Orantinib (SU6668)
- CAS No.
- 252916-29-3
- Chemical Name:
- Orantinib (SU6668)
- Synonyms
- TSU-68;Orantinib;NSC 702827;TSU-68, >=99%;TSU-68 (SU6668);SU 6668(TSU-68);Orantinib (SU6668;Orantinib (TSU-68);TSU-68 (Orantinib,SU6668);TSU-68 (SU6668, Orantinib)
- CBNumber:
- CB31456201
- Molecular Formula:
- C18H18N2O3
- Molecular Weight:
- 310.35
- MDL Number:
- MFCD03426212
- MOL File:
- 252916-29-3.mol
| Melting point | 252-254 °C |
|---|---|
| Boiling point | 590.5±50.0 °C(Predicted) |
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4?+-.0.10(Predicted) |
| color | Orange to Brown |
| NCI Dictionary of Cancer Terms | orantinib |
| FDA UNII | 9RL37ZZ665 |
| NCI Drug Dictionary | orantinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318-H361-H372 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P280-P301+P310-P321-P330-P305+P351+P338-P308+P313-P314-P405-P501 | |||||||||
| NFPA 704 |
|
Orantinib (SU6668) price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13873 | SU 6668 ≥98% | 252916-29-3 | 1mg | $31 | 2024-03-01 | Buy |
| Cayman Chemical | 13873 | SU 6668 ≥98% | 252916-29-3 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 13873 | SU 6668 ≥98% | 252916-29-3 | 10mg | $121 | 2024-03-01 | Buy |
| Usbiological | 022488 | TSU-68 | 252916-29-3 | 10mg | $396 | 2021-12-16 | Buy |
| TRC | T797550 | TSU-68 | 252916-29-3 | 50mg | $425 | 2021-12-16 | Buy |
Orantinib (SU6668) Chemical Properties,Uses,Production
Uses
TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 towards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses.
Uses
3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively.
Uses
TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 t owards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses.
Definition
3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 2-(2-carboxyethyl)-3,5-dimethylpyrrol-3-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth facto receptor 1.
Biological Activity
ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC 50 values are 0.06, 2.43, 3.04 and > 100 μ M at PDGFR β , VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC 50 values are 0.41, 9.3 and 16.5 μ M for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo . Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.
in vitro
biochemical kinetic studies using isolated flk-1, fgf receptor 1, and pdgf receptor β kinases revealed that tsu-68 has competitive inhibitory properties with respect to atp. in cellular systems, tsu-68 inhibited receptor tyrosine phosphorylation and mitogenesis after stimulation of cells by appropriate ligands [1].
in vivo
oral or i.p. administration of tsu-68 in athymic mice resulted in significant growth inhibition of a diverse panel of human tumor xenografts of glioma, melanoma, lung, colon, ovarian, and epidermoid origin [1].
storage
Store at RT
References
[1] laird ad, vajkoczy p, shawver lk et al. su6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. cancer res. 2000 aug 1;60(15):4152-60.
[2] okamoto i, yoshioka h, takeda k et al. phase i clinical study of the angiogenesis inhibitor tsu-68 combined with carboplatin and paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer. j thorac oncol. 2012 feb;7(2):427-33.
Orantinib (SU6668) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Hebei Lihe Biotechnology Co.,ltd | 86-311-80292533 13315122300 | sales@lihebiotech.com | CHINA | 305 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
View Lastest Price from Orantinib (SU6668) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid pictures](https://img.chemicalbook.com/ProductImageEN/2018-8/Small/c1d1bdc1-347d-409a-920f-da93f9c5b3bd.gif) |
2019-07-06 | 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
252916-29-3
|
US $1.00 / KG | 1G | 99% | 100KG | Career Henan Chemical Co |
-
- 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
252916-29-3
- US $1.00 / KG
- 99%
- Career Henan Chemical Co