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Methocarbamol

Methocarbamol
Methocarbamol structure
CAS No.
532-03-6
Chemical Name:
Methocarbamol
Synonyms
ahr85;Relax;AHR 85;Avetil;Miowas;Delaxin;Perilax;Robamol;Robaxan;Robaxin
CBNumber:
CB3148129
Molecular Formula:
C11H15NO5
Formula Weight:
241.24
MOL File:
532-03-6.mol

Methocarbamol Properties

Melting point:
95-97°C
Boiling point:
384.01°C (rough estimate)
Density 
1.2611 (rough estimate)
refractive index 
1.5080 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
neat
pka
13.08±0.20(Predicted)
Merck 
14,5980
CAS DataBase Reference
532-03-6(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
125OD7737X
NIST Chemistry Reference
Methocarbamol(532-03-6)
EPA Substance Registry System
Methocarbamol (532-03-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H317-H334
Precautionary statements  P261-P280-P284-P304+P340-P333+P313-P342+P311-P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-42/43
Safety Statements  36
WGK Germany  3
RTECS  TY8750000
HS Code  29222990

Methocarbamol price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G7012 Guaiacol glyceryl ether carbamate analytical standard 532-03-6 5g $30.7 2021-03-22 Buy
Sigma-Aldrich 1412008 Methocarbamol United States Pharmacopeia (USP) Reference Standard 532-03-6 200mg $366 2021-03-22 Buy
TCI Chemical M2254 Methocarbamol >98.0%(HPLC)(N) 532-03-6 5g $27 2021-03-22 Buy
TCI Chemical M2254 Methocarbamol >98.0%(HPLC)(N) 532-03-6 25g $80 2021-03-22 Buy
Cayman Chemical 23870 Methocarbamol ≥98% 532-03-6 5g $26 2021-03-22 Buy

Methocarbamol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Robaxin ,Robins,US,1957

Uses

A muscle relaxant (skeletal).

Uses

For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.

Uses

Methocarbamol suppresses multisynaptic pathways in the spinal cord. It is used for relieving spasms and skeletal muscle pain as well as for treating tetanus. Synonyms of this drug are delaxin, forbaxin, robamol, robaxin, and tresortil.

Manufacturing Process

The starting material for methocarbamol is 3-o-methoxyphenoxy-1,2- propanediol (guaiacol glyceryl ether) (see entry under Guaifenesin for its preparation). To a stirred suspension of 198.2 g (1.0 mol) of 3-omethoxyphenoxy-1,2-propanediol in 1,000 ml of dry benzene contained in a 5-liter, 3-neck, round bottom flask equipped with a thermometer, dropping funnel and blade stirrer, was added dropwise (in 30 minutes) a solution of 98.9 g (1.0 mol) of phosgene in 400 ml of cold dry benzene. The mixture was stirred at 30°C until all solid material dissolved (about 3 hours was required) and stirring was continued for 30 minutes longer. To this mixture was added dropwise 79.1 g (1.0 mol) of dry pyridine, the temperature being held below 30°C by cooling. After addition of the pyridine, stirring at 30°C was continued for 30 minutes.
The mixture was cooled to 7°C, extracted with two 500-cc portions of ice water to remove pyridine hydrochloride, and the benzene solution of 3-omethoxyphenoxy-2-hydroxypropyl chlorocarbonate was added to 500 ml of cold concentrated ammonium hydroxide. The mixture was vigorously stirred at 5°C for 6 hours, then the crude white precipitate of 3-o-methoxyphenoxy-2- hydroxypropyl carbamate was filtered off, dissolved in 1,500 ml of hot benzene and completely dried by codistillation of last traces of water with benzene, treated with decolorizing carbon and filtered while hot. On cooling 160 g of product crystallized as white needles melting at 88° to 90°C.

brand name

Delaxin (Ferndale); Forbaxin (Forest); Robaxin (Baxter Healthcare).

Therapeutic Function

Muscle relaxant

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 1595, 1957 DOI: 10.1021/jo01363a016

General Description

Methocarbamol, 3-(o-methoxyphenoxy)-1,2-propanediol 1-carbamate (Robaxin), issaid to be more sustained in effect than mephenesin. Likelysites for metabolic attack include the secondary hydroxylgroup and the two ring positions opposite the ether functions.The dihydric parent compound, guaifenesin, is used asan expectorant.

Chemical Synthesis

Methocarbamol, 3-(2-methoxyphenoxy)-1,2-propanediol-1 carbamate (15.3.13), is synthesized by successive reaction with phosgene and then ammonia into 3- (2-methoxyphenoxy)propanediol-1,2.

Veterinary Drugs and Treatments

In dogs and cats, methocarbamol is indicated (FDA approved) “as adjunctive therapy of acute inflammatory and traumatic conditions of the skeletal muscle and to reduce muscular spasms.” In horses, intravenous use is indicated (FDA approved) “as adjunctive therapy of acute inflammatory and traumatic conditions of the skeletal muscle to reduce muscular spasms, and effect striated muscle relaxation.” (Package insert; Robaxin?V—Robins)

Methocarbamol Preparation Products And Raw materials

Raw materials

Preparation Products


Methocarbamol Suppliers

Global( 232)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
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Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
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Shenzhen Nexconn Pharmatechs Ltd
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Hubei Jusheng Technology Co.,Ltd.
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027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
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Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58
BOC Sciences
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Chongqing Chemdad Co., Ltd
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View Lastest Price from Methocarbamol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Methocarbamol
532-03-6
US $0.00-0.00 / Kg/Drum 1KG 98.5%-101.5%; USP 500KG WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-26 Methocarbamol
532-03-6
US $10.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-07-20 Methocarbamol
532-03-6
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

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