ChemicalBook >> CAS DataBase List >>Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)-

Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)-

Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- structure

CAS No.: 2728780-74-1

Chemical Name:: Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)-

Synonyms: Nrf2 activator-6;Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)-

CBNumber:: CB312638672

Molecular Formula:: C31H37ClFN5O5

Molecular Weight:: 614.11

MDL Number:

MOL File:: 2728780-74-1.mol

Last updated:2025-04-17 18:22:24

Request For Quotation

Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- Properties

Boiling point	843.0±75.0 °C(Predicted)
Density	1.57±0.1 g/cm3(Predicted)
form	Solid
pka	4.65±0.40(Predicted)
color	White to off-white

Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- Chemical Properties,Uses,Production

Uses

Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4)[1].

References

[1] Cathy Louise LUCAS, et al. Tetrahydroisoquinoline compounds as nrf2 activators. WO2021214470A1.

Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- Suppliers

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