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Tiazofurine

CAS No.
60084-10-8
Chemical Name:
Tiazofurine
Synonyms
TCAR;CI 909;Aids014479;tiazofurin;Riboxamide;NSC-286193;Aids-014479;NSC-286-193;Tiazofurine;Tiazofurinum
CBNumber:
CB31179908
Molecular Formula:
C9H12N2O5S
Molecular Weight:
260.269
MDL Number:
MFCD00866494
MOL File:
60084-10-8.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:19

Tiazofurine Properties

Melting point 145-146°
alpha D25 -9° (c = 0.5 in ethanol)
Density 1.4797 (rough estimate)
refractive index 1.6800 (estimate)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form Solid
color White to Pale Beige
Stability Very Very Hygroscopic
NCI Dictionary of Cancer Terms tiazofurin
FDA UNII ULJ82834RE
NCI Drug Dictionary Riboxamide
ATC code L01XX18

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Tiazofurine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 295002 Tiazofurin 60084-10-8 2mg $486 2021-12-16 Buy
TRC T437200 Tiazofurin 60084-10-8 25mg $795 2021-12-16 Buy
TRC T437200 Tiazofurin 60084-10-8 50mg $1390 2021-12-16 Buy
AK Scientific 8957AB 2-b-D-Ribofuranosyl-4-thiazolecarboxamide 60084-10-8 25mg $1553 2021-12-16 Buy
American Custom Chemicals Corporation API0009152 TIAZOFURIN 95.00% 60084-10-8 5G $3817.8 2021-12-16 Buy
Product number Packaging Price Buy
295002 2mg $486 Buy
T437200 25mg $795 Buy
T437200 50mg $1390 Buy
8957AB 25mg $1553 Buy
API0009152 5G $3817.8 Buy

Tiazofurine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5'-monophosphate (IMP) dehydrogenase.

Uses

Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5''-monophosphate (IMP) dehydrogenase.

Definition

ChEBI: A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucle tide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).

brand name

Tiazofurine is INN.

23316-67-8
60084-10-8
Synthesis of Tiazofurine from 2,3,5-Tri-O-benzoyl-beta-D-ribofuranosyl cyanide
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NSC-286193 NSC-286-193 Riboxamide TCAR 2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide Tiazofurine tiazofurin Aids014479 Aids-014479 2-β-D-Ribofuranosyl-4-thiazolecarboxaMide 2-β-D-Ribofuranosylthiazole-4-carboxaMide CI 909 2-b-D-Ribofuranosyl-4-thiazolecarboxaMide 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl- 2-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide 2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thiazole-4-carboxamide Nucleoside Antimetabolite/Analog,NSC-286193,Inhibitor,Tiazofurin,inhibit,NSC286193,Orthopoxvirus Tiazofurinum 60084-10-8 Carbohydrates & Derivatives Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds