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GUANETHIDINE SULFATE

GUANETHIDINE SULFATE
GUANETHIDINE SULFATE structure
CAS No.
645-43-2
Chemical Name:
GUANETHIDINE SULFATE
Synonyms
GUANETHIDINE SULFATE;Guanethidine Sulphae;GUANETHIDINE MONOSULFATE;GUANETHIDINEMONOSULFATE,USP;GUANETHIDINE MONOSULFATE (1:1);Guanethidine Monosulfate (200 mg);1-(2-Guanidinoethyl)octahydroazocine;2-(1-Azacyclooctyl)ethylguanidine monosulfate;n-(2-guanidinoethyl)heptamethyleniminesulfate;2-(octahydro-1-azocinyl)ethylguanidinesulphate
CBNumber:
CB3200665
Molecular Formula:
C10H24N4O4S
Formula Weight:
296.39
MOL File:
645-43-2.mol

GUANETHIDINE SULFATE Properties

storage temp. 
2-8°C
solubility 
Freely soluble in water, practically insoluble in ethanol (96 per cent)
InChIKey
YUFWAVFNITUSHI-UHFFFAOYSA-N
CAS DataBase Reference
645-43-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22
Safety Statements  25-36
RTECS  MF3150000
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:

GUANETHIDINE SULFATE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich BP181 Guanethidine monosulfate British Pharmacopoeia (BP) Reference Standard 645-43-2 bp181 $185 2018-11-23 Buy
Sigma-Aldrich 1301801 Guanethidine monosulfate United States Pharmacopeia (USP) Reference Standard 645-43-2 200mg $338.1 2018-11-20 Buy
Cayman Chemical 16217 Guanethidine (sulfate) ≥95% 645-43-2 1g $198 2018-11-13 Buy
Cayman Chemical 16217 Guanethidine (sulfate) ≥95% 645-43-2 100mg $45 2018-11-13 Buy
Cayman Chemical 16217 Guanethidine (sulfate) ≥95% 645-43-2 500mg $124 2018-11-13 Buy

GUANETHIDINE SULFATE Chemical Properties,Uses,Production

Chemical Properties

GUANETHIDINE SULFATE is colourless, crystalline powder

Uses

Antihypertensive.

Definition

ChEBI: A organic sulfate salt obtained from guanethidine and sulfuric acid in a 1:1 ratio.

brand name

Ismelin (Novartis).

General Description

Guanethidinemonosulfate, [2-(hexahydro-1 (2H)-azocinyl)ethyl]guanidinesulfate (Ismelin sulfate), is a white, crystalline materialthat is very soluble in water. It was one of a series ofguanidine compounds prepared in the search for potent antitrypanosomalagents. There is an absence of CNS effects,such as depression, because the drug is highly polar anddoes not easily cross the blood-brain barrier. Guanethidinemonosulfate produces a gradual, prolonged fall in bloodpressure. Usually, 2 to 7 days of therapy are required beforethe peak effect is reached, and usually, this peak effectis maintained for 3 or 4 days. Then, if the drug is discontinued,the blood pressure returns to pretreatment levelsover a period of 1 to 3 weeks. Because of this slow onsetand prolonged duration of action, only a single daily doseis needed.

Clinical Use

Guanethidine monosulfate is metabolized by microsomalenzymes to 2-(6-carboxyhexylamino)ethylguanidine andguanethidine N-oxide . Both metabolites havevery weak antihypertensive properties. Guanethidine monosulfateis taken up by the amine pump located on theneuronal membrane and retained in the nerve, displacingnorepinephrine from its storage sites in the neuronal granules.The displaced norepinephrine is metabolized to homovanillicacid by mitochondrial MAO, depleting the nerveending of the neurotransmitter. The usefulness of guanethidinemonosulfate also resides in the fact that once it is takenup by the nerve, it produces a sympathetic blockade by inhibitingrelease of nonepinephrine that would occur on neuronalmembrane response to stimulation29 by the nerveaction potential. Guanethidine monosulfate stored in thegranules is released by the nerve action potential but hasvery low intrinsic activity for the adrenergic receptors on thepostjunctional membrane. Moderate doses for a prolongedperiod or large doses may produce undesirable side effectsby causing neuromuscular blockade and adrenergic nerveconduction blockade.

GUANETHIDINE SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products


GUANETHIDINE SULFATE Suppliers

Global( 59)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 3911 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Wuhan Kai Lun new material Chemical Co Ltd 025-87787262;15071332665
025-87787262 wshun@51chemall.com China 499 58
Suizhou Jiake Biological Engineering Co., Ltd. 18008664168,0722-3632789/18008664499,0722-3632989
0722-3255139 QQ:2549463910;2286801987 2549463910@qq.com China 97 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19981 64
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9851 79
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
+86 21 50676805 contact@trustwe.com China 9923 58
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7560 61

View Lastest Price from GUANETHIDINE SULFATE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Clopidogrel sulfate
645-43-2
US $1.00 / kg 1kg 99% Customized career henan chemical co

GUANETHIDINE SULFATE Spectrum


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