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Anastrozole

Indications and Usage Clinical Research
Anastrozole
Anastrozole structure
CAS No.
120511-73-1
Chemical Name:
Anastrozole
Synonyms
zd;MDPT;ZD-1033;Anastrol;ARIMIDEX;Astrozole;Anatrozole;Anastrozol;ICI-D-1033;ANASTROZOLE
CBNumber:
CB3121715
Molecular Formula:
C17H19N5
Formula Weight:
293.36626
MOL File:
120511-73-1.mol

Anastrozole Properties

Melting point:
81-82°C
storage temp. 
Store at RT
solubility 
DMSO: soluble40mg/mL
form 
solid
InChIKey
YBBLVLTVTVSKRW-UHFFFAOYSA-N
CAS DataBase Reference
120511-73-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-61-60
Safety Statements  26-37/39
RIDADR  3249
WGK Germany  3
RTECS  CZ1465000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339980
Hazardous Substances Data 120511-73-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Anastrozole price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A2736 Anastrozole ≥98% (HPLC) 120511-73-1 10mg $81.9 2018-11-20 Buy
Sigma-Aldrich 1034807 Anastrozole 120511-73-1 200mg $568.4 2018-11-20 Buy
Cayman Chemical 11987 Anastrozole ≥98% 120511-73-1 10mg $45 2018-11-13 Buy
Cayman Chemical 11987 Anastrozole ≥98% 120511-73-1 50mg $99 2018-11-13 Buy
Sigma-Aldrich Y0001522 Anastrozole European Pharmacopoeia (EP) Reference Standard 120511-73-1 y0001522 $179 2018-11-23 Buy

Anastrozole Chemical Properties,Uses,Production

Indications and Usage

Anastrozole is a potent selective triazole aromatase inhibitor that inhibits the aromatase that cytochrome P-450 is dependent on to prevent the biosynthesis of estrogen. Estrogen is the main stimulating factor for breast cancer cell growth. This drug’s half maximal inhibitory concentration (IC50) value to human placental aromatase is 15nmol/L. Compared to the traditional drug tamoxifen, Anastrozole can comprehensively and effectively lower the risks of breast cancer recurrence and metastasis, thus extending patients’ disease-free survival.
Anastrozole is suitable for treating postmenopausal advanced breast cancer patients, especially postmenopausal advanced breast cancer patients who experienced recurrence following hormone assisted therapy.

Clinical Research

A series of clinical trials compared the effects of third generation aromatase inhibitor Anastrozole with those of tamoxifen. The trial was a global multicenter trial and includes 381 centers in 21 countries. Since 1996, there have been 9366 patients who have participated, and the follow-up time is 100 months. 25.8% of patients in the Anastrozole group experienced recurrence, while 29.9% of patients in the tamoxifen group did. Thus, Anastrozole’s recurrence rate was 4.1% lower than that of tamoxifen, and its risk of distant metastasis was lower as well. Anastrozole is also safer than tamoxifen.

Description

Anastrozole entered its first market in the United Kingdom for the treatment of advanced breast cancer in post-menopausal women. Anastrozole is a highly potent and selective aromatase inhibitor. It is extremely potent in lowering circulating estradiol to undetectable levels in treated patients without altering other circulating hormones. The drug is reportedly well absorbed and tolerated following oral administration.

Chemical Properties

Crystalline Solid

Originator

Zeneca (United Kingdom)

Uses

antiseptic, spermaticide

Uses

An aromatase inhibitor. Used as an antineoplastic.

Definition

ChEBI: A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.

brand name

Arimidex (AstraZeneca).

General Description

Anastrozole,α,α,α',α'-tetramethyl5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile,was the first specific aromatase inhibitor approved in theUnited States. It is indicated for first-line treatment of postmenopausalwomen with advanced or metastatic breast cancer,for second-line treatment of postmenopausal patientswith advanced breast cancer who have had disease progressionfollowing tamoxifen therapy, and for adjuvant treatmentof women with early breast cancer. Patients who did not respondto tamoxifen therapy rarely respond to anastrozole.

Biological Activity

Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.

Anastrozole Preparation Products And Raw materials

Raw materials

Preparation Products


Anastrozole Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
GZ HONCH CHEMICAL TECHNOLOGY CO.,LTD
+8615322315498 skype:live:91c564749a4e2c2c
+8615322315498(whatsApp) honchchem@foxmail.com CHINA 141 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55

View Lastest Price from Anastrozole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Anastrozole
120511-73-1
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-27 Anastrozole
120511-73-1
US $15.00 / KG 1KG 99% 1000KG career henan chemical co
2019-03-25 Arimidex 120511-73-1
120511-73-1
US $1.00-100.00 / kg 10kg 99.9% 1000kg Hebei Jimi Trading Co., Ltd.

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