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A 769662

A 769662 structure

CAS No.: 844499-71-4

Chemical Name:: A 769662

Synonyms: CS-18;A 769662;A-769622;A-769662, >=98%;A-769662/A769662;A 769662 ISO 9001：2015 REACH;A 769662 (This product is unavailable in the U.S.);4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6;4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile;4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile

CBNumber:: CB31871930

Molecular Formula:: C20H12N2O3S

Molecular Weight:: 360.39

MDL Number:: MFCD11977269

MOL File:: 844499-71-4.mol

Last updated:2023-06-30 15:45:59

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A 769662 Properties

Melting point	263 - 266oC
Boiling point	630.1±55.0 °C(Predicted)
Density	1.56
Flash point	334.9℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form	solid
pka	4.50±1.00(Predicted)
color	Beige
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
FDA UNII	P68477CD2C

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H312-H332-H319

Precautionary statements

P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P

Safety Statements

24/25

HS Code

29333990

NFPA 704

	0
3		0

A 769662 price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11900	A-769662 ≥98%	844499-71-4	5mg	$69	2024-03-01	Buy
Cayman Chemical	11900	A-769662 ≥98%	844499-71-4	10mg	$131	2024-03-01	Buy
Cayman Chemical	11900	A-769662 ≥98%	844499-71-4	50mg	$449	2024-03-01	Buy
Tocris	3336	A769662 ≥98%(HPLC)	844499-71-4	50	$899	2021-12-16	Buy
Tocris	3336	A769662 ≥98%(HPLC)	844499-71-4	10	$214	2021-12-16	Buy

Product number	Packaging	Price	Buy
11900	5mg	$69	Buy
11900	10mg	$131	Buy
11900	50mg	$449	Buy
3336	50	$899	Buy
3336	10	$214	Buy

A 769662 Chemical Properties,Uses,Production

Description

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC₅₀ = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr¹⁷². A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

Uses

A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.

Definition

ChEBI: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile is a member of biphenyls.

Biological Activity

Potent, reversible AMP-activated protein kinase (AMPK) activator (EC 50 = 0.8 μ M) that displays selectivity towards β 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC 50 = 3.2 μ M) and decreases plasma glucose and triglyceride levels in vivo .

storage

+4°C

References

1) Scott et al. (2008), Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes; Cell Biol., 15 1220 2) Cool et al. (2006), Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome; Cell Metab., 3 403 3) Zhou et al. (2009), Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase on 3T3-L1 adipogenesis; Biol. Pharm. Bull., 32?993 4) Vazquez-Martin et al. (2012) Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells; Cell Cycle, 11 974 5) Ducommun et al. (2014) Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662; Am. J. Physiol. Endocrinol. Metab., 306 E688

A 769662 Preparation Products And Raw materials

Raw materials

Preparation Products

A 769662 Suppliers

Global( 146)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7838	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei xin bonus chemical co. LTD	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from A 769662 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-09-27	A 769662 844499-71-4	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
	2021-07-02	4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile 844499-71-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

A 769662
844499-71-4
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile
844499-71-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

A 769662 Spectrum

A 769662(844499-71-4)¹HNMR

844499-71-4(A 769662)Related Search:

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM BIO Glibenclamide (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE 2,2-diphenyl-1-picrylhydrazyl

RUETASOLV BP 4103 - MIXTURE OF ISOMERES ISOPROPYLBIPHENYLS. FOR FURTHER DETAILS PLEASE INQUIRE AT MARKETING CONTACTS. SPECIALITY CHEMICALS 4,4'-Biphenol 3-PHENYLPHENOL 4-Phenylphenol BML-275

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A 769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo- A-769662/A769662 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitri A-769622 A-769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile A-769662, >=98% 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboni A 769662 ISO 9001：2015 REACH 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile CS-18 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6 4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile A 769662 (This product is unavailable in the U.S.) 4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 844499-71-4 C20H12N2O3S Inhibitors Akt mTOR PI3K APIs Signalling