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Guaiacol

Chemical properties Application Preparative methods Toxicity
Guaiacol
Guaiacol structure
CAS No.
90-05-1
Chemical Name:
Guaiacol
Synonyms
Guajol;Guasol;guiacol;nsc3815;Guaiaco;GAIACOL;Anastil;Guaicol;uaiacoL;GUAIACOL
CBNumber:
CB3214914
Molecular Formula:
C7H8O2
Formula Weight:
124.14
MOL File:
90-05-1.mol

Guaiacol Properties

Melting point:
26-29 °C (lit.)
Boiling point:
205 °C (lit.)
Density 
1.129 g/mL at 25 °C (lit.)
vapor density 
4.27 (vs air)
vapor pressure 
0.11 mm Hg ( 25 °C)
refractive index 
n20/D 1.543(lit.)
FEMA 
2532 | GUAIACOL
Flash point:
180 °F
storage temp. 
2-8°C
solubility 
H2O: insoluble
form 
Liquid After Melting
pka
9.98(at 25℃)
color 
Clear colorless to light yellow
PH
5.4 (10g/l, H2O, 20℃)
Odor Threshold
0.0074ppm
Water Solubility 
17 g/L (15 ºC)
FreezingPoint 
28℃
Sensitive 
Air Sensitive
Merck 
14,4553
JECFA Number
713
BRN 
508112
Stability:
Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey
LHGVFZTZFXWLCP-UHFFFAOYSA-N
CAS DataBase Reference
90-05-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
GUAIACOL
EWG's Food Scores
1-2
FDA UNII
6JKA7MAH9C
NIST Chemistry Reference
Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System
Guaiacol (90-05-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P280-P301+P312+P330-P305+P351+P338-P337+P313
Hazard Codes  Xn,T,Xi
Risk Statements  22-36/38
Safety Statements  26
RIDADR  2810
WGK Germany  1
RTECS  SL7525000
Autoignition Temperature 750 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  II
HS Code  29095010
Toxicity LD50 orally in rats: 725 mg/kg (Taylor)

Guaiacol price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18339 2-Methoxyphenol for synthesis 90-05-1 5 mL $26.27 2021-03-22 Buy
Sigma-Aldrich 8.18339 2-Methoxyphenol for synthesis 90-05-1 250 mL $55.87 2021-03-22 Buy
Sigma-Aldrich W253200 Guaiacol natural, ≥99%, FG 90-05-1 1 kg $105 2021-03-22 Buy
Sigma-Aldrich CRM40484 Guaiacol solution certified reference material, 2000?μg/mL in methanol, ampule of 1?mL 90-05-1 1 mL $128 2021-03-22 Buy
Sigma-Aldrich 8.18339 2-Methoxyphenol for synthesis 90-05-1 1 L $172.97 2021-03-22 Buy

Guaiacol Chemical Properties,Uses,Production

Chemical properties

It appears as white or slightly yellow crystals or colorless to pale yellow transparent oily liquid. It has a special aromatic smell. It is slightly soluble in water and benzene. It is easily soluble in glycerol. It is miscible with ethanol, ether, chloroform, oil and glacier acetic acid.

Application

Used for pharmaceuticals, dyes and spices intermediates
Mainly used for the preparation of coffee, vanilla, fumigation and tobacco flavor.
Used for the synthesis of dyes, also used as analytical reagents
In medicine, it can be used for the manufacture of calcium guaiacol sulfonate; in the spice industry, it is used the manufacture of vanillin and artificial musk; Used for test copper, hydrocyanic acid and nitrite

Preparative methods

It can be obtained by diazotization and hydrolysis of anthranium anisole.
Obtained from fractionated of wood oil.
In the nature of guaiacol is presented in the guaiacum or pine oil. In the creosote oil obtained from wood dry distillation, guaiacol is the major ingredient. This product could be obtained through fractional distillation of creosote oil. Japan Osaka Refining Company takes o-nitrochlorobenzene as raw material, first synthesizes o-nitroanisole, and then reduces it to o-anisidine, and finally obtains the goods. China's production method is roughly the same. Ingredient consumption quota: 1250 kg / t of amino-containing anisole, 1500 kg / t of sulfuric acid (93%), 700 kg / t of sodium nitrite and 400 kg / t of copper sulfate.

Toxicity

LD50:900 mg / kg (rat, subcutaneous).
LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.

Description

Guaiacol has a characteristic sweet odor. It is slightly phenolic. Guaiacol is obtained from hardwood tar or synthetically from onitrophenol via o-anisidine.

Chemical Properties

Guaiacol has a characteristic sweet odor. It is slightly phenolic.

Chemical Properties

Light Yellow Oil

Occurrence

Detected in the distillation product from guaiac resin; guaiacol is found in castoreum oil, in the essential oil from fowers of Pandanus odoratissimus L , in the distillation waters of orange leaves, in the essential oil of Ruta Montana L and in the essential oil of tobacco leaves Also reported found in lemon peel oil, bog blueberry, asparagus, cabbage, celery, onion, chive, tomato, peppermint oil, rye bread, Parmesan cheese, butter, smoked fsh, meats, barley, dried bonito, malt, hardwood smoke, cognac, beer, brandy, rum, whiskies, sherry, grape wines, cocoa, coffee, tea, peanuts, popcorn, soybeans, avocado, beans, mushroom, sesame seed, mango, tamarind, rice dill, licorice, corn oil, cuttlefsh and other sources

Uses

Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.

Uses

Synthetic flavors, medicine (expectorant).

Uses

A phenolic natural product and reducing co-substrate for COX reactions.

Definition

ChEBI: A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.

Aroma threshold values

Detection: 3 to 31 ppb; aroma characteristics at 1.0%: phenolic, smoky, spicy, medicinal, vanilla, savory meaty, woody with a bourbon whiskey casky nuance.

Taste threshold values

Taste characteristics at 2.0 ppm: woody, phenolic, bacon, savory, smoky and medicinal.

General Description

Colorless to amber crystals or liquid. Density (of solid) 1.129 g / cm3. Solidifies at 28°C (82.4°F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble . Soluble in aqueous sodium hydroxide. Used medicinally as an expectorant. Used, because of its anti-oxidant properties, as an anti-skinning agent for paints.

Air & Water Reactions

Sensitive to air and light (darkens). Slightly water soluble.

Reactivity Profile

Guaiacol may react with oxidizing materials. Guaiacol forms salts readily with bases.

Hazard

Toxic by ingestion and skin absorption.

Fire Hazard

Guaiacol is combustible.

Chemical Synthesis

Obtained from hardwood tar or synthetically from o-nitrophenol via o-anisidine.

Purification Methods

Crystallise guaiacol from *benzene/pet ether or distil it in a vacuum. [Beilstein 6 H 768, 6 IV 5563.]

Guaiacol Preparation Products And Raw materials

Raw materials

Preparation Products


Guaiacol Suppliers

Global( 589)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20892 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58

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View Lastest Price from Guaiacol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-08 Guaiacol
90-05-1
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-01 Guaiacol
90-05-1
US $10.00 / KG 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-15 Guaiacol
90-05-1
US $1.60 / g 1KG 99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd

Guaiacol Spectrum


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