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Boc-N-methyl-L-leucine

Boc-N-methyl-L-leucine structure

CAS No.: 53363-89-6

Chemical Name:: Boc-N-methyl-L-leucine

Synonyms: Tyr(Me);BOC-MELEU-OH;BOC-LEU(ME)-OH;BOC-L-MELEU-OH;BOC-ALA(TBU)-OH;BOC-N-ME-LEU-OH;BOC-N-ME-LEUCINE;Boc-N-Me-L-Leu-OH;BOC-BETA-TBU-ALA-OH;BOC-BETA-TBU-ALANINE

CBNumber:: CB3197622

Molecular Formula:: C12H23NO4

Molecular Weight:: 245.32

MDL Number:: MFCD00038522

MOL File:: 53363-89-6.mol

MSDS File:: SDS

Last updated:2023-10-23 14:04:04

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Boc-N-methyl-L-leucine Properties

Melting point	55-60 °C
Boiling point	338.2±21.0 °C(Predicted)
Density	1.053±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
pka	4.04±0.21(Predicted)
optical activity	[α]20/D 36±2°, c = 1% in methylene chloride
BRN	2373250
InChI	InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
InChIKey	YXJFAOXATCRIKU-VIFPVBQESA-N
SMILES	C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference	53363-89-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2924 19 00
HazardClass	IRRITANT

Boc-N-methyl-L-leucine price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53083	Boc-N-Me-Leu-OH Novabiochem?	53363-89-6	5G	$132	2023-01-07	Buy
Sigma-Aldrich	15446	Boc-N-Me-Leu-OH ≥99.0% (sum of enantiomers, TLC)	53363-89-6	5g	$360	2023-01-07	Buy
Usbiological	264714	Boc-N-methyl-L-leucine	53363-89-6	2g	$333	2021-12-16	Buy
Usbiological	236540	Boc-N-methyl-L-leucine 98+%	53363-89-6	1g	$170	2021-12-16	Buy
Biosynth Carbosynth	FB47462	Boc-N-methyl-L-leucine	53363-89-6	25g	$180	2021-12-16	Buy

Product number	Packaging	Price	Buy
8.53083	5G	$132	Buy
15446	5g	$360	Buy
264714	2g	$333	Buy
236540	1g	$170	Buy
FB47462	25g	$180	Buy

Boc-N-methyl-L-leucine Chemical Properties,Uses,Production

Description

Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.

Uses

Boc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Biological Activity

Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.

References

https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay

Boc-N-methyl-L-leucine synthesis

Synthesis of Boc-N-methyl-L-leucine from BOC-L-Leucine and Iodomethane

Boc-N-methyl-L-leucine Preparation Products And Raw materials

Raw materials

BOC-L-Leucine Iodomethane

Preparation Products

Boc-N-methyl-L-leucine Suppliers

Global( 159)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8618980456393	daisy@enlaibio.com	China	1369	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Jinan Honest Pharm Co., Ltd	+8615318812076	zpy8217@163.com	China	286	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Sichuan Jiaying Lai Technology Co.,LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Jinan Honest Pharm Co., Ltd	58

View Lastest Price from Boc-N-methyl-L-leucine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-04-25	Boc-N-Me-L-Leu-OH 53363-89-6	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
	2020-01-06	BOC-N-Me-leu-OH 53363-89-6	US $1.00 / g	1g	98%	100KG	Sichuan Jiaying Lai Technology Co.,LTD

Boc-N-Me-L-Leu-OH
53363-89-6
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-N-Me-leu-OH
53363-89-6
US $1.00 / g
98%
Sichuan Jiaying Lai Technology Co.,LTD

Boc-N-methyl-L-leucine Spectrum

Boc-N-methyl-L-leucine(53363-89-6)MS

53363-89-6(Boc-N-methyl-L-leucine)Related Search:

L-Leucine N-CARBOBENZOXY-DL-LEUCINE Methylparaben Thiophanate-methyl BOC-L-Leucine

Boc-Aib-OH L-tert-Leucine Bensulfuron methyl Methyl acrylate N-Carbobenzyloxyglycine

Kresoxim-methyl Methyl BOC-GLY-LEU-OH FMOC-ARG(ME,PBF)-OH N-Boc-L-trans-4,5-Methanoproline

BOC-D-ALLO-ILE-OH BOC-D-TYR(ET)-OH FMOC-CHA-OH

1of4

N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE BOC-BETA-TBU-ALANINE BOC-BETA-TBU-ALA-OH BOC-BETA-T-BUTYL-L-ALANINE BOC-ALA(TBU)-OH BOC-N-ME-LEUCINE BOC-N-ME-LEU-OH BOC-N-METHYL-L-LEUCINE BOC-N-METHYL-L-LEU-OH BOC-MELEU-OH BOC-NEOPENTYLGLYCINE BOC-(NEOPENTYL)GLY-OH BOC-N-ALPHA-METHYL-L-LEUCINE BOC-L-BETA-T-BUTYLALANINE BOC-LEU(ME)-OH BOC-L-NEOPENTYLGLYCINE BOC-L-MELEU-OH BOC-T-BUTYL-L-ALANINE N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-LEUCINE DANSYL-L-GLUTAMIC ACID BIS(CYCLOHEXYLAMMONIUM) NALPHA-tert-Butoxycarbonyl-N-methyl-L-leucine N-tert-Butyloxycarbonyl-N-methyl-L-leucine N-(tert-butoxycarbonyl)-N-methyl-L-leucine L-Leucine, N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl- (S)-2-((tert-butoxycarbonyl)(Methyl)aMino)-4-Methylpentanoic acid Tyr(Me) Boc-N-Me-L-Leu-OH Boc-N-Me-Leu-OH Boc-N-Methyl Leucine Boc-N-methyl-L-leucine98+% N-α-t-butoxycarbonyl-β-t-butyl-L-alanine (Tert-Butoxy)Carbonyl N-Me-Leu-OH (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4-methylpentanoic acid (2S)-4-methyl-2-[methyl-[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid Boc-N-L-methylleucine Boc-N-methyl-L-leucine USP/EP/BP 2-((TERT-BUTOXYCARBONYL)(METHYL)AMINO)-4-METHYLPENTANOIC ACID N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-leucine N-BOC-N-Methyl-L-leucine BOC-N-methyl tert leucine 53363-89-6 Peptide Synthesis N-Methyl Amino Acids Unnatural Amino Acid Derivatives Specialty Synthesis amino acids Amino Acid Derivatives N-Methyl Amino Acids