Enalaprilat
- CAS No.
- 76420-72-9
- Chemical Name:
- Enalaprilat
- Synonyms
- Vasotec IV;Enalaprilat;MK 421 diacid;Enalapril acid;Enalapril diacid;Enalaprilic Acid;ENALAPRILAT HYDRATE;Enalaprilat USP/EP/BP;enalaprilat (anhydrous);Enalapril maleate impurity C
- CBNumber:
- CB3163049
- Molecular Formula:
- C18H24N2O5
- Molecular Weight:
- 348.39
- MDL Number:
- MFCD00865786
- MOL File:
- 76420-72-9.mol
- MSDS File:
- SDS
| Melting point | 148-151°C |
|---|---|
| alpha | D -67.0° (0.1M HCl) |
| Boiling point | 601.0±55.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble or slightly soluble in water, sparingly soluble in methanol, practically insoluble in acetonitrile. |
| pka | pKa 2.30 (Uncertain);3.39 (Uncertain) |
| Water Solubility | Soluble in water with heating (~60°C) |
| CAS DataBase Reference | 76420-72-9(CAS DataBase Reference) |
| FDA UNII | Q508Q118JM |
| EPA Substance Registry System | L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl- (76420-72-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 2 |
Enalaprilat price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 43301 | Enalaprilat analytical standard | 76420-72-9 | 25mg | $167 | 2024-03-01 | Buy |
| Alfa Aesar | J63392 | Enalaprilat | 76420-72-9 | 10mg | $143.65 | 2024-03-01 | Buy |
| Alfa Aesar | J63392 | Enalaprilat | 76420-72-9 | 50mg | $414.65 | 2024-03-01 | Buy |
| Adipogen Life Sciences | CDX-E0090-M250 | Enalaprilat ≥99%(HPLC) | 76420-72-9 | 250mg | $424 | 2021-12-16 | Buy |
| Biosynth Carbosynth | IE63755 | Enalapril maleate impurity C | 76420-72-9 | 250mg | $125 | 2021-12-16 | Buy |
Enalaprilat Chemical Properties,Uses,Production
Description
Enalaprilat is the diacid active metabolite of enalapril. As an injectable ACE inhibitor, it is reportedly useful in the treatment of uncomplicated accelerated hypertension and hypertensive emergencies. Enalaprilat is more effective in reducing blood pressure in the elderly than in the young, despite the fact that renin activity is lower in old age.
Chemical Properties
White Crystalline Solid
Originator
Merck (USA)
Uses
Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.
Uses
primary hypertension
Uses
Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor
Definition
ChEBI: Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension an heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is g ven by intravenous injection, usually as the dihydrate.
brand name
Vasotec (Biovail);Renitec.
Enalaprilat Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9456 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 961 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from Enalaprilat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-10 | Enalapril Maleate Impurity C(EP)
76420-72-9
|
US $0.00-0.00 / mg | 10mg | 90%+ | 10g | Guangzhou PI PI BIOTECH INC | |
 |
2024-04-10 | Enalapril Maleate Impurity C(EP)
76420-72-9
|
US $0.00-0.00 / mg | 10mg | 90%+ | 10g | Guangzhou PI PI BIOTECH INC | |
 |
2021-08-11 | Enalaprilat USP/EP/BP
76420-72-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Enalapril Maleate Impurity C(EP)
76420-72-9
- US $0.00-0.00 / mg
- 90%+
- Guangzhou PI PI BIOTECH INC
-
- Enalapril Maleate Impurity C(EP)
76420-72-9
- US $0.00-0.00 / mg
- 90%+
- Guangzhou PI PI BIOTECH INC
-
- Enalaprilat USP/EP/BP
76420-72-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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