PROPERICYAZINE
- CAS No.
- 2622-26-6
- Chemical Name:
- PROPERICYAZINE
- Synonyms
- ic6002;rp8908;wh7508;6909rp;Aolept;IC 6002;RP 8908;RP 8909;WH 7508;6909 RP
- CBNumber:
- CB3162774
- Molecular Formula:
- C21H23N3OS
- Molecular Weight:
- 365.49
- MDL Number:
- MFCD00210348
- MOL File:
- 2622-26-6.mol
| Melting point | 116-117° |
|---|---|
| Boiling point | 593.4±50.0 °C(Predicted) |
| Density | 1.1198 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.87±0.20(Predicted) |
| color | Light Yellow to Yellow |
| Water Solubility | 38.01mg/L(37 ºC) |
| CAS DataBase Reference | 2622-26-6 |
| FDA UNII | 3405M6FD73 |
| ATC code | N05AC01 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RTECS | SN7175000 | |||||||||
| Toxicity | LD50 orally in rats: 395 mg/kg (Schafer) | |||||||||
| NFPA 704 |
|
PROPERICYAZINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P287360 | Pericyazine | 2622-26-6 | 25mg | $185 | 2021-12-16 | Buy |
| TRC | P287360 | Pericyazine | 2622-26-6 | 250mg | $1455 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003549 | PROPERICYAZINE 95.00% | 2622-26-6 | 2G | $2035 | 2021-12-16 | Buy |
| ChemScene | CS-0002963 | Pericyazine 99.83% | 2622-26-6 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-0002963 | Pericyazine 99.83% | 2622-26-6 | 10mg | $150 | 2021-12-16 | Buy |
PROPERICYAZINE Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Originator
Aolept, Bayer Vital
Uses
Psychotherapeutic phenothiazine. Antipsychotic.
Uses
Spectrophotometric reagent for palladium and ruthenium.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.
Manufacturing Process
2-Cyano-10-(3-methanesulfonyloxypropyl)phenthiazine and 4hydroxypiperidine in toluene were heated under reflux with stirring. The reaction mixture was allowed to cool and water was added. The resulting toluene solution layer was decanted and washed twice with water. The toluene solution was then stirred with 5% hydrochloric acid. The hydrochloride of the desired phenthiazine base precipitated in gummy condition in the aqueous layer. This was decanted and treated with sodium hydroxide (density 1.33). It was then extracted three times with ethyl acetate. The extracts were dried over sodium sulfate, filtered and concentrated in vacuum. A resinous product was obtained. This product was dissolved in a mixture of benzene and cyclohexane and chromatographed on a column containing alumina. The chromatographed product was eluted successively with mixtures of benzene and cyclohexane and then with benzene and finally with a mixture of benzene and ethyl acetate. The eluates were evaporated to yield a crude product. This product was recrystallised from aqueous ethanol (40% water) and yielded 2cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenthiazine as white crystals.
Therapeutic Function
Neuroleptic
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN-, NOx, and SOx. See also NITRILES.
Purification Methods
It recrystallises from a saturated solution in cyclohexane. It is antipsychotic and is a sensitive reagent for Pd, Va, Ru, Rh and Au. [Gowda et al. Anal Chem 55 1816 1983, Anal Chim Acta 154 347 1983, Beilstein 27 III/IV 4110.]
PROPERICYAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9571 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9309 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |