3-FLUORO-6-NITRO-O-XYLENE
- CAS No.
- 1736-87-4
- Chemical Name:
- 3-FLUORO-6-NITRO-O-XYLENE
- Synonyms
- -FLUORO-6-NITRO-O-XYLENE;3-FLUORO-6-NITRO-O-XYLENE;2,3-Dimethyl-4-fluoronitrobenzene;4-fluoro-2,3-dimethyl nitrobenzene;3-FLUORO-6-NITRO-1,2-DIMETHYLBENZENE;1-FLUORO-2,3-DIMETHYL-4-NITROBENZENE;1,2-Dimethyl-3-fluoro-6-nitrobenzene;2,3-dimethyl-4-fluoro-1-nitro-benzene;Benzene,1-fluoro-2,3-diMethyl-4-nitro-;3-Fluoro-1,2-dimethyl-6-nitrobenzene,98%
- CBNumber:
- CB3204012
- Molecular Formula:
- C8H8FNO2
- Molecular Weight:
- 169.15
- MDL Number:
- MFCD05663712
- MOL File:
- 1736-87-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H311-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280h-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2909309090 | |||||||||
| NFPA 704 |
|
3-FLUORO-6-NITRO-O-XYLENE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5187 | 2,3-Dimethyl-4-fluoronitrobenzene >98.0%(GC) | 1736-87-4 | 1g | $47 | 2024-03-01 | Buy |
| TCI Chemical | D5187 | 2,3-Dimethyl-4-fluoronitrobenzene >98.0%(GC) | 1736-87-4 | 5g | $141 | 2024-03-01 | Buy |
| Alfa Aesar | H32557 | 3-Fluoro-1,2-dimethyl-6-nitrobenzene, 98% | 1736-87-4 | 1g | $124 | 2021-12-16 | Buy |
| Alfa Aesar | H32557 | 3-Fluoro-1,2-dimethyl-6-nitrobenzene, 98% | 1736-87-4 | 5g | $414 | 2021-12-16 | Buy |
| Alfa Aesar | H32557 | 3-Fluoro-1,2-dimethyl-6-nitrobenzene, 98% | 1736-87-4 | 250mg | $45.5 | 2021-12-16 | Buy |
3-FLUORO-6-NITRO-O-XYLENE Chemical Properties,Uses,Production
Uses
3-Fluoro-6-nitro-o-xylene is mainly used as an intermediate in organic synthesis, especially in the fields of pharmaceutical and pesticide chemistry.
Synthesis
443-82-3
1736-87-4
Example 16: Synthesis of 2-(2,3-dimethyl-4-nitrophenylamino)-2-methylpropan-1-ol 1. fuming nitric acid (1.4 g, 20.3 mmol) was cooled to 0 °C and slowly added to acetic anhydride (2.89 g, 28.4 mmol). 2. the above solution was added dropwise to a cooled (0 °C) solution of 3-fluoro-1,2-dimethylbenzene (1.0 g, 8.1 mmol) in acetic anhydride (4 ml) within 10 min. 3. The reaction mixture was stirred at 0 °C for 25 min and then slowly poured into ice water. 4. The aqueous phase was extracted with EtOAc (3×) and the organic phases were combined and washed sequentially with saturated aqueous solution of dilute NaHCO3 and brine. 5. The organic phase was dried over anhydrous Na2SO4, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (mobile phase: hexane) to obtain 2,3-dimethyl-4-fluoro-1-nitrobenzene 0.74 g (54% yield) as a yellow oil, which was crystallized after standing. 6. The above nitro compound (0.576 g, 3.4 mmol) was mixed with 2-amino-2-methylpropanol (0.61 g, 6.8 mmol) in a reaction tube, sealed and immersed in an oil bath at 160 °C for 5 days. 7. TLC monitoring (unfolding agent: hexane) showed raw material remaining. The reaction mixture was cooled and diluted with EtOAc. 8. Purification by fast silica gel column chromatography (dry on sample; eluent: hexane/EtOAc=6:4) recovered the feedstock 2,3-dimethyl-4-fluoro-1-nitrobenzene 0.34 g (59% recovery) and afforded the target product 2-(2,3-dimethyl-4-nitrophenylamino)-2-methylpropan-1-ol 0.20 g (61% yield based on recovered feedstock).
References
[1] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 38-39
[2] Journal of the Chemical Society, 1963, p. 5554 - 5556
3-FLUORO-6-NITRO-O-XYLENE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20203 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
View Lastest Price from 3-FLUORO-6-NITRO-O-XYLENE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2023-12-26 | 3-FLUORO-6-NITRO-O-XYLENE
1736-87-4
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-04-12 | 3-FLUORO-6-NITRO-O-XYLENE
1736-87-4
|
US $15.00 / Kg/Bag | 1Kg/Bag | 99.8% | Weekly supply of 1000KG | Wuhan Dujiang Industrial Co., Ltd. | |
 |
2020-02-26 | 3-Fluoro-6-nitro-o-xylene
1736-87-4
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-FLUORO-6-NITRO-O-XYLENE
1736-87-4
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-FLUORO-6-NITRO-O-XYLENE
1736-87-4
- US $15.00 / Kg/Bag
- 99.8%
- Wuhan Dujiang Industrial Co., Ltd.
-
- 3-Fluoro-6-nitro-o-xylene
1736-87-4
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd