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Liothyronine sodium

Liothyronine sodium
Liothyronine sodium structure
CAS No.
55-06-1
Chemical Name:
Liothyronine sodium
Synonyms
Ibiot;Cyomel;T3, NA;Cytobin;Cynomel;Cytomine;Triostat;Sodium T3;Tertroxin;T3 Sodium
CBNumber:
CB3195390
Molecular Formula:
C15H11I3NNaO4
Formula Weight:
672.96
MOL File:
55-06-1.mol

Liothyronine sodium Properties

Melting point:
205 °C (dec.)(lit.)
alpha 
20 º (c=2,alcohol/1.2N HCl)
RTECS 
YP2836500
storage temp. 
-20°C
solubility 
4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
form 
powder
color 
White to Pale Brown
Water Solubility 
Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.
Sensitive 
Light Sensitive
Merck 
5510
BRN 
8179867
CAS DataBase Reference
55-06-1(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
GCA9VV7D2N
NCI Dictionary of Cancer Terms
liothyronine sodium; Triostat
NCI Drug Dictionary
liothyronine sodium
ATC code
H03AA02
EPA Substance Registry System
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (55-06-1)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  22-24/25-36
WGK Germany  3
3-8-10
HS Code  29379000

Liothyronine sodium price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T2752 3,3′,5-Triiodo-L-thyronine sodium salt ≥95% (HPLC) 55-06-1 100mg $52.5 2020-08-18 Buy
Sigma-Aldrich T2752 3,3′,5-Triiodo-L-thyronine sodium salt ≥95% (HPLC) 55-06-1 250mg $146 2020-08-18 Buy
Sigma-Aldrich L0700000 Liothyronine sodium European Pharmacopoeia (EP) Reference Standard 55-06-1 $190 2021-03-22 Buy
Alfa Aesar J63312 3,3',5'-Triiodo-L-thyronine sodium salt 55-06-1 1g $206 2020-06-24 Buy
Alfa Aesar J63312 3,3',5'-Triiodo-L-thyronine sodium salt 55-06-1 500mg $115 2020-06-24 Buy

Liothyronine sodium Chemical Properties,Uses,Production

Chemical Properties

white to beige powder

Originator

Cytomel,SKF,US,1956

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Uses

cytochrome P450 inhibitor, Ca antagonist, anesthetic (local)

Definition

ChEBI: The sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma.

Indications

Liothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3 alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.

Manufacturing Process

The 3,5-diiodo compound used as a starting material is a known material and may be prepared by the method in British Patents 643,089 and 671,070 and in the Journal of the Chemical Society, London, 1949, page 3424.
Synthesis: L-diiodo thyronine (1.05 g) is dissolved in ammonia (specific gravity 0.880) (40 ml) and methanol (40 ml) and iodinated slowly with shaking with N-iodine in KI solution at room temperature. After iodination,most of the ammonia and methanol are removed by evaporation under diminished pressure, water is added to the original volume, the solution is heated to 60°C and brought to pH 4 with hydrochloric acid. A crystalline precipitate is obtained which after cooling to room temperature is collected and washed with water. At this stage, the crude triiodo thyronine is contaminated with thyroxine and a little unchanged diiodo thyronine.
Purification: The crude precipitate is dissolved in boiling 2N HCl (300 ml) and filtered from the relatively insoluble thyroxine hydrochloride. The hot filtrate is brought to pH 4 with 5N NaOH and triiodo thyronine again separates; after chilling at 0° to 4°C it is collected, washed with water and dried. The yield of triiodo thyronine is 70 to 75% of the theoretical. This triiodo thyronine still contains some thyroxine (about 10%).
The final purification consists of chromatographic separation of thyroxine and triiodo thyronine on a kieselguhr column using 20% chloroform in n-butanol equilibrated with 0.5N NaOH as the developing solvent. 80 to 100 mg triiodo thyronine is purified during each run on a 50 g kieselguhr column. Pure Ltriiodo thyronine has MP 236° to 237°C (dec.) and [α]D29.5° = +21.5 in a 4.75% solution in a mixture of 1 part of N HCl and 2 parts of ethanol. Liothyronine is commonly used as the sodium salt.

brand name

Thyroid hormone Cytomel (King); Triostat (Jones).

Therapeutic Function

Thyroid hormone

Veterinary Drugs and Treatments

Because of its shorter duration of action, liothyronine is generally not considered the drug of first choice in treating hypothyroidism. Infrequently, animals not responding to levothyroxine may respond to liothyronine.

Liothyronine sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Liothyronine sodium Suppliers

Global( 241)Suppliers
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Suzhou Ryan Pharmachem Technology Co.,Ltd.
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Shanghai Longyu Biotechnology Co., Ltd.
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View Lastest Price from Liothyronine sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Liothyronine sodium
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-30 Liothyronine sodium
55-06-1
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-30 3,3',5-Triiodothyronine sodium salt
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Liothyronine sodium Spectrum


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