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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Structure
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide structure
CAS No.
289656-45-7
Chemical Name:
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
Synonyms
Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
CBNumber:
CB31261049
Molecular Formula:
C20H15F2NO
Molecular Weight:
323.34
MDL Number:
MFCD09027349
MOL File:
289656-45-7.mol
Last updated:2023-09-04 16:42:00
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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Properties

Melting point 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
Boiling point 460.7±45.0 °C(Predicted)
Density 1.250±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
form Powder
pka 15.41±0.50(Predicted)
FDA UNII TS6G201A6Q

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29679 Senicapoc 289656-45-7 100mg $57 2024-03-01 Buy
Cayman Chemical 29679 Senicapoc 289656-45-7 1g $426 2024-03-01 Buy
Cayman Chemical 29679 Senicapoc 289656-45-7 50mg $32 2024-03-01 Buy
Cayman Chemical 29679 Senicapoc 289656-45-7 500mg $243 2024-03-01 Buy
Biosynth Carbosynth FS100781 Senicapoc 289656-45-7 50mg $262.5 2021-12-16 Buy
Product number Packaging Price Buy
29679 100mg $57 Buy
29679 1g $426 Buy
29679 50mg $32 Buy
29679 500mg $243 Buy
FS100781 50mg $262.5 Buy

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Chemical Properties,Uses,Production

Description

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.

Uses

Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9702 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9339 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Finetech Industry Limited 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58
InvivoChem 		58

View Lastest Price from 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Senicapoc pictures 2021-07-13 Senicapoc
289656-45-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Senicapoc pictures 2021-07-10 Senicapoc
289656-45-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide pictures 2019-07-06 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
289656-45-7
 US $7.00 / kg 1kg 99% 100KG Career Henan Chemical Co
  • Senicapoc pictures
  • Senicapoc
    289656-45-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Senicapoc pictures
  • Senicapoc
    289656-45-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Spectrum

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide(289656-45-7)1HNMR

289656-45-7(2,2-bis(4-fluorophenyl)-2-phenyl-acetamide)Related Search:

2-FLUOROPHENYL CYCLOPENTYL KETONE 2,6-Difluorobenzamide 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl- 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide 4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide ICA 17043 Senicapoc ICA-17043;ICA 17043;ICA17043 Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl- Senicapoc (ICA17043) 289656-45-7 C20H15F2NO