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Floxuridine

Floxuridine
Floxuridine structure
CAS No.
50-91-9
Chemical Name:
Floxuridine
Synonyms
FUD;FUDR;FDUR;5-FDU;FDURD;5-FUDR;2'-DFUR;nsc27640;ro5-0360;Nsc 27640
CBNumber:
CB3210097
Molecular Formula:
C9H11FN2O5
Formula Weight:
246.19
MOL File:
50-91-9.mol

Floxuridine Properties

Melting point:
148 °C(lit.)
alpha 
35.9 º (c=1, water)
Boiling point:
150 °C
Density 
1.3751 (estimate)
storage temp. 
2-8°C
form 
Powder
pka
pKa 7.44 (Uncertain)
color 
White to almost white
Water Solubility 
soluble
Merck 
14,4112
BRN 
2645818
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
ODKNJVUHOIMIIZ-GFCOJPQKSA-N
CAS DataBase Reference
50-91-9(CAS DataBase Reference)
FDA UNII
039LU44I5M
NCI Dictionary of Cancer Terms
floxuridine
NIST Chemistry Reference
Uridine, 2'-deoxy-5-fluoro-(50-91-9)
EPA Substance Registry System
Floxuridine (50-91-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H341-H360-H301
Precautionary statements  P264-P270-P301+P310+P330-P405-P501-P201-P280-P301+P312a-P308+P313-P501a
Hazard Codes  Xn,T,Xi
Risk Statements  22-68-36/37/38-40-20/21/22
Safety Statements  22-36-36/37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  YU7525000
10-23
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29349990
Toxicity LD50 oral in rat: 215mg/kg

Floxuridine price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 343333 5-Fluoro-2?-deoxyuridine 50-91-9 50mg $119 2019-12-02 Buy
Sigma-Aldrich 1271008 Floxuridine United States Pharmacopeia (USP) Reference Standard 50-91-9 250mg $352.8 2019-12-02 Buy
TCI Chemical D2235 2'-Deoxy-5-fluorouridine >98.0%(HPLC)(T) 50-91-9 1g $329 2020-06-24 Buy
TCI Chemical D2235 2'-Deoxy-5-fluorouridine >98.0%(HPLC)(T) 50-91-9 100mg $61 2020-06-24 Buy
Alfa Aesar L16497 5-Fluoro-2'-deoxyuridine, 98+% 50-91-9 100mg $89 2020-06-24 Buy

Floxuridine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Antiviral; antineoplastic.

Uses

renal function diagnosis

Uses

Floxuridine USP is used in Palliative treatment of gastrointestinal adenocarcinoma with liver metastases.

Definition

ChEBI: A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

brand name

Fudr (Mayne).

General Description

Inhibits DNA synthesis.

General Description

The drug is available as a 500-mg vial of lyophilized powder.The drug is used to treat metastatic GI adenocarcinoma.The mechanism of action of this fluoropyrimidine deoxynucleosideanalog involves metabolic conversion to 5-fluorouracil(5-FU) metabolites resulting in inhibition of TSthus disrupting DNA synthesis, function, and repair.Resistance can occur because of increased expression of TS,decreased levels of reduced folate 5,10-methylenetetrahydrofolate,increased activity of DNA repair enzymes, and increasedexpression of dihydropyrimidine dehydrogenase(the major catabolic enzyme). The drug is poorly absorbedfrom the GI tract and is extensive metabolized to 5-FU and5-FU metabolites. Dihydropyrimidine dehydrogenase is themain enzyme responsible for 5-FU catabolism, and it ispresent in liver, GI mucosa, white blood cells, and kidney.The drug interaction and toxicity profiles are equivalent tothose of 5-FU.

Health Hazard

ACUTE/CHRONIC HAZARDS: Floxuridine is highly toxic by ingestion.

Fire Hazard

Flash point data for Floxuridine are not available, but Floxuridine is probably combustible.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: hypermotitity, diarrhea, nausea, vomiting and other gastrointestinal effects, allergic dermatitis, and bone marrow changes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Fand NOx.

Floxuridine Preparation Products And Raw materials

Raw materials

Preparation Products


Floxuridine Suppliers

Global( 304)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Ribio Biotech Co.,Ltd
010-62664360
yinxc@ribio.com.cn CHINA 117 58
Nanjing Baifuli Technology Co., Ltd.
+86-15335185688
sales@unisyn.cn CHINA 332 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Jinan Carbotang Biotech Co.,Ltd.
+86 15866703830
figo.gao@foxmail.com CHINA 1147 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Yunbio Tech Co.,Ltd.
010-60605551
010-60605551 yunbiochem@126.com CHINA 258 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58

View Lastest Price from Floxuridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 Floxuridine
50-91-9
US $0.00-0.00 / 公斤 1KG 99.0%+ 800 tons Shaanxi Dideu Medichem Co. Ltd
2018-12-23 Floxuridine
50-91-9
US $8.00 / kg 1kg 99% 10tons career henan chemical co

Floxuridine Spectrum


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