Clinafloxacin hydrochloride
- CAS No.
- 105956-99-8
- Chemical Name:
- Clinafloxacin hydrochloride
- Synonyms
- M 1091;KR 11095;ClinafoxacinHCl;CLINAFLOXACIN HCL;Clinafloxacinhydrochloride;CLINANFLOXACIN HYDROCHLORIDE;HYDROGEN CLINAFLOXACIN CHLORIDE;Clinafloxacin hydrochloride USP/EP/BP;Clinafloxacin hydrochloride (PD127391);7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride
- CBNumber:
- CB3148235
- Molecular Formula:
- C17H18Cl2FN3O3
- Molecular Weight:
- 402.25
- MDL Number:
- MFCD03840545
- MOL File:
- 105956-99-8.mol
- MSDS File:
- SDS
| Melting point | 162-168°C |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated) |
| form | Solid |
| color | Pale Yellow to Light Yellow |
| Stability | Hygroscopic |
| FDA UNII | G17M59V0FY |
Clinafloxacin hydrochloride price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16923 | Clinafloxacin (hydrochloride) ≥95% | 105956-99-8 | 100mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 16923 | Clinafloxacin (hydrochloride) ≥95% | 105956-99-8 | 1g | $456 | 2024-03-01 | Buy |
| Cayman Chemical | 16923 | Clinafloxacin (hydrochloride) ≥95% | 105956-99-8 | 250mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 16923 | Clinafloxacin (hydrochloride) ≥95% | 105956-99-8 | 500mg | $292 | 2024-03-01 | Buy |
| TRC | C579000 | ClinafloxacinHydrochloride | 105956-99-8 | 500mg | $340 | 2021-12-16 | Buy |
Clinafloxacin hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
antibacterial
Uses
A new fluoroquinolone antimicrobial agent as a potent intraphagocytic bactericidal agent for both gram-positive and gram-negative bacteria.
Biological Activity
clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both dna gyrase and topoisomerase iv dually in streptococcus pneumonia. clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.in selected volunteer subjects and patients, after the administration of oral and intravenous doses of racemic drug, the clinafloxacin showed a broad-spectrum antibiotic of the quinolone carboxylic acid category. the absorption of the clinafloxacin enantiomer was rapid after oral 400 mg dose and 400 mg intravenous dose of racemic drug [1]. clinafloxacin showed high activity against s. pneumoniae 7785 with the mic value of 0.125 μg/ml. clinafloxacin showed potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens [2]. clinafloxacin has been identified as the most active fluoroquinolone against s. pneumoniae compared to grepafloxacin, levofloxacin, ofloxacin, sparfloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].
References
[1]. humphrey g h, shapiro m a, randinitis e j, et al. pharmacokinetics of clinafloxacin enantiomers in humans[j]. the journal of clinical pharmacology, 1999, 39(11): 1143-1150.
[2]. pan x s, fisher l m. dna gyrase and topoisomerase iv are dual targets of clinafloxacin action in streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 1998, 42(11): 2810-2816.
[3]. jorgensen j h, weigel l m, swenson j m, et al. activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 2000, 44(11): 2962-2968.
Clinafloxacin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 13854 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | sales@zhiwe.net | China | 587 | 61 |
| Supplier | Advantage |
|---|---|
| career henan chemical co | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| WinWin Chemical CO., Limited | 58 |
| Dideu Industries Group Limited | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| ZHIWE CHEMTECH CO LTD | 61 |
View Lastest Price from Clinafloxacin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Clinafloxacin hydrochloride USP/EP/BP
105956-99-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | Clinafloxacin hydrochloride
105956-99-8
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Clinafloxacin hydrochloride USP/EP/BP
105956-99-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Clinafloxacin hydrochloride
105956-99-8
- US $1.00 / KG
- 98%
- Career Henan Chemical Co