ChemicalBook >> CAS DataBase List >>alpha,alpha-Diphenyl-4-piperidinomethanol
alpha,alpha-Diphenyl-4-piperidinomethanol
- CAS No.
- 115-46-8
- Chemical Name:
- alpha,alpha-Diphenyl-4-piperidinomethanol
- Synonyms
- AZACYCLONOL;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL;Azacyclanol;alpha,alpha-diphenyl-4-piperidinemethano;mer17;MER 17;Frenquel;Frenoton;Calmeran;MDL 4829
- CBNumber:
- CB3146211
- Molecular Formula:
- C18H21NO
- Molecular Weight:
- 267.37
- MDL Number:
- MFCD00066980
- MOL File:
- 115-46-8.mol
- MSDS File:
- SDS
Last updated:2024-04-08 13:55:39
| Melting point | 160-163 °C |
|---|---|
| Boiling point | 410.55°C (rough estimate) |
| Density | 1.0449 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5100 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | Chloroform, Methanol (Slightly, Sonicated) |
| pka | 13.32±0.29(Predicted) |
| form | Solid |
| color | White to light beige |
| InChIKey | ZMISODWVFHHWNR-UHFFFAOYSA-N |
| CAS DataBase Reference | 115-46-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2MMR990PEM |
| NIST Chemistry Reference | Azacyclonol(115-46-8) |
alpha,alpha-Diphenyl-4-piperidinomethanol price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.14973 | Diphenyl-4-piperidinemethanol for synthesis | 115-46-8 | 25g | $121 | 2024-03-01 | Buy |
| TCI Chemical | P1369 | α-(4-Piperidyl)benzhydrol >99.0%(GC)(T) | 115-46-8 | 5g | $39 | 2024-03-01 | Buy |
| TCI Chemical | P1369 | α-(4-Piperidyl)benzhydrol >99.0%(GC)(T) | 115-46-8 | 25g | $123 | 2024-03-01 | Buy |
| Alfa Aesar | H61281 | Diphenyl(4-piperidinyl)methanol, 95% | 115-46-8 | 25g | $70.9 | 2021-12-16 | Buy |
| Alfa Aesar | H61281 | Diphenyl(4-piperidinyl)methanol, 95% | 115-46-8 | 100g | $219 | 2021-12-16 | Buy |
alpha,alpha-Diphenyl-4-piperidinomethanol Chemical Properties,Uses,Production
Description
alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.
Chemical Properties
α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.
Originator
Frenquel,Merrell,US,1955
Uses
α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.
Uses
Anxiolytic;H1 antagonist
Definition
ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment
with ammonia and when so obtained has a melting point of 160-161°C.
brand name
Frenquel (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
alpha,alpha-Diphenyl-4-piperidinomethanol Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 433)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9350 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from alpha,alpha-Diphenyl-4-piperidinomethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-12-14 | alpha,alpha-Diphenyl-4-piperidinomethanol
115-46-8
|
US $26.00 / g | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2021-07-23 | alpha,alpha-Diphenyl-4-piperidinomethanol USP/EP/BP
115-46-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-13 | alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- alpha,alpha-Diphenyl-4-piperidinomethanol
115-46-8
- US $26.00 / g
- 99%
- Qiuxian Baitai New Material Co., LTD
-
- alpha,alpha-Diphenyl-4-piperidinomethanol USP/EP/BP
115-46-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
115-46-8(alpha,alpha-Diphenyl-4-piperidinomethanol)Related Search:
TIMTEC-BB SBB003057
4-Piperidinemethanol, alpha,alpha-diphenyl-
Ataractan
Azacyklonol
Calmeran
Diphenyl(4-piperidinyl)methanol
Diphenyl-4-piperidylmethanol
Frenoton
Frenquel
MER 17
mer17
Azacyclonol (base and/or unspecified salts)
AZACYCLONOL (ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL)
4-[Hydroxy(diphenyl)methyl]piperidine
Diphenyl(piperidin-4-yl)methanol, Azacyclonol, alpha-(Piperidin-4-yl)benzhydrol
α-(4-Piperidyl)benzhydrol
alpha,alpha-Diphenyl-4-piperidinoMethanol, 98+% 5GR
4-(DiphenylhydroxyMethyl)piperidine
MDL 4829
DIPHENYL-4-PIPERIDINEMETHANOL FOR SYNTHE
a-(4-Piperidyl)benzhydrol
Psychosa
α,α-Diphenyl-4-piperidinomethanol
a, a- Azacyclonol
4-PiperidineMethanol, a,a-diphenyl-
phenyl(4-(piperidin-1-yl)phenyl)methanol
ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE METHONOL
Diphenyl-4-piperidinemethanol for synthesis
α, α-Diphenyl-4-piperidinomethanol, 98+%
Psychosan
Azacyclonol Base
AzacyclonolBase98%
ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL
ALPHA-(4-PIPERIDYL)BENZHYDROL
A,A-DIPHENYL-4-PIPERIDINEMETHANOL
4-(ALPHA,ALPHA DIPHENYL) PIPERIDINE METHANOL
2,2-DIPHENYL-4-PIPERIDONOMETHANOL
AZACYCLONAL
DIPHENYL-4-PIPERIDINEMETHANOL
DIPHENYL-PIPERIDIN-4-YL-METHANOL
gamma-pipradol
α,α-Diphenyl-4-piperidinylcarbinol
alpha,alpha-Diphenyl-4-piperidinomethanol, 98+%
alpha,alpha-Diphenyl-4-piperid
AZACYCLONOL A , A -DIPHENYL-4-PIPERIDINEMETHANOL
Fexofenadine hydrochloride impurity E (EP)
Fexofenadine EP Impurity E
Terfenadine Impurity 1
Fexofenadine Related Compound E
ALPHA ALPHA -DIPHENYL-4-PIPERDINEMETHANO L
Fexofenadine Impurity 5（Fexofenadine EP Impurity E）
ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE
α-(4-Piperidyl)benzhydrol>
Diphenyl(piperidin-4-yl)methanol (A
4-Piperidinemethanol, α,α-diphenyl-
γ-pipradol
α,α-diphenyl-4-piperidinemethanol
ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL