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Oxatomide

Oxatomide
Oxatomide structure
CAS No.
60607-34-3
Chemical Name:
Oxatomide
Synonyms
Tinse;Truxa;tinset;r35443;Dasten;Cobiona;Celtect;kw-4354;Cenacert;Fensedyl
CBNumber:
CB3210840
Molecular Formula:
C27H30N4O
Formula Weight:
426.55
MOL File:
60607-34-3.mol

Oxatomide Properties

Melting point:
153.60C
Boiling point:
541.98°C (rough estimate)
Density 
1.1239 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO: soluble
form 
White solid.
pka
12.20±0.30(Predicted)
color 
white
CAS DataBase Reference
60607-34-3(CAS DataBase Reference)
FDA UNII
J31IL9Z2EE
ATC code
R06AE06
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DE2276000
Toxicity LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards)

Oxatomide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O9387 Oxatomide ≥99% 60607-34-3 10mg $272 2021-03-22 Buy

Oxatomide Chemical Properties,Uses,Production

Chemical Properties

White Powder

Originator

Tinset,Janssen,W. Germany ,1981

Uses

Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action

Uses

Inhibits the release and actions of leukotrienes

Manufacturing Process

A mixture of 53 parts of 1-(3chloropropyl)-2H-benzimidazol-2one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium bicarbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with waterseparator. After cooling, water is added and the layers are separated. The 4methyl-2pentanone phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol. The product is filtered off and dried, yielding 1-[3-[4-(diphenylmethyl)-1piperazinyl]propyl]-2H-benzimidazole-2-one; melting point 153.6°C.

Therapeutic Function

Antiallergic

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx.

Oxatomide Preparation Products And Raw materials

Raw materials

Preparation Products


Oxatomide Suppliers

Global( 86)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32439 55
Chemwill Asia Co.,Ltd. 86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23975 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1938 70

View Lastest Price from Oxatomide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Oxatomide
60607-34-3
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-17 Oxatomide USP/EP/BP
60607-34-3
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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