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ALPHA-AMANITIN

ALPHA-AMANITIN structure

CAS No.: 23109-05-9

Chemical Name:: ALPHA-AMANITIN

Synonyms: α-Amanitin;A-AMANITIN;Aids004473;α-Amatoxin;Aids-004473;AMANITIN, A-;ALPHA-AMANTIN;ALPHA-AMANITIN;alpha-amatoxin;ALPHA-AMANTINE

CBNumber:: CB3142945

Molecular Formula:: C39H54N10O14S

Molecular Weight:: 918.98

MDL Number:: MFCD30207890

MOL File:: 23109-05-9.mol

MSDS File:: SDS

Last updated:2025-04-29 17:45:46

Product description	Number	Pack Size	Price
α-Amanitin from Amanita phalloides, ≥90% (HPLC), powder	A2263	1mg	$350
α-Amanitin ≥90%	17898	1mg	$227
alpha-Amanitin ≥95%(HPLC)	4025	1	$291
α-Amanitin	257178	1mg	$588
a-Amanitin	FA57619	5mg	$800

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ALPHA-AMANITIN Properties

Melting point	254-255 °C(lit.)
alpha	D20 +191°
Boiling point	1622.2±65.0 °C(Predicted)
Density	1.1626 (rough estimate)
refractive index	1.7400 (estimate)
storage temp.	−20°C
solubility	H₂O: 1.0 mg/mL
form	powder
pka	9.63±0.70(Predicted)
color	white to light yellow
biological source	Amanita phalloides
optical activity	+19120 (H2O)
Water Solubility	Soluble to 5 mM in ethanol and to 5 mM in water
ε(extinction coefficient)	13,500 at 310nm in H2O at 1M
Merck	13,370
BRN	1071138
InChIKey	CIORWBWIBBPXCG-PWKRRBCNNA-N
EWG's Food Scores	1
FDA UNII	E04K0QZ999
UNSPSC Code	12352202
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H300-H373

Precautionary statements

P260-P264-P270-P301+P310-P314-P405

Hazard Codes

T+

Risk Statements

26/27/28-33-26/28

Safety Statements

36/37/39-45-36/37-28

RIDADR

UN 3462 6.1/PG 2

WGK Germany

RTECS

BD6195000

8-10-18-21

HazardClass

6.1(a)

PackingGroup

HS Code

2934999090

Hazardous Substances Data

23109-05-9(Hazardous Substances Data)

Toxicity

LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland)

NFPA 704

	0
4		0

ALPHA-AMANITIN price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A2263	α-Amanitin from Amanita phalloides, ≥90% (HPLC), powder	23109-05-9	1mg	$350	2025-07-31	Buy
Cayman Chemical	17898	α-Amanitin ≥90%	23109-05-9	1mg	$227	2024-03-01	Buy
Tocris	4025	alpha-Amanitin ≥95%(HPLC)	23109-05-9	1	$291	2021-12-16	Buy
Usbiological	257178	α-Amanitin	23109-05-9	1mg	$588	2021-12-16	Buy
Biosynth Carbosynth	FA57619	a-Amanitin	23109-05-9	5mg	$800	2021-12-16	Buy

Product number	Packaging	Price	Buy
A2263	1mg	$350	Buy
17898	1mg	$227	Buy
4025	1	$291	Buy
257178	1mg	$588	Buy
FA57619	5mg	$800	Buy

ALPHA-AMANITIN Chemical Properties,Uses,Production

Uses

α-Amanitin has been used:

for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
to induce nephrotoxicity in mice renal tissues
to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay

Biological Activity

α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.

Biochem/physiol Actions

The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

in vivo

The intravenous LD₅₀ dose of alpha-Amanitin is 0.327 mg/kg body weight after intravenous injection into BALB/c mice. After 12 h of alpha-Amanitin injection in caudal vein, the levels of WBC, RBC and HGB decrease significantly, while those of BUN and Crea increase significantly in serum. alpha-Amanitin inhibits some genes (Hsp90b1, Irx4, etc.), whose encoded proteins regulate the RNA polymerase II activity. alpha-Amanitin down-regulates some proteins (Nmi, Trpc5, etc.) taking part in the transcription progress^[1]. alpha-Amanitin has potent activity in DTC suppression. Mice injected with alpha-Amanitin (0.4 mg/kg, i.p.)-treated cells maintain their body weight, while those receiving a peritoneal injection of MKN45 cells show a constant decrease in body weight^[2].

IC 50

Traditional Cytotoxic Agents

storage

Store at -20°C

ALPHA-AMANITIN Preparation Products And Raw materials

Raw materials

Preparation Products

ALPHA-AMANITIN Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Hebei Kangcang new material Technology Co., LTD	+8615713292910	Nancy@kangcang.com.cn	China	341	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	964	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3387	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	787	58
Hebei baicao biology science and technology co., ltd	+86-19131911055 +8617824879454	zhang@hbbocao.com	China	1029	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58

Supplier	Advantage
Aladdin Scientific	58
Hebei Kangcang new material Technology Co., LTD	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Hebei shuoxi biotechnology co. LTD	58
RongNa Biotechnology Co.,Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
ChemExpress	58
Hebei baicao biology science and technology co., ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from ALPHA-AMANITIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-15	ALPHA-AMANITIN 23109-05-9			0.99		RongNa Biotechnology Co.,Ltd
2024-05-11	alpha-Amanitin 23109-05-9	US $9.00-70.00 / g	10g	99%	10 tons	Hebei Kangcang new material Technology Co., LTD
2024-01-08	α-Amanitin 23109-05-9	US $60.00-45.00 / mg	1mg	99.96%	1kg	Wuhan Boyuan Import & Export Co., LTD

ALPHA-AMANITIN
23109-05-9
0.99
RongNa Biotechnology Co.,Ltd

alpha-Amanitin
23109-05-9
US $9.00-70.00 / g
99%
Hebei Kangcang new material Technology Co., LTD

α-Amanitin
23109-05-9
US $60.00-45.00 / mg
99.96%
Wuhan Boyuan Import & Export Co., LTD

23109-05-9(ALPHA-AMANITIN)Related Search:

gamma-amanitin ALPHA-AMANITIN OLEATE alpha-Amanitin, 1-l-aspartic acid- METHYL ALPHA-AMANITIN OLEATE 6'-O-methyl alpha-amanitin

4,9-dioxo-5,10-diazatetradecane ALPHA-AMANITIN

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Aids004473 Aids-004473 AMANITIN, a-(RG) AMANITIN, a-(RG)(CALL) cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide alpha-AMantine, froM AManita Phalloides AMANITIN, A- ALPHA-AMANITIN ALPHA-AMANITIN, AMANITA SPECIES ALPHA-AMANITINE Cyclo[L-Asn-L-t4Hyp-[(3R,4R)-4,5-dihydroxy-3-methyl-L-Nva-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-] alpha-amatoxin cyclic(l-asparaginyl-4-hydroxy-l-prolyl-(r)-4,5-dihydroxy-l-isoleucyl-6-hydrox ulfide,(r)-s-oxide y-2-mercapto-l-tryptophylglycyl-l-isoleucylglycyl-l-cysteinyl),cyclic(4-8)-s ALPHA-AMANITIN FROM AMANITA PHALLOIDES A-AMANITIN FROM AMANITA PHALLOIDES ALPHA-AMANTIN ALPHA-AMANTINE A-AMANTINE, FROM AMANITA PHALLOIDES alpha-Amanitine, from Amanita Phalloides Α-AMANITIN;Α-AMATOXIN alpha-Amanitin (α-Amanitin α-Amanitin DISCONTINUED α-Amanitin, from Amanita Phalloides A-AMANITIN α-Amanitin α-Amatoxin *Chlorobutanol Impurity?1 (Chlorobutanol EP Impurity?A)(Chloroform) 23109-05-9 C39H54N10O14S BioChemical Biochemicals and Reagents Cell Biology Cell Signaling and Neuroscience Gene Regulation and Expression Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Type Enzyme Inhibitors DNA-RNA Transcription Regulators Other Alkaloids DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience Gene Regulation and Expression Cell Signaling and Neuroscience Mushroom Toxins and Venoms Enzyme Inhibitors Enzyme Inhibitors by Type Other Miscellaneous Enzyme inhibitor