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Econazole nitrate

Description References
Econazole nitrate
Econazole nitrate structure
CAS No.
24169-02-6
Chemical Name:
Econazole nitrate
Synonyms
Pargin;Amicel;Micogin;Gynoryl;SQ 13050;Micofugal;e Nitrate;NSC 243115;Gyno-Pevaril;Gyno-prevaryl
CBNumber:
CB3173103
Molecular Formula:
C18H16Cl3N3O4
Formula Weight:
444.7
MOL File:
24169-02-6.mol

Econazole nitrate Properties

Melting point:
162°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1))
form 
powder
color 
white to off-white
Water Solubility 
<0.1 g/100 mL at 19 ºC
Merck 
14,3502
InChIKey
DDXORDQKGIZAME-UHFFFAOYSA-N
CAS DataBase Reference
24169-02-6(CAS DataBase Reference)
EWG's Food Scores
2
FDA UNII
H438WYN10E
EPA Substance Registry System
Econazole mononitrate (24169-02-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P305+P351+P338-P280a-P301+P312a-P321-P332+P313-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-36/37/38
Safety Statements  26-36-36/37
WGK Germany  3
RTECS  NI4450000
HS Code  29332900
Toxicity LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)

Econazole nitrate price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E4632 Econazole nitrate salt 24169-02-6 5g $61.6 2021-12-16 Buy
Sigma-Aldrich E0050000 Econazole nitrate European Pharmacopoeia (EP) Reference Standard 24169-02-6 $190 2021-12-16 Buy
Sigma-Aldrich E4632 Econazole nitrate salt 24169-02-6 25g $266 2021-12-16 Buy
Sigma-Aldrich 1231808 Econazole nitrate United States Pharmacopeia (USP) Reference Standard 24169-02-6 250 mg $366 2021-12-16 Buy
Sigma-Aldrich 1231808 Econazole nitrate United States Pharmacopeia (USP) Reference Standard 24169-02-6 100 mg $369 2021-12-16 Buy

Econazole nitrate Chemical Properties,Uses,Production

Description

Econazole nitrate is the nitrate salt form of Econazole. It belongs to imidazole-class antifungal medication sold in various places around the world including US, Canada, Western Europe, and Asia. It is usually manufactured into cream form for sale. Econazole nitrate is mainly used for the treatment of skin infections including athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch caused by fungi such as Trichophyton rubrum, Trichophyton tonsurans and Microsporum audouini. As an imidazole-class drug, Econazole nitrate takes effects through inhibiting the biosynthesis of ergosterol, a key component of fungal cell membrane, thus disrupting the normal permeability of fungal membrane. This causes leakage of essential cellular contents of fungi, further killing them.

References

http://www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Econazole
http://www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731

Chemical Properties

White to Off-White Solid

Originator

Pevaryl,Cilag Chemie,France,1976

Uses

Antifungal;Ergosterol synthesis inhibition

Uses

Azole antifungal

Uses

Econazole nitrate is an antifungal agent of the imidazole type used in topical and vaginal preparations to prevent growth of dermatophytes, yeast, and mold.

Manufacturing Process

A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.

brand name

Spectazole (Johnson & Johnson).

Therapeutic Function

Antifungal

General Description

White crystalline powder.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.

Econazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products


Econazole nitrate Suppliers

Global( 273)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29863 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 3994 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
15377521700 +8615377521700
027-81302088 wangwendy93@gmail.com CHINA 869 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58

View Lastest Price from Econazole nitrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-22 Econazole nitrate
24169-02-6
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-30 Econazole nitrate
24169-02-6
US $2658.00 / Kg/Drum 25KG 99% 1T Baoji Guokang Bio-Technology Co., Ltd.
2021-09-29 Econazole nitrate
24169-02-6
US $0.00 / KG 1KG 99%~101.0% 800kg/month WUHAN FORTUNA CHEMICAL CO., LTD

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