Elesclomol
- CAS No.
- 488832-69-5
- Chemical Name:
- Elesclomol
- Synonyms
- CS-482;STA-4783;elesclomol;STA-4783;STA4783;Elesclomol USP/EP/BP;ElescloMol (STA-4783);Enzastaurin Impurity 6;N1',N3'-dimethyl-N1',N3'-di(phenylcarbonothioyl)malonohydrazide;N'1,N'3-Dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide;1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid
- CBNumber:
- CB31518510
- Molecular Formula:
- C19H20N4O2S2
- Molecular Weight:
- 400.52
- MDL Number:
- MFCD12911784
- MOL File:
- 488832-69-5.mol
- MSDS File:
- SDS
| Density | 1.313 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥20.15 mg/mL in DMSO; ≥5.68 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 7.99±0.70(Predicted) |
| FDA UNII | 6UK191M53P |
| NCI Drug Dictionary | elesclomol |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Elesclomol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2651 | Elesclomol ≥98% (HPLC) | 488832-69-5 | 5MG | $97.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2651 | Elesclomol ≥98% (HPLC) | 488832-69-5 | 25MG | $395 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0005195 | ELESCLOMOL 95.00% | 488832-69-5 | 1MG | $603.95 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180784 | Elesclomol (STA-4783) >98% | 488832-69-5 | 100mg | $690.2 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FE157996 | Elesclomol | 488832-69-5 | 50mg | $270 | 2021-12-16 | Buy |
Elesclomol Chemical Properties,Uses,Production
Definition
ChEBI: A carbohydrazide obtained by formal condensation of the carboxy groups of malonic acid with the hydrino groups of two molar equivalents of N-methylbenzenecarbothiohydrazide
Biological Activity
elesclomol (also known as sta-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ros) and the induction of unmanageable levels of oxidative stress. elesclomol exhibits autitumor activity against a broad spectrum of types of cancer cell in human tumor xengograft models due to its excessive ros production and elevated levels of oxidative stress leading to the death of cancer cells. elesclomol is currently being studies as a novel cancer therapeutic, in which it has demonstrated ability to prolong progression-free survival in study subjects.ronald k. blackman, kahlin cheung-ong, marinella gebbia, david a. proia, suqin he, jane kepros, aurelie jonneaux, philippe marchetti, jerome kluza, patricia e. rao, yumiko wada, guri giaever, corey nislow. mitochondrial electron transport is the cellular target of the oncology drug elesclomol. plos one 2012; 7(1): e29798jessica r. kirshner, suqin he, vishwasenani balasubramanyam, jane kepros, chin-yu yang, mei zhang, zhenjian du, james barsoum, and john bertin. elesclomol induces cancer cell apoptosis through oxidative stress. mol cancer ther 2008; 7:2319-2327
target
HSP70
Elesclomol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
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