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2'-C-Methyladenosine

2'-C-Methyladenosine structure

CAS No.: 15397-12-3

Chemical Name:: 2'-C-Methyladenosine

Synonyms: -C-Methyladenosine;2'-C-Methyladenosine;2'-C-Methyladenosine;2’-b-C-Methyladenosine;2’-β-C-Methyladenosine;2'-CMethyl-D-adenosine;Adenosine, 2'-C-methyl-;2'-C-Methyladenosine USP/EP/BP;2’-b-C-Methyladenosine, HCV and antiviral agent;6-Amino-9-(2'-C-methyl-b-D-ribofuranosyl)purine

CBNumber:: CB31177964

Molecular Formula:: C11H15N5O4

Molecular Weight:: 281.27

MDL Number:: MFCD02682944

MOL File:: 15397-12-3.mol

Last updated:2023-05-21 10:59:17

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2'-C-Methyladenosine Properties

Boiling point	643.4±65.0 °C(Predicted)
Density	1.89
storage temp.	Store at -20°C
solubility	DMF: 5 mg/mL; DMSO: 20 mg/mL; PBS (pH 7.2): 10 mg/mL
form	A crystalline solid
pka	13.18±0.70(Predicted)

2'-C-Methyladenosine price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23062	2'-C-Methyladenosine ≥98%	15397-12-3	50mg	$231	2024-03-01	Buy
Cayman Chemical	23062	2'-C-Methyladenosine ≥98%	15397-12-3	100mg	$436	2024-03-01	Buy
Medical Isotopes, Inc.	C107863	2?-C-Methyladenosine	15397-12-3	250mg	$550	2021-12-16	Buy
Biosynth Carbosynth	NM07917	2'-C-Methyladenosine	15397-12-3	250mg	$150	2021-12-16	Buy
AK Scientific	3659CC	2'-C-Methyladenosine	15397-12-3	100mg	$164	2021-12-16	Buy

Product number	Packaging	Price	Buy
23062	50mg	$231	Buy
23062	100mg	$436	Buy
C107863	250mg	$550	Buy
NM07917	250mg	$150	Buy
3659CC	100mg	$164	Buy

2'-C-Methyladenosine Chemical Properties,Uses,Production

Description

2′-C-Methyladenosine has been shown to inhibit HCV RNA replication in the absence of cytotoxicity. The corresponding triphosphates were shown to be potent, competitive inhibitors of NS5B-catalyzed reactions in vitro.

Biological Activity

2’-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 μM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 μM.{39652} It is converted intracellularly to adenosine triphosphate, which inhibits the RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). It also inhibits growth of L. guyanensis in vitro (EC50 = 3 μM) and eradicates it when used at a concentration of 10 μM.

Synthesis

Synthesis_15397-12-3
Synthesis of yfl-2'-methyl-adenosine (CHCl); N6-tert-butanoyl-/?-2'-methyl-2',3',5'-tribenzoyl-adenosine (400 mg, 0.590 mmol) was added to a solution of MeOH saturated with ammonia, and stirred at room temperature. After 12 hours the solvent was removed and the obtained solid was purified by column chromatography in gradient starting with a mixture of CHCl3/MeOH 9:1 then 8:2. The pure product was obtained as a white solid (120 mg, 0.427 mmol, 72%). |?H (J6-DMSO): 8.47 (IH, s, H8-adenosine), 8.15 (IH, s, H2-adenosine), 7.30 (IH, s, NH26-adenosine), 5.95 (IH, s, Hl '-adenosine), 5.25-5.21 (3H, m, OH5' -adenosine, OH3'- adenosine, OH2' -adenosine), 4.12-4.05 (IH, d, H3 '-adenosine, J= 8.6 Hz), 3.91 (IH, m, H4'-adenosine), 3.84 (IH, m, H5' -adenosine), 3.70 (IH, m, H5' -adenosine), 0.77 (3H3 s, CH32'-adenosine); |?c (4-DMSO): 156.02 (1C, C6-adenosine), 152.53 (1C, C2-adenosine), 149.01 (1C, C4-adenosine), 138.68 (1C, C8-adenosine), 118.67 (1C, C5-adenosine), 90.78 (1C, Cl '-adenosine), 82.52 (1C, C4' -adenosine), 78.46 (1C, C2'-adenosine), 71.63 (1C, C3' -adenosine), 59.47 (1C, C5 '-adenosine), 19.83 (1C, CH3-2'-adenosine). Anal. CaIc. for C11H15N5O4: C 46.97%, H 5.38%, N 24.90%. Found: C 46.67%, H 5.22%, N 24.20%.

2'-C-Methyladenosine synthesis

Synthesis of 2'-C-Methyladenosine from 6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-beta-D-ribofuranosyl)-9H-purine

2'-C-Methyladenosine Preparation Products And Raw materials

Raw materials

6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-beta-D-ribofuranosyl)-9H-purine

Preparation Products

2'-C-Methyladenosine Suppliers

Global( 66)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10027	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58

Supplier	Advantage
NewCan Biotech Limited	58
Hangzhou FandaChem Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
Nanjing Baifuli Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Dideu Industries Group Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58

15397-12-3(2'-C-Methyladenosine)Related Search:

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6-Amino-9-(2'-C-methyl-b-D-ribofuranosyl)purine 2'-CMethyl-D-adenosine Adenosine, 2'-C-methyl- 2'-C-Methyladenosine -C-Methyladenosine 2-(6-AMINOPURIN-9-YL)-5-(HYDROXYMETHYL)-3-METHYLOXOLANE-3,4-DIOL (2R,3R,4R,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol 2’-β-C-Methyladenosine 2'-C-Methyladenosine USP/EP/BP 2’-b-C-Methyladenosine, HCV and antiviral agent 2’-b-C-Methyladenosine 2'-C-Methyladenosine 15397-12-3