isatidine
- CAS No.
- 15503-86-3
- Chemical Name:
- isatidine
- Synonyms
- isatidine;Retrorsin-N-oxid;RETRORSINE-N-OXIDE;12,18-Dihydroxysenecionane-11,16-dione 4-oxide;12,18-Dihydroxy-11,16-dioxosenecionane 4-oxide;[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, 12-oxide, (3Z,5R,6S,14aR,14bR)-
- CBNumber:
- CB31306005
- Molecular Formula:
- C18H25NO7
- Molecular Weight:
- 367.39
- MDL Number:
- MFCD00074872
- MOL File:
- 15503-86-3.mol
- MSDS File:
- SDS
| Melting point | 145°C |
|---|---|
| Boiling point | 497.95°C (rough estimate) |
| Density | 1.3204 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| pka | 11.96±0.40(Predicted) |
| FDA UNII | 51819GRV4U |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Isatidine (15503-86-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H373-H300 |
| Precautionary statements | P260-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 1544 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
isatidine price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL82630 | Retrorsine N-oxide phyproof? Reference Substance | 15503-86-3 | 10MG | $629 | 2024-03-01 | Buy |
| TRC | R279005 | RetrorsineN-Oxide | 15503-86-3 | 25mg | $1135 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 48572 | RetrorsineN-Oxide | 15503-86-3 | 25mg | $2200 | 2021-12-16 | Buy |
| Arctom | CFN00408 | Isatidine ≥98% | 15503-86-3 | 5mg | $468 | 2021-12-16 | Buy |
isatidine Chemical Properties,Uses,Production
Description
This hepatotoxic alkaloid occurs in certain Senecio species and was first isolated from S. isatideus D.C. It occurs abundantly in S. retrorsus D.C. and S. scleratus Schw. The alkaloid crystallizes in rhombic prisms as the dihydrate and has [α]27D . 8.25° (H 20). It is soluble in MeOH, hot EtOH and hot H20 but virtually insoluble in Et 20, Me2CO or CHCl 3. On reduction it absorbs 4 molecules of H2 to give hexahydrodeoxyisatidine which melts at l15-l20°C and then remelts at l83-4°C following an intermediate solidification. This compound gives a hydrochloride, m.p. 218°C (dec.); [α]20D - 52.5° (H20) and may be hydrolyzed with Ba(OHh to give a basic product, tetrahydroisatinecine, CSH1703N, m.p. l74.5°C; [α]20D - 88° (H 20). The alkaloid itself, on hydrolysis with Ba(OHh yields isatinecine and two acid products, isatinecic acid and the monolactone, the latter almost certainly being formed by the action of the base upon the acid.
Uses
Retrorsine N-oxide-D4 is a labelled analogue of Retrorsine N-oxide (R279005). Retrorsine N-oxide is a pyrrolizidine alkaloid that is naturally found in Senecio isatideus, a flowering plant that is native to the Netherlands. Retrorsine N-oxide is also known to raise blood pressure and can induce abnormal changes in the liver if ingested by animals or humans.
Definition
ChEBI: Isatidine is a citraconoyl group.
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also ESTERS.
References
Blackie., Pharrn. J., 138, 102 (1937) de Waal., Onderstepoort J., 12, 155 (1939) de Waal., Nature, 146, 777 (1940) de Waal., Pretorius., OnderstepoortJ., 17,181 (1941) Leisegang, Warren., J. Chern. Soc., 702 (1950)
isatidine Preparation Products And Raw materials
Raw materials
Preparation Products
isatidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 7059 | 55 |
| Biyu Biotechnology (Shanghai) Co., ltd | 021-26018599 | China | 270 | 56 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9287 | 58 |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4933 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55672 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 18108052721 | 2850505130@qq.com | China | 5182 | 58 |
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