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beta-Hydroxyisovaleric Acid

beta-Hydroxyisovaleric Acid
beta-Hydroxyisovaleric Acid structure
CAS No.
625-08-1
Chemical Name:
beta-Hydroxyisovaleric Acid
Synonyms
RARECHEM AL BO 2324;HYDROXY-METHYLBUTYRATE;3-B-HYDROXYBUTYRIC ACID;?Hydroxyisovaleric acid;3-Hydroxyisovaleric acid;SS-HYDROXYISOVALERIC ACID;BETA-HYDROXYISOVALERIC ACID;(S)-2-Hydroxyisovaleric Acid;HYDROXYISOVALERIC ACID, BETA-;β-Hydroxy-β-MethylButyric acid
CBNumber:
CB3213104
Molecular Formula:
C5H10O3
Formula Weight:
118.13
MOL File:
625-08-1.mol

beta-Hydroxyisovaleric Acid Properties

Melting point:
−80 °C(lit.)
Boiling point:
88 °C1 mm Hg(lit.)
Density 
0.938 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4415(lit.)
Flash point:
113 °C
storage temp. 
Refrigerator
form 
Liquid
Specific Gravity
1.10
color 
Pale yellow
Water Solubility 
Soluble in water and ethanol.
BRN 
1743952
InChIKey
AXFYFNCPONWUHW-UHFFFAOYSA-N
CAS DataBase Reference
625-08-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN 3334
WGK Germany  3
10-13-21
HS Code  29181990

beta-Hydroxyisovaleric Acid price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 55453 β-Hydroxyisovaleric acid ≥95.0% (T) 625-08-1 1g $437 2018-11-13 Buy
TCI Chemical H0701 β-Hydroxyisovaleric Acid >96.0%(GC)(T) 625-08-1 5g $95 2018-11-22 Buy
TCI Chemical H0701 β-Hydroxyisovaleric Acid >96.0%(GC)(T) 625-08-1 25g $322 2018-11-22 Buy
Alfa Aesar 042722 3-Hydroxy-3-methylbutyric acid, 96% 625-08-1 10g $30.7 2018-11-16 Buy
Alfa Aesar 042722 3-Hydroxy-3-methylbutyric acid, 96% 625-08-1 1kg $1130 2018-11-16 Buy

beta-Hydroxyisovaleric Acid Chemical Properties,Uses,Production

Description

β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β- methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. It plays a part in protein synthesis and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs, and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as a calcium salt.
Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMB' s proposed mechanisms of action the following:
Increased sarcolemmal integrity via conversion to HMG-CoA
Enhanced protein synthesis via the mTOR pathway
Depression of protein degradation through inhibition of the ubiquitin pathway
Three grams of Calcium beta-hydroxy-beta-methylbutyrate per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with chronic obstructive pulmonary disease in hospital intensive care units, muscle wasting associated with HIV or AIDS and with cancer, and trauma victims with severe injuries.
The human body produces about 0.2 - 0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses.

Chemical Properties

colorless to light yellow liquid

Uses

β-Hydroxyisovaleric Acid is a metabolite of the essential amino acid Leucine and is synthesized in the human body. Studies suggest that β-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated β-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency.

Definition

ChEBI: A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.

beta-Hydroxyisovaleric Acid Preparation Products And Raw materials

Raw materials

Preparation Products


beta-Hydroxyisovaleric Acid Suppliers

Global( 81)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21672 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
sales@nbinno.com CHINA 925 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Nanjing Daqin Pharmaceutical Technology Co., Ltd. +86 025-58470199 18351831988
+86 025-58470199 sales@daqinpharma.com CHINA 155 58

View Lastest Price from beta-Hydroxyisovaleric Acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 BETA-HYDROXYISOVALERIC ACID
625-08-1
US $1.00 / KG 1KG 98% 100KG career henan chemical co

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