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ChemicalBook >> CAS DataBase List >>(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Structure
(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate structure
CAS No.
254881-77-1
Chemical Name:
(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
Synonyms
(4S)-4-Amino-1-Boc-D-proline methyl ester;(2R,4S)-N-Boc-4-amino-D-proline methyl ester;Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinecarboxylate;Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinedicarboxylate;Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected;1-tert-Butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate;(2r,4s)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate;(2R,4S)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl;Methyl (2R,4S)-1-(tert-butoxycarbonyl)-4-aMinopyrrolidine-2-carboxylate;1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicarboxylate
CBNumber:
CB31267586
Molecular Formula:
C11H20N2O4
Molecular Weight:
244.29
MDL Number:
MFCD08704545
MOL File:
254881-77-1.mol
Last updated:2025-07-24 18:13:47
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(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Properties

Boiling point 321 °C
Density 1.151
Flash point 148 °C
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 9.05±0.40(Predicted)
form solid
color Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2922498590

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR30679 1-tert-Butyl2-methyl(2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate 254881-77-1 250mg $106 2021-12-16 Buy
Biosynth Carbosynth FB153083 (2R,4S)-1-tert-Butyl 2-methyl4-aminopyrrolidine-1,2-dicarboxylate 254881-77-1 5mg $117 2021-12-16 Buy
SynQuest Laboratories 4H56-1-TG Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-Boc protected 254881-77-1 250mg $125 2021-12-16 Buy
Biosynth Carbosynth FB153083 (2R,4S)-1-tert-Butyl 2-methyl4-aminopyrrolidine-1,2-dicarboxylate 254881-77-1 10mg $203 2021-12-16 Buy
Biosynth Carbosynth FB153083 (2R,4S)-1-tert-Butyl 2-methyl4-aminopyrrolidine-1,2-dicarboxylate 254881-77-1 25mg $405 2021-12-16 Buy
Product number Packaging Price Buy
OR30679 250mg $106 Buy
FB153083 5mg $117 Buy
4H56-1-TG 250mg $125 Buy
FB153083 10mg $203 Buy
FB153083 25mg $405 Buy

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Chemical Properties,Uses,Production

Synthesis

1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-azido-1,2-pyrrolidinedicarboxylate

185304-04-5

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate

254881-77-1

(2R,4S)-1-tert-butyl 2-methyl-4-azido pyrrolidine-1,2-dicarboxylate (150 mg, 0.390 mmol) was used as a raw material, which was added to methanol (15 mL) together with Pd/C (150 mg, 0.390 mmol). The reaction system was replaced with hydrogen twice, followed by stirring the reaction for 15 h at room temperature. Upon completion of the reaction, the reaction mixture was concentrated to afford methyl (2R,4S)-1-Boc-4-amino-2-pyrrolidinecarboxylate as a gray oil (643 mg, 89% yield). The product was characterized by 1H NMR (600 MHz, CD3OD): δ 4.38-4.41 (m, 1H), 3.74-3.75 (m, 3H), 3.64-3.69 (m, 1H), 3.58-3.61 (m, 1H), 3.16-3.21 (m, 1H), 2.08-2.13 (m, 2H), 1.42- 1.48 (m, 9H); MS-ESI: m/z 145.20 [M+H-100]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00803
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 26, p. 4948 - 4963
[3] Tetrahedron, 1996, vol. 52, # 47, p. 15017 - 15030
[4] Journal of Organic Chemistry, 2018, vol. 83, # 8, p. 4491 - 4504

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-azido-1,2-pyrrolidinedicarboxylate Activated carbon Hydrogen Methanol Palladium

Preparation Products

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Suppliers

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49733 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10035 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
Supplier Advantage
AB PharmaTech,LLC 		55
Jinan Carbotang Biotech Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58

View Lastest Price from (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate pictures 2020-01-09 (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
254881-77-1
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Spectrum

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate(254881-77-1)1HNMR

254881-77-1((2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate)Related Search:

Acetonitrile 4-Dimethylaminobenzoic acid 4-Dimethylaminopyridine Betaine 4-Dimethylaminobenzaldehyde
Basic Violet 1 Glycine DIETHYL BIPHENYL-4,4'-DICARBOXYLATE Kresoxim-methyl Methanol
ALTRENOGEST Methyl acrylate Methyl acetate Paraquat dichloride Methylparaben
Methyl Methyl pyrrolidine-2-carboxylate hydrochloride BOC-D-PRO-OME

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(2R,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected 1-tert-Butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinedicarboxylate Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinecarboxylate (2R,4S)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl Methyl (2R,4S)-1-(tert-butoxycarbonyl)-4-aMinopyrrolidine-2-carboxylate Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected, trans-4-Amino-D-proline methyl ester, N1-BOC protected, (2R,4S)-4-amino-1-(tert-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidine (2R,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester (2r,4s)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate 1,2-Pyrrolidinedicarboxylic acid, 4-amino-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)- (4S)-4-Amino-1-Boc-D-proline methyl ester 1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicarboxylate (2R,4S)-N-Boc-4-amino-D-proline methyl ester 254881-77-1