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Guaiacol

Chemical properties Application Preparative methods Toxicity
Guaiacol
Guaiacol structure
CAS No.
90-05-1
Chemical Name:
Guaiacol
Synonyms
Guajol;Guasol;guiacol;nsc3815;Guaiaco;uaiacoL;Anastil;Guaicol;GAIACOL;GUAIACOL
CBNumber:
CB3214914
Molecular Formula:
C7H8O2
Formula Weight:
124.14
MOL File:
90-05-1.mol

Guaiacol Properties

Melting point:
26-29 °C(lit.)
Boiling point:
205 °C(lit.)
Density 
1.129 g/mL at 25 °C(lit.)
vapor density 
4.27 (vs air)
vapor pressure 
0.11 mm Hg ( 25 °C)
refractive index 
n20/D 1.543(lit.)
FEMA 
2532 | GUAIACOL
Flash point:
180 °F
storage temp. 
Refrigerator
solubility 
H2O: insoluble
pka
9.98(at 25℃)
form 
Liquid After Melting
color 
Clear colorless to light yellow
PH
5.4 (10g/l, H2O, 20℃)
Odor Threshold
0.0074ppm
Water Solubility 
17 g/L (15 ºC)
FreezingPoint 
28℃
Sensitive 
Air Sensitive
JECFA Number
713
Merck 
14,4553
BRN 
508112
Stability:
Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey
LHGVFZTZFXWLCP-UHFFFAOYSA-N
CAS DataBase Reference
90-05-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
GUAIACOL
EWG's Food Scores
1-2
FDA UNII
6JKA7MAH9C
NIST Chemistry Reference
Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System
Guaiacol (90-05-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P280-P301+P312+P330-P305+P351+P338-P337+P313
Hazard Codes  Xn,T,Xi
Risk Statements  22-36/38
Safety Statements  26
RIDADR  2810
WGK Germany  1
RTECS  SL7525000
Autoignition Temperature 750 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  II
HS Code  29095010
Toxicity LD50 orally in rats: 725 mg/kg (Taylor)

Guaiacol price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G5502 Guaiacol oxidation indicator 90-05-1 1kg $204 2019-12-02 Buy
Sigma-Aldrich 1300004 Guaiacol United States Pharmacopeia (USP) Reference Standard 90-05-1 1g $352.8 2019-12-02 Buy
TCI Chemical M0121 Guaiacol >98.0%(GC) 90-05-1 25g $13 2019-12-02 Buy
TCI Chemical M0121 Guaiacol >98.0%(GC) 90-05-1 500g $46 2019-12-02 Buy
Alfa Aesar A16319 2-Methoxyphenol, 98+% 90-05-1 250g $35 2019-12-02 Buy

Guaiacol Chemical Properties,Uses,Production

Chemical properties

It appears as white or slightly yellow crystals or colorless to pale yellow transparent oily liquid. It has a special aromatic smell. It is slightly soluble in water and benzene. It is easily soluble in glycerol. It is miscible with ethanol, ether, chloroform, oil and glacier acetic acid.

Application

Used for pharmaceuticals, dyes and spices intermediates
Mainly used for the preparation of coffee, vanilla, fumigation and tobacco flavor.
Used for the synthesis of dyes, also used as analytical reagents
In medicine, it can be used for the manufacture of calcium guaiacol sulfonate; in the spice industry, it is used the manufacture of vanillin and artificial musk; Used for test copper, hydrocyanic acid and nitrite

Preparative methods

It can be obtained by diazotization and hydrolysis of anthranium anisole.
Obtained from fractionated of wood oil.
In the nature of guaiacol is presented in the guaiacum or pine oil. In the creosote oil obtained from wood dry distillation, guaiacol is the major ingredient. This product could be obtained through fractional distillation of creosote oil. Japan Osaka Refining Company takes o-nitrochlorobenzene as raw material, first synthesizes o-nitroanisole, and then reduces it to o-anisidine, and finally obtains the goods. China's production method is roughly the same. Ingredient consumption quota: 1250 kg / t of amino-containing anisole, 1500 kg / t of sulfuric acid (93%), 700 kg / t of sodium nitrite and 400 kg / t of copper sulfate.

Toxicity

LD50:900 mg / kg (rat, subcutaneous).
LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.

Description

Guaiacol has a characteristic sweet odor. It is slightly phenolic. Guaiacol is obtained from hardwood tar or synthetically from onitrophenol via o-anisidine.

Chemical Properties

Guaiacol has a characteristic sweet odor. It is slightly phenolic.

Chemical Properties

Light Yellow Oil

Occurrence

Detected in the distillation product from guaiac resin; guaiacol is found in castoreum oil, in the essential oil from fowers of Pandanus odoratissimus L , in the distillation waters of orange leaves, in the essential oil of Ruta Montana L and in the essential oil of tobacco leaves Also reported found in lemon peel oil, bog blueberry, asparagus, cabbage, celery, onion, chive, tomato, peppermint oil, rye bread, Parmesan cheese, butter, smoked fsh, meats, barley, dried bonito, malt, hardwood smoke, cognac, beer, brandy, rum, whiskies, sherry, grape wines, cocoa, coffee, tea, peanuts, popcorn, soybeans, avocado, beans, mushroom, sesame seed, mango, tamarind, rice dill, licorice, corn oil, cuttlefsh and other sources

Uses

Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.

Uses

Synthetic flavors, medicine (expectorant).

Uses

A phenolic natural product and reducing co-substrate for COX reactions.

Definition

ChEBI: A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.

Aroma threshold values

Detection: 3 to 31 ppb; aroma characteristics at 1.0%: phenolic, smoky, spicy, medicinal, vanilla, savory meaty, woody with a bourbon whiskey casky nuance.

Taste threshold values

Taste characteristics at 2.0 ppm: woody, phenolic, bacon, savory, smoky and medicinal.

General Description

Colorless to amber crystals or liquid. Density (of solid) 1.129 g / cm3. Solidifies at 28°C (82.4°F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble . Soluble in aqueous sodium hydroxide. Used medicinally as an expectorant. Used, because of its anti-oxidant properties, as an anti-skinning agent for paints.

Air & Water Reactions

Sensitive to air and light (darkens). Slightly water soluble.

Reactivity Profile

Guaiacol may react with oxidizing materials. Guaiacol forms salts readily with bases.

Hazard

Toxic by ingestion and skin absorption.

Fire Hazard

Guaiacol is combustible.

Chemical Synthesis

Obtained from hardwood tar or synthetically from o-nitrophenol via o-anisidine.

Purification Methods

Crystallise guaiacol from *benzene/pet ether or distil it in a vacuum. [Beilstein 6 H 768, 6 IV 5563.]

Guaiacol Preparation Products And Raw materials

Raw materials

Preparation Products


Guaiacol Suppliers

Global( 439)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19927 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2674 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2382 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28235 58

Related articles


View Lastest Price from Guaiacol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-07 Guaiacol
90-05-1
US $2.00 / KG 1KG 99%MIN 100MT Henan Xiangtong Chemical Co., Ltd.
2019-10-25 Guaiacol
90-05-1
US $0.00 / ml 0.1ml GC≥98% 100 ml Shanghai Standard Technology Co., Ltd.
2020-04-21 Guaiacol
90-05-1
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

Guaiacol Spectrum


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