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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Structure
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate structure
CAS No.
143557-91-9
Chemical Name:
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Synonyms
N-Boc-Nortropine;N-Boc-Desmethyltropine;N-tert-Butoxycarbonylnortropan-3-ol;8-(tert-Butoxycarbonyl)-3-alpha-nortropanol;endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;(3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CBNumber:
CB32129362
Molecular Formula:
C12H21NO3
Molecular Weight:
227.3
MDL Number:
MFCD22409620
MOL File:
143557-91-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:43
Product description Number Pack Size Price
tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 97% OR950059 1g $15
endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane 4H56-1-LH 1g $24
tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 97% OR950059 5g $40
endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane 4H56-1-LH 5G $64
tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate FB140344 2g $80
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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Properties

Melting point 141.5℃
Boiling point 328℃
Density 1.146
Flash point 152℃
storage temp. 2-8°C
pka 14.79±0.20(Predicted)
Appearance White to off-white Solid
InChI InChI=1/C12H21NO3/c1-12(2,3)16-11(15)13-8-4-5-9(13)7-10(14)6-8/h8-10,14H,4-7H2,1-3H3/t8-,9?,10+/s3
InChIKey SEGZJJSZYOEABC-RHMQUPMUNA-N
SMILES C(=O)(OC(C)(C)C)N1[C@H]2CCC1C[C@H](O)C2 |&1:8,13,r|

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Risk Statements  22-36/37/38
Safety Statements  22-26-36/37/39
RIDADR  UN2811
HS Code  2933399990
NFPA 704
1
2 0

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR950059 tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 97% 143557-91-9 1g $15 2021-12-16 Buy
SynQuest Laboratories 4H56-1-LH endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane 143557-91-9 1g $24 2021-12-16 Buy
Apolloscientific OR950059 tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 97% 143557-91-9 5g $40 2021-12-16 Buy
SynQuest Laboratories 4H56-1-LH endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane 143557-91-9 5G $64 2021-12-16 Buy
Biosynth Carbosynth FB140344 tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 143557-91-9 2g $80 2021-12-16 Buy
Product number Packaging Price Buy
OR950059 1g $15 Buy
4H56-1-LH 1g $24 Buy
OR950059 5g $40 Buy
4H56-1-LH 5G $64 Buy
FB140344 2g $80 Buy

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical Properties,Uses,Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

Nortropine

538-09-0

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

143557-91-9

General procedure for the synthesis of tert-butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate from di-tert-butyl dicarbonate and endo-8-azabicyclo[3.2.1]octan-3-ol: endo-8-azabicyclo[3.2.1]octan-3-ol (3.6 g, 28.3 mmol) was dissolved in dichloromethane (50 mL) and the solution was cooled to 0°C. Triethylamine (7.8 mL, 56.7 mmol) and di-tert-butyl dicarbonate (7.4 g, 33.9 mmol) were added sequentially with stirring. The reaction mixture was gradually warmed to room temperature and stirring was continued for 12 hours. After completion of the reaction, the reaction mixture was diluted with distilled water. The organic layer was separated and washed sequentially with saturated aqueous citric acid solution, distilled water and saturated saline. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford tert-butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate as a white solid (6.45 g, 28.4 mmol, 100% yield). Mass spectrum (ESI) m/z: 228 [M + H]+.

References

[1] Patent: WO2007/63071, 2007, A1. Location in patent: Page/Page column 15
[2] Patent: US2007/123525, 2007, A1. Location in patent: Page/Page column 20
[3] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 210; 211
[4] Patent: WO2014/152144, 2014, A1. Location in patent: Paragraph 0190
[5] Patent: WO2009/106534, 2009, A1. Location in patent: Page/Page column 73

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Preparation Products And Raw materials

Raw materials

8-Azabicyclo[3.2.1]octan-3-ol, 8-[(4-fluorophenyl)methyl]- N-Boc-Nortropinone Di-tert-butyl dicarbonate 8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-(benzoyloxy)-, 1,1-dimethylethyl ester, (3-endo)- Nortropine
Carbonic acid, bis(1,1-dimethylethyl) ester Dichloromethane Triethylamine

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Preparation Products

N-Boc-exo-3-aminotropane

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Suppliers

Global( 107)Suppliers
Supplier Tel Email Country ProdList Advantage
Accela ChemBio Inc.
+1-858-6993322 info@accelachem.com United States 21193 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29845 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88299272 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Shanghai Rlavie Technology Co ltd 		+86-021-67759270 +8617717059219 sales@rlavie.com China 1030 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Supplier Advantage
Accela ChemBio Inc.
58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Shanghai Rlavie Technology Co ltd 		58
Career Henan Chemica Co 		58

View Lastest Price from tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Boc-Nortropine pictures 2022-04-22 N-Boc-Nortropine
143557-91-9
 US $0.00-0.00 / kg 0.001kg 98%min 100kgs/month Shanghai Rlavie Technology Co ltd
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate pictures 2019-07-10 tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
143557-91-9
 US $1.00 / KG 1KG 98% 150KG Career Henan Chemical Co
  • N-Boc-Nortropine pictures
  • N-Boc-Nortropine
    143557-91-9
  • US $0.00-0.00 / kg
  • 98%min
  • Shanghai Rlavie Technology Co ltd

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Spectrum

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(143557-91-9)1HNMR

143557-91-9(tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate)Related Search:

Nortropine hydrochloride Nortropine GRANISETRON IMPURITY B tert-butyl endo-3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate N-BOC-INDOLINE-7-CARBOXYLIC ACID
N-T-BOC-PYRROLE MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 1-BOC-2,3-DIHYDRO-7-INDOLECARBALDEHYDE TERT-BUTYL FORMATE tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate N-Boc-Nortropine endo-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid 1,1-dimethylethyl ester N-tert-Butoxycarbonylnortropan-3-ol endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester tert-butyl (1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane (3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane 8-Azabicyclo[3.2.1]octane-8-carboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (3-endo)- rel-tert-butyl (1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate tert-butyl endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate N-Boc-Desmethyltropine 8-(tert-Butoxycarbonyl)-3-alpha-nortropanol tert-butyl Rel-(1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 143557-91-9