ChemicalBook
Chinese Japanese Germany Korea

Guaiacol

Chemical properties Application Preparative methods Toxicity
Guaiacol
Guaiacol structure
CAS No.
90-05-1
Chemical Name:
Guaiacol
Synonyms
Guajol;Guasol;guiacol;nsc3815;Anastil;Guaicol;GAIACOL;Guaiaco;GUAIACOL;GUAIACUL
CBNumber:
CB3214914
Molecular Formula:
C7H8O2
Formula Weight:
124.14
MOL File:
90-05-1.mol

Guaiacol Properties

Melting point:
26-29 °C(lit.)
Boiling point:
205 °C(lit.)
Density 
1.129 g/mL at 25 °C(lit.)
vapor density 
4.27 (vs air)
vapor pressure 
0.11 mm Hg ( 25 °C)
refractive index 
n20/D 1.543(lit.)
FEMA 
2532 | GUAIACOL
Flash point:
180 °F
storage temp. 
Refrigerator
solubility 
H2O: insoluble
form 
Liquid After Melting
pka
9.98(at 25℃)
color 
Clear colorless to light yellow
PH
5.4 (10g/l, H2O, 20℃)
Water Solubility 
17 g/L (15 ºC)
FreezingPoint 
28℃
Sensitive 
Air Sensitive
Merck 
14,4553
JECFA Number
713
BRN 
508112
Stability:
Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey
LHGVFZTZFXWLCP-UHFFFAOYSA-N
CAS DataBase Reference
90-05-1(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System
Phenol, 2-methoxy-(90-05-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,Xi
Risk Statements  22-36/38
Safety Statements  26
RIDADR  2810
WGK Germany  1
RTECS  SL7525000
Autoignition Temperature 750 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  II
HS Code  29095010
Hazardous Substances Data 90-05-1(Hazardous Substances Data)
Toxicity LD50 orally in rats: 725 mg/kg (Taylor)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Guaiacol price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G5502 Guaiacol oxidation indicator 90-05-1 1kg $201 2018-11-13 Buy
Sigma-Aldrich 1300004 Guaiacol United States Pharmacopeia (USP) Reference Standard 90-05-1 1g $348 2018-11-13 Buy
TCI Chemical M0121 Guaiacol >98.0%(GC) 90-05-1 25g $13 2018-11-22 Buy
TCI Chemical M0121 Guaiacol >98.0%(GC) 90-05-1 500g $46 2018-11-22 Buy
Alfa Aesar A16319 2-Methoxyphenol, 98+% 90-05-1 250g $34 2018-11-13 Buy

Guaiacol Chemical Properties,Uses,Production

Chemical properties

It appears as white or slightly yellow crystals or colorless to pale yellow transparent oily liquid. It has a special aromatic smell. It is slightly soluble in water and benzene. It is easily soluble in glycerol. It is miscible with ethanol, ether, chloroform, oil and glacier acetic acid.

Application

Used for pharmaceuticals, dyes and spices intermediates
Mainly used for the preparation of coffee, vanilla, fumigation and tobacco flavor.
Used for the synthesis of dyes, also used as analytical reagents
In medicine, it can be used for the manufacture of calcium guaiacol sulfonate; in the spice industry, it is used the manufacture of vanillin and artificial musk; Used for test copper, hydrocyanic acid and nitrite

Preparative methods

It can be obtained by diazotization and hydrolysis of anthranium anisole.
Obtained from fractionated of wood oil.
In the nature of guaiacol is presented in the guaiacum or pine oil. In the creosote oil obtained from wood dry distillation, guaiacol is the major ingredient. This product could be obtained through fractional distillation of creosote oil. Japan Osaka Refining Company takes o-nitrochlorobenzene as raw material, first synthesizes o-nitroanisole, and then reduces it to o-anisidine, and finally obtains the goods. China's production method is roughly the same. Ingredient consumption quota: 1250 kg / t of amino-containing anisole, 1500 kg / t of sulfuric acid (93%), 700 kg / t of sodium nitrite and 400 kg / t of copper sulfate.

Toxicity

LD50:900 mg / kg (rat, subcutaneous).
LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.

Chemical Properties

Light Yellow Oil

Uses

Synthetic flavors, medicine (expectorant).

Uses

A phenolic natural product and reducing co-substrate for COX reactions.

Uses

Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.

Definition

ChEBI: A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.

General Description

Colorless to amber crystals or liquid. Density (of solid) 1.129 g / cm3. Solidifies at 28°C (82.4°F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble . Soluble in aqueous sodium hydroxide. Used medicinally as an expectorant. Used, because of its anti-oxidant properties, as an anti-skinning agent for paints.

Air & Water Reactions

Sensitive to air and light (darkens). Slightly water soluble.

Reactivity Profile

Guaiacol may react with oxidizing materials. Guaiacol forms salts readily with bases.

Hazard

Toxic by ingestion and skin absorption.

Fire Hazard

Guaiacol is combustible.

Purification Methods

Crystallise guaiacol from *benzene/pet ether or distil it in a vacuum. [Beilstein 6 H 768, 6 IV 5563.]

Guaiacol Preparation Products And Raw materials

Raw materials

Preparation Products


Guaiacol Suppliers

Global( 381)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58

View Lastest Price from Guaiacol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 Guaiacol
90-05-1
US $1.00 / KG 1KG 98% 100KG career henan chemical co

Guaiacol Spectrum


90-05-1(Guaiacol)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved