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DGAT-3

DGAT-3 structure

CAS No.: 701232-20-4

Chemical Name:: DGAT-3

Synonyms: DGAT-3;CS-120;T-863;T 863;trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid;trans-Cyclohexaneacetic-acid,-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl];trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-;2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid;Diglyceride acyltransferase,inhibit,acyl-CoA:cholesterol acyltransferase,T 863,T-863,T863,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,Diacylglycerol acyltransferase

CBNumber:: CB31872285

Molecular Formula:: C22H26N4O3

Molecular Weight:: 394.47

MDL Number:: MFCD11977270

MOL File:: 701232-20-4.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:04

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DGAT-3 Properties

Boiling point	616.6±55.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble15mg/mL (clear solution)
pka	4.72±0.10(Predicted)
form	powder
color	white to beige
FDA UNII	OF68Z8HK6V

SAFETY

Risk and Safety Statements

WGK Germany	3

DGAT-3 price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0539	T863 ≥98% (HPLC)	701232-20-4	5mg	$142	2024-03-01	Buy
Sigma-Aldrich	SML0539	T863 ≥98% (HPLC)	701232-20-4	25mg	$334.2	2024-03-01	Buy
Cayman Chemical	25807	T-863 ≥95%	701232-20-4	1mg	$40	2024-03-01	Buy
Cayman Chemical	25807	T-863 ≥95%	701232-20-4	5mg	$129	2024-03-01	Buy
Cayman Chemical	25807	T-863 ≥95%	701232-20-4	10mg	$236	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0539	5mg	$142	Buy
SML0539	25mg	$334.2	Buy
25807	1mg	$40	Buy
25807	5mg	$129	Buy
25807	10mg	$236	Buy

DGAT-3 Chemical Properties,Uses,Production

Uses

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

to provide the opportunity to precisely control the DGAT inhibition
to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
to specifically block neutral?lipid synthesis?and lipid droplet formation in HT-1080 cells
to block lipid droplet (LD) formation

Biological Activity

diacylglycerol acyltransferase (dgat1) inhibitor

Biochem/physiol Actions

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

DGAT-3 Preparation Products And Raw materials

Raw materials

Preparation Products

DGAT-3 Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55

DGAT-3 Spectrum

DGAT-3(701232-20-4)¹HNMR

701232-20-4(DGAT-3)Related Search:

N,N-Dimethylaniline trans-4-Aminocyclohexanol

DGAT-3 Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans- trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid T-863;T 863 CS-120 trans-Cyclohexaneacetic-acid,-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl] Diglyceride acyltransferase,inhibit,acyl-CoA:cholesterol acyltransferase,T 863,T-863,T863,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,Diacylglycerol acyltransferase 701232-20-4