-dimethoxyphenylamide
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide
- CAS No.
- 944261-79-4
- Chemical Name:
- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide
- Synonyms
- brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
- CBNumber:
- CB31471262
- Molecular Formula:
- C19H16ClNO4
- Molecular Weight:
- 357.79
- MDL Number:
- MFCD10574689
- MOL File:
- 944261-79-4.mol
- MSDS File:
- SDS
| Melting point | 128-130?C |
|---|---|
| Boiling point | 450.6±45.0 °C(Predicted) |
| Density | 1.294±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >10mg/mL |
| pka | 11.72±0.70(Predicted) |
| form | powder |
| color | white to tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| FDA UNII | 339LBH1395 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide price
More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A3109 | A-803467 ≥98% (HPLC) | 944261-79-4 | 10mg | $174 | 2024-03-01 | Buy |
| Sigma-Aldrich | A3109 | A-803467 ≥98% (HPLC) | 944261-79-4 | 50mg | $279.6 | 2024-03-01 | Buy |
| Alfa Aesar | J67281 | A-803467, 98% | 944261-79-4 | 5mg | $78.2 | 2023-06-20 | Buy |
| Alfa Aesar | J67281 | A-803467, 98% | 944261-79-4 | 10mg | $120 | 2021-12-16 | Buy |
| Cayman Chemical | 10012588 | A-803467 ≥98% | 944261-79-4 | 5mg | $37 | 2024-03-01 | Buy |
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Chemical Properties,Uses,Production
Description
Nav1.8 is a tetrodotoxin-
Chemical Properties
White Solid
Uses
A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain. Analgesic.
General Description
The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.
Biological Activity
Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.
Biochem/physiol Actions
A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.
storage
+4°C
References
1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide
944261-79-4
|
US $1.00 / KG | 1KG | 95%~99% | per week:100kg | Career Henan Chemical Co |
-
- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide
944261-79-4
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co
944261-79-4(5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide)Related Search:
-dimethoxyphenylamide 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide A 803467 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)- 5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide 2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 A-803467, >=99% A803467;A 803467 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt brgt -dimethoxyphenylamide A-803467, >98% CS-374 [3H]-A-803467 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP 944261-79-4 Ion Channels Inhibitors Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sodium channel