BI 2536
- CAS No.
- 755038-02-9
- Chemical Name:
- BI 2536
- Synonyms
- BI 2536;CS-1984;BI-2536(R-);(R)-BI-2536;BI 2536, >=98%;BI2536/BI-2536;BI 2536 USP/EP/BP;BI 2536;BI-2536; BI2536;Boehringer PLK-1 inhibitor;BI-2536, BoehringerPLK-1 inhibitor
- CBNumber:
- CB31562104
- Molecular Formula:
- C28H39N7O3
- Molecular Weight:
- 521.65
- MDL Number:
- MFCD10565924
- MOL File:
- 755038-02-9.mol
- MSDS File:
- SDS
| Density | 1.28 |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml) |
| form | Yellow powder. |
| pka | 14.09±0.20(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| NCI Dictionary of Cancer Terms | BI 2536 |
| FDA UNII | 4LJG22T9C6 |
| NCI Drug Dictionary | BI 2536 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
BI 2536 price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17385 | BI 2536 ≥95% | 755038-02-9 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17385 | BI 2536 ≥95% | 755038-02-9 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 17385 | BI 2536 ≥95% | 755038-02-9 | 10mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 17385 | BI 2536 ≥95% | 755038-02-9 | 50mg | $758 | 2024-03-01 | Buy |
| TRC | B373470 | BI2536 | 755038-02-9 | 5mg | $105 | 2021-12-16 | Buy |
BI 2536 Chemical Properties,Uses,Production
Description
BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1?and selective2?Polo-like kinase inhibitor?that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1?It was later found to be a potent inhibitor (IC50?= 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3?BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4
Uses
BI 2536 is a PLK1 inhibitor, inducing apoptosis together with micro-tubule-destabilizing drugs in preclinical rhabdomyosarcoma models. Anti-cancer and potent PLK1 inhibitor.
target
Plk1
References
1) Steegmaier?et al.?(2007),?BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo; Curr. Biol.,?17?316 2) Davis?et al.?(2011),?Comprehensive analysis of kinase inhibitor selectivity; Nat. Biotechnol.,?29?1046 3) Ciceri?et al.?(2014),?Dual kinase-bromodomain inhibitors for rationally designed polypharmacology; Nat. Chem. Biol.,?10?305 4) Xiao?et al.?(2016),?Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival; Mol. Cell,?64?493
BI 2536 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |