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Econazole nitrate

Description References
Econazole nitrate
Econazole nitrate structure
CAS No.
24169-02-6
Chemical Name:
Econazole nitrate
Synonyms
Pargin;Amicel;Gynoryl;Micogin;SQ 13050;Micofugal;NSC 243115;Gyno-Pevaril;Gyno-prevaryl;Econazole 
CBNumber:
CB3173103
Molecular Formula:
C18H16Cl3N3O4
Formula Weight:
444.7
MOL File:
24169-02-6.mol

Econazole nitrate Properties

Melting point:
162°C
storage temp. 
Refrigerator
solubility 
chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1))
form 
powder
color 
white to off-white
Water Solubility 
<0.1 g/100 mL at 19 ºC
Merck 
14,3502
InChIKey
DDXORDQKGIZAME-UHFFFAOYSA-N
CAS DataBase Reference
24169-02-6(CAS DataBase Reference)
EPA Substance Registry System
1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]- 2-(2,4-dichlorophenyl)ethyl]-, mononitrate(24169-02-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-36/37/38
Safety Statements  26-36-36/37
WGK Germany  3
RTECS  NI4450000
HS Code  29332900
Toxicity LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P321 Specific treatment (see … on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.

Econazole nitrate price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E4632 Econazole nitrate salt 24169-02-6 5g $56.6 2018-11-20 Buy
Sigma-Aldrich E4632 Econazole nitrate salt 24169-02-6 25g $244 2018-11-20 Buy
TCI Chemical E0957 Econazole Nitrate >98.0%(HPLC)(T) 24169-02-6 5g $52 2018-11-22 Buy
TCI Chemical E0957 Econazole Nitrate >98.0%(HPLC)(T) 24169-02-6 25g $187 2018-11-22 Buy
Alfa Aesar J63173 Econazole nitrate 24169-02-6 25g $220 2018-11-13 Buy

Econazole nitrate Chemical Properties,Uses,Production

Description

Econazole nitrate is the nitrate salt form of Econazole. It belongs to imidazole-class antifungal medication sold in various places around the world including US, Canada, Western Europe, and Asia. It is usually manufactured into cream form for sale. Econazole nitrate is mainly used for the treatment of skin infections including athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch caused by fungi such as Trichophyton rubrum, Trichophyton tonsurans and Microsporum audouini. As an imidazole-class drug, Econazole nitrate takes effects through inhibiting the biosynthesis of ergosterol, a key component of fungal cell membrane, thus disrupting the normal permeability of fungal membrane. This causes leakage of essential cellular contents of fungi, further killing them.

References

http://www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Econazole
http://www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731

Chemical Properties

White to Off-White Solid

Uses

Antifungal;Ergosterol synthesis inhibition

Uses

Azole antifungal

brand name

Spectazole (Johnson & Johnson).

General Description

White crystalline powder.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.

Econazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products


Econazole nitrate Suppliers

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