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Coumarin

Brief Introduction Chemical Properties Uses
Coumarin
Coumarin structure
CAS No.
91-64-5
Chemical Name:
Coumarin
Synonyms
Rattex;CUMARIN;Kumarin;COUMARIN;NSC 8774;ncic07103;COUMARINE;NCI C07103;AKOS 212-75;COUMARIN(P)
CBNumber:
CB3112168
Molecular Formula:
C9H6O2
Formula Weight:
146.14
MOL File:
91-64-5.mol

Coumarin Properties

Melting point:
68-73 °C(lit.)
Boiling point:
298 °C(lit.)
Density 
0.935
vapor pressure 
0.01 mm Hg ( 47 °C)
refractive index 
1.5100 (estimate)
Flash point:
162 °C
storage temp. 
Refrigerator
solubility 
1.7g/l
form 
Crystals or Crystalline Powder
color 
White
PH Range
Non' uorescence (9.5) to light green ' uorescence (10.5)
Water Solubility 
1.7 g/L (20 ºC)
λmax
275nm
Merck 
14,2562
BRN 
383644
Major Application
color filter, organic electroluminescent devices, liquid crystal displays, field emission displays, inks, nickel plating, detergents, deodorant for shoes, petroleum products, cigarettes, personal care products, cosmetics, sunscreen cream, perfumes, nucleic acid sequencing, antiinflammatory agent, treatment of cancer, neurotransmission disorders, bleeding disorders, cerebrovascular disease, thrombosis, hemorrhoids, rheumatic disease, arthritic disease, epilepsy, vaginitis, painkiller, teeth whitening agent, skin whitening agent, wound healing promoter
InChIKey
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
CAS DataBase Reference
91-64-5(CAS DataBase Reference)
NIST Chemistry Reference
Coumarin(91-64-5)
EPA Substance Registry System
2H-1-Benzopyran- 2-one(91-64-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-40-36/37/38-20/21/22-43
Safety Statements  36-36/37-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  1
RTECS  GN4200000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29322010
Hazardous Substances Data 91-64-5(Hazardous Substances Data)
Toxicity LD50 orally in rats, guinea pigs: 680, 202 mg/kg (Jenner)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Coumarin price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 01260595 Coumarin primary reference standard 91-64-5 50mg $218 2018-11-13 Buy
Sigma-Aldrich 72609 Coumarin certified reference material, TraceCERT 91-64-5 100mg $82.4 2018-11-13 Buy
TCI Chemical C0395 Coumarin >99.0%(GC) 91-64-5 25g $17 2018-11-22 Buy
TCI Chemical C0395 Coumarin >99.0%(GC) 91-64-5 500g $66 2018-11-22 Buy
Alfa Aesar A15336 Coumarin, 98% 91-64-5 250g $45.9 2018-11-13 Buy

Coumarin Chemical Properties,Uses,Production

Brief Introduction


It is also known as 1, 2-benzopyrone, cis ortho-caberillin, o-hydroxy cinnamon lactone and coumarin. It is contained in many natural plants in the form of glycosides and esters as vanillin instead of free-form. Coumarin will come out when certain plants are fermented and processed. Coumarin is found in the seeds of Dayton beans (Riccinechoides) in 1820 and is widely distributed in the plant kingdom, especially in plant species including Umbelliferae, Soybean, Rutaceae and Calyx. Seeds contain about 1.5% of the coumarin. In addition, coumarin is also contained in lavender oil, cinnamon oil and Peru balsam. Coumarin is spicy with sweet and lemongrass aroma. The aroma is emitted from the pink gum in the leaves of the fragrant beans, and the gum is made from the breakdown of the coumarin glycosides in the leaves. The aroma emitted by Sweet alfalfa is actually from the release of coumarin due to fermentation and decomposition during the stacking process. Precipitate from the ether appears as orthorhombic white pyramid or oblique sheet-like crystals with Lemongrass-type smell. It can subject to sublimation.

Chemical Properties

Golden crystalline solid (fronds or rhomboid); it is sweet with black beans-like aroma, dried herbs aroma and fennel aroma. After dilution, it smells like dried straw, nuts and tobacco. It is insoluble in cold water but soluble in hot water, ethanol and chloroform, easily soluble in ether and benzene. The solubility in 100ml of water at 25 ℃ is only 0.01g; 13 7g in 100ml of ethanol at 16 ℃; 1g in 50 mL 100℃ hot water. Oral LD50: 680mg / kg for rat.

Uses

used as a spice for the preparation of floral fragrances such as lavender, rosemary and rosemary, used in perfumes, cosmetics, soaps and detergents; used as flavoring agents for blending fragrances to make the aroma be lasting and unchanged; used as an electroplating additive to prevent the occurrence of pores in coating and can increase the brightness; as the flavor enhancer of printing ink and plastic; formerly used as spices and cigarettes spices, banned from 197; Since then, China had also prohibited it application in food; used as pharmaceutical raw materials.
Coumarin, as a laser dye, has an output laser range be within the blue-green region (420 ~ 570nm), has high fluorescence quantum efficiency, such as 7-ethylamino-6-methyl-4-trifluoromethyl coumarin Lactone 307), the structure is as follows:

Chemical Properties

Coumarin occurs widely in nature and determines, for example, the odor of woodruff. It forms white crystals (mp 70.6°C) with a hay-like, spicy odor. When treated with dilute alkali, coumarin is hydrolyzed to the corresponding coumarinic acid salt [(Z)-2-hydroxycinnamic acid]. Heating with concentrated alkali or with sodium ethanolate in ethanol results in the formation of o-coumaric acid salts [(E)-2-hydroxycinnamic acid]. 3,4-Dihydrocoumarin is obtained by catalytic hydrogenation, for example, with Raney nickel as a catalyst; octahydrocoumarin is obtained if hydrogenation is carried out at high temperature (200–250°C).

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Uses

Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.

Uses

antineoplastic, antiinflammatory, antihyperglycaemic

Uses

coumarin is considered a blood thinner, it can also increase blood flow. Some sources cite anti-oxidant capacities, as well. It is a specific plant constituent and is what creates the fragrance of freshly mowed hay. Coumarin is found in such plants as cherries, lavender, licorice, and sweet clover.

Preparation

Coumarin is currently produced by Perkin synthesis from salicylaldehyde. In the presence of sodium acetate, salicylaldehyde reacts with acetic anhydride to produce coumarin and acetic acid. The reaction is carried out in the liquid phase at elevated temperature.
A process for the production of coumarin from hexahydrocoumarin by dehydrogenation has also been elaborated.
Since the odor of coumarin is relatively weak, strong-smelling by-products (e.g., vinylphenol) must be removed. Many purification methods have been reported and patented.

Definition

ChEBI: A chromenone having the keto group located at the 2-position.

Definition

A colorless crystalline compound with a pleasant odor, used in making perfumes. On hydrolysis with sodium hydroxide it forms coumarinic acid.

General Description

Colorless crystals, flakes or colorless to white powder with a pleasant fragrant vanilla odor and a bitter aromatic burning taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Coumarin is sensitive to exposure to light. Coumarin is also sensitive to heat. Coumarin is incompatible with strong acids, strong bases and oxidizers. Coumarin is hydrolyzed by hot concentrated alkalis. Coumarin can be halogenated, nitrated and hydrogenated (in the presence of catalysts).

Hazard

Toxic by ingestion; carcinogenic. Use in food products prohibited (FDA). Questionable carcinogen.

Health Hazard

SYMPTOMS: Exposure to Coumarin may cause narcosis. It may also cause irritation and liver damage.

Fire Hazard

Coumarin is combustible.

Contact allergens

Coumarin is an aromatic lactone naturally occurring in Tonka beans and other plants. As a fragrance allergen, it has to be mentioned by name in cosmetics within the EU

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data. Experimental teratogenic effects. Mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes. See also KETONES and ANHYDRIDES.

Purification Methods

Coumarin crystallises from ethanol or water and sublimes in vacuo at 43o [Srinivasan & deLevie J Phys Chem 91 2904 1987]. [Beilstein 17/10 V 143.]

Coumarin Preparation Products And Raw materials

Raw materials

Preparation Products


Coumarin Suppliers

Global( 360)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19947 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3210 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32606 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1747 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20177 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 940 58

View Lastest Price from Coumarin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Coumarin
91-64-5
US $1.00 / kg 1g 99% 100KG career henan chemical co
2019-04-29 Coumarin
91-64-5
US $10.00 / KG 1KG 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.

Coumarin Spectrum


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