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 48 mg/mL (162.52 mM) |
| form | Powder |
| pka | 11.69±0.70(Predicted) |
| FDA UNII | VPG12K4540 |
Nepicastat price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 474143 | Nepicastat | 173997-05-2 | 100mg | $1890 | 2021-12-16 | Buy |
| Matrix Scientific | 093133 | (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thione 95+% | 173997-05-2 | 250mg | $5670 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000869 | NEPICASTAT 95.00% | 173997-05-2 | 250MG | $8610 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000869 | NEPICASTAT 95.00% | 173997-05-2 | 1G | $9435.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000869 | NEPICASTAT 95.00% | 173997-05-2 | 10MG | $1006.58 | 2021-12-16 | Buy |
Nepicastat Chemical Properties,Uses,Production
Uses
Treatment of congestive heart failure (dopamine β-hydroxylase inhibitor).
Definition
ChEBI: Nepicastat is a member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has a role as an EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor. It is a member of tetralins, an organofluorine compound, a primary amino compound and a member of 1,3-dihydroimidazole-2-thiones.
target
DBH
Nepicastat Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15746 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from Nepicastat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-08 | Nepicastat
173997-05-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-13 | Nepicastat
173997-05-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Nepicastat
173997-05-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Nepicastat
173997-05-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Nepicastat
173997-05-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Nepicastat
173997-05-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
Nepicastat
Nepicastat [inn]
5-(AMinoMethyl)-1-((S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthyl)-4-iMidazoline-2-thione
5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione
RS-25560-197
SYN117
Nepicastat (free base) (SYN-117)
Nepicastat HCl
(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thione
(S)-5-Aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-2,3-dihydro-2-thioxo-1H-imidazole Hydrochloride
(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thi
Nepitat
SYN117;RS-25560-197;SYN-117;SYN 117
CS-853
Nepicastat (SYN 117)
2H-Imidazole-2-thione, 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-
173997-05-2
C14H15F2N3S
API