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Bis(4-fluorophenyl)-methanone

Bis(4-fluorophenyl)-methanone Structure
Bis(4-fluorophenyl)-methanone structure
CAS No.
345-92-6
Chemical Name:
Bis(4-fluorophenyl)-methanone
Synonyms
4,4-DIFLUOROBENZOPHENONE;BDF;4,4'-Difluorobenzophenone;Difluorobenzophenone;4,4’-difluoro-benzophenon;BIS(4-FLUOROPHENYL) KETONE;Bis(4-fluorophenyl)-;4,4' -difluorophenone;p-Fluorophenyl ketone;-Difluorobenzophenone
CBNumber:
CB3179589
Molecular Formula:
C13H8F2O
Molecular Weight:
218.2
MDL Number:
MFCD00000353
MOL File:
345-92-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:02:30
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Bis(4-fluorophenyl)-methanone Properties

Melting point 102-105 °C (lit.)
Boiling point 137°C (3 torr)
Density 1.2543 (estimate)
vapor pressure 0.005Pa at 20℃
Flash point 170-172°C/10mm
storage temp. Sealed in dry,Room Temperature
solubility Insoluble in water
form Crystalline Powder
color White to slightly yellow
Water Solubility 8.757mg/L at 20℃
BRN 516231
InChI 1S/C13H8F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8H
InChIKey LSQARZALBDFYQZ-UHFFFAOYSA-N
SMILES Fc1ccc(cc1)C(=O)c2ccc(F)cc2
LogP 3.37 at 20℃
CAS DataBase Reference 345-92-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 88BNC11B9C
NIST Chemistry Reference 4,4'-Difluorobenzophenone(345-92-6)
EPA Substance Registry System 4,4'-Difluorobenzophenone (345-92-6)
UNSPSC Code 77101502
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H315-H319-H335-H411
Precautionary statements  P273-P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,N,Xn
Risk Statements  36/37/38-51/53-22
Safety Statements  26-37/39-36-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  DJ0685000
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29143990
Storage Class 13 - Non Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
0
2 0

Bis(4-fluorophenyl)-methanone price More Price(80)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 115495 4,4′-Difluorobenzophenone 99% 345-92-6 25g $116 2026-04-30 Buy
Sigma-Aldrich PHR2117 4,4′-Difluorobenzophenone Pharmaceutical Secondary Standard; Certified Reference Material 345-92-6 200mg $165 2026-04-30 Buy
TCI Chemical D1797 4,4'-Difluorobenzophenone >99.0%(GC) 345-92-6 25g $31 2026-04-30 Buy
TCI Chemical D1797 4,4'-Difluorobenzophenone >99.0%(GC) 345-92-6 100g $63 2026-04-30 Buy
TRC TRC-D445430-25G 4,4'-Difluorobenzophenone 345-92-6 25g $130 2026-06-03 Buy
Product number Packaging Price Buy
115495 25g $116 Buy
PHR2117 200mg $165 Buy
D1797 25g $31 Buy
D1797 100g $63 Buy
TRC-D445430-25G 25g $130 Buy

Bis(4-fluorophenyl)-methanone Chemical Properties, Uses, Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

4,4′-Difluorobenzophenone has been used in the study of thermal stability, water uptake and proton conductivity of carboxylated, carboxylated/sulfonated, and crosslinked membranes.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 540, 1968 DOI: 10.1021/ja01004a087

General Description

4,4′-Difluorobenzophenone is typically used as a starting material for the preparation of polyetheretherketone (PEEK) polymer, a high-temperature thermoplastic, which finds wide use in dentistry as well as in automotive, oil industries, etc.

Synthesis

Mix 200g of fluorobenzene with 65g of anhydrous aluminum trichloride, cool to 0-5, add 100g of p-fluorotrichloromethylbenzene dropwise reaction for 20min, get 4,4'-difluorophenyl dichloromethane;

Add 4,4'-difluorophenyl dichloromethane to 600g of water mixing, heating To the azeotropic temperature at the same time recycling fluorobenzene 140g, reaction 5h, cooling to room temperature, filtration, drying to get light yellow solid crude 102g, using 200g methanol recrystallization, filtration, washing, drying, to get the melting point of 107-108 white crystals 92g, the purity of gas chromatography analysis of 99.9%, the yield is 90%. Detected by 1H-NMR: 7.28 (4H, t, hydrogen adjacent to the fluorine on the benzene ring); 7.81 (4H, m, hydrogen adjacent to the carbonyl on the benzene ring), which is consistent with the structure of 4,4'-difluorobenzophenone.

Bis(4-fluorophenyl)-methanone synthesis

1093981-40-8
345-92-6
Synthesis of Bis(4-fluorophenyl)-methanone from Benzene, 1,1'-(azidomethylene)bis[4-fluoro-

Bis(4-fluorophenyl)-methanone Preparation Products And Raw materials

Raw materials

Fluorobenzene (2-Naphtyl)tributylstannane 4-Fluoro-(tri-n-butylstannyl)benzene 4,4'-Difluorodiphenylmethane 4,4'-Difluorobenzhydrol
4,4'-Dichlorobenzophenone 4-Fluorobenzoyl chloride Dimethyl sulfone 4-Fluorobenzenediazonium tetrafluoroborate 4-Fluorobenzaldehyde

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Preparation Products

(4-(4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl)phenyl)methanol 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) 4-Fluoro-4'-nitrobenzophenone Bis-(4-fluoro-phenyl)-phenyl-methanol 1,1-Bis(4-fluorophenyl)-1-butene

Bis(4-fluorophenyl)-methanone Suppliers

Global Suppliers ( 727)
Supplier Tel Email Country ProdList Advantage
SINO HIGH(CHINA)CO.,LTD. 15295090350 13914336446 chang@sinohighchem.com China 40 58
Shijiazhuang Jianxin Biotechnology Co., LTD 0311-1906231-3169 19062313169 19062313169@163.com China 399 58
East Star Biotech (Suzhou) Co., Ltd. 0512-62620298 17520198886 18636423@qq.com China 29 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 15995069468 15995069468 3398435160@qq.com China 300 58
Nantong Subei Chemical Raw Materials Co., Ltd. 0513-85290972 18762756250 ntsbhg@163.com China 9277 58
WEIFANG DAYOO BIOCHEMICAL CO.,LTD 13305362020 sales@dayoochemical.com China 28 58
Jiangsu Derui Pharmaceutical Co., Ltd 0512-62620298 17037718886 18636423@qq.com China 18 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Changzhou Sunlight Pharmaceutical Co., Ltd 519-83131668 15995063688 info@sunlightchem.com China 100 69
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
SINO HIGH(CHINA)CO.,LTD. 58
Shijiazhuang Jianxin Biotechnology Co., LTD 58
East Star Biotech (Suzhou) Co., Ltd. 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 58
Nantong Subei Chemical Raw Materials Co., Ltd. 58
WEIFANG DAYOO BIOCHEMICAL CO.,LTD 58
Jiangsu Derui Pharmaceutical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Changzhou Sunlight Pharmaceutical Co., Ltd 69
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

Related articles

View Latest Price from Bis(4-fluorophenyl)-methanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4′-difluorobenzophenone pictures 2026-09-15 4,4′-difluorobenzophenone
345-92-6
 $10.00 1ASSAYS 99% 10 ton RongNa Biotechnology Co.,Ltd
Bis(4-fluorophenyl)-methanone pictures 2026-09-15 Bis(4-fluorophenyl)-methanone
345-92-6
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
4,4'-Difluorobenzophenone pictures 2026-09-15 4,4'-Difluorobenzophenone
345-92-6
 1KG 99% 200mt Jinan Finer Chemical Co., Ltd

Bis(4-fluorophenyl)-methanone Spectrum

Bis(4-fluorophenyl)-methanone(345-92-6)MSBis(4-fluorophenyl)-methanone(345-92-6)1HNMRBis(4-fluorophenyl)-methanone(345-92-6)13CNMRBis(4-fluorophenyl)-methanone(345-92-6)IR1Bis(4-fluorophenyl)-methanone(345-92-6)IR2Bis(4-fluorophenyl)-methanone(345-92-6)Raman

345-92-6 (Bis(4-fluorophenyl)-methanone) Related Search:

1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7,8-dinitro- Vortioxetine Impurity 32 4-ethenyl-1,2-dimethyl-benzene Vernakalant-d6 HCl Vernakalant Impurity 1 ((3S,1'S,2'S)-Isomer) HCl
Doxofylline Impurity 11 16-Hydroxy Capsaicin 3,4-Dimethylbenzene-1-carbonyl chloride 3-Methoxybenzalacetone 2,4'-Difluorobenzophenone
3,4-Difluorobenzophenone 2,4-Difluorobenzophenone 3,3'-Difluorobenzophenone Benzophenone 4,4'-Difluorodiphenylmethane
p-Fluorotoluene Diphenylmethane 2,6-Difluorobenzophenone

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Benzophenone, 4,4'-difluoro- bis(4-fluorophenyl)-methanon Bis(p-fluorophenyl) ketone bis(p-fluorophenyl)ketone Di-p-fluorophenyl ketone di-p-fluorophenylketone Methanone, bis(4-fluorophenyl)- p,p’-difluorobenzophenone p,p'-Difluorobenzophenone 4,4'-Difluorbenzophenone DI(4-FLUOROPHENYL)METHANONE LABOTEST-BB LT00159767 BIS-(4-FLUORO-PHENYL)-METHANONE 4,4'-Dddifluorobenzophenone 4,4'-Difluorobnzophenone 4,4'-Difluorobenzophenone/Bis(4-Fluorophenyl)Methanone 4,4'-Difluorobenzophenone, 98+% 4,4''-DIFLURO BENZOPHENONE 4,4'-Difluorobenzophenone99% 4,4''-DIFLUOROBENZOPHENONEFLUNARIZINE 4, 4 - two fluorine diphenyl ketone 4,4'- twofluorine twoBenzophenone 4,4'-Difluorobenzophenone, 97+% 1,1'-Carbonylbis(4-fluorobenzene) 4,4'-Carbonylbis(1-fluorobenzene) 4,4'-Carbonylbis(fluorobenzene) Bis(4-fluorophenyl)- 4.4'-Difluarobenzophonone 4,4'-Difluorobenzophenone≥ 99% (GC) 1,1-di(p-fluorophenyl)-ketone Flunarizine Impurity 10 4'-Difluorobenzophenone (4,4-difluoro-1-cyclohexa-1,5-dienyl)-phenylmethanone Bis(4-fluorophenyl)-methanone 345-92-6 4,4'-Difluorobenzophenone, 99%, for synthesis 4,4'-Difluorobenzophenone > 4,4' -difluorophenone High Quality 4, 4′-Difluorobenzophenone p-Fluorophenyl ketone Difluorobenzophenone -Difluorobenzophenone Benzophenone,4,4'-difluoro-Chemicalbook 4,4'-difluoro-benzophenon 4,4′-Difluorobenzophenone, CAS 345-92-6 4,4’-difluoro-benzophenon BIS(4-FLUOROPHENYL) KETONE 4,4'-Difluorobenzophenone 4,4-DIFLUOROBENZOPHENONE BDF 345-92-6 3450-92-6 C13H8F2O Benzophenones (for High-Performance Polymer Research) Reagent for High-Performance Polymer Research C13 to C14 Carbonyl Compounds Building Blocks Organic Building Blocks