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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride structure

CAS No.: 86604-75-3

Chemical Name:: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

Synonyms: 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE;Omeprazole chloride;2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HCL;2-CHLORO METHYL-3,5-DIMETHLY-4-METHOXY PYRIDINE HCL;CMDM;TENA-006;Esomeprazole INT;Omeprazole Chloro;2-Chloromethyl-4-met;86604-75-3C9H13CL2NO

CBNumber:: CB3226946

Molecular Formula:: C9H13Cl2NO

Molecular Weight:: 222.11

MDL Number:: MFCD00277472

MOL File:: 86604-75-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:05

Product description	Number	Pack Size	Price
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 98%	535508	5g	$28.5
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 98%	535508	25g	$40
2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride >98.0%(HPLC)(T)	C2269	5g	$25
2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride >98.0%(HPLC)(T)	C2269	25g	$71
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride	C369240	50g	$255
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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Properties

Melting point	128-131 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Sparingly)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water.
InChI	InChI=1S/C9H12ClNO.ClH/c1-6-5-11-8(4-10)7(2)9(6)12-3;/h5H,4H2,1-3H3;1H
InChIKey	LCJDHJOUOJSJGS-UHFFFAOYSA-N
SMILES	C1(CCl)=NC=C(C)C(OC)=C1C.[H]Cl
CAS DataBase Reference	86604-75-3(CAS DataBase Reference)
FDA UNII	JNE3843NE3
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H317-H319-H335-H413

Precautionary statements

P261-P264-P273-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type N95 (US)

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

3261

WGK Germany

HazardClass

PackingGroup

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Chronic 4
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3

NFPA 704

	1
2		0

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	535508	2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 98%	86604-75-3	5g	$28.5	2026-04-30	Buy
Sigma-Aldrich	535508	2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 98%	86604-75-3	25g	$40	2026-04-30	Buy
TCI Chemical	C2269	2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride >98.0%(HPLC)(T)	86604-75-3	5g	$25	2026-04-30	Buy
TCI Chemical	C2269	2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride >98.0%(HPLC)(T)	86604-75-3	25g	$71	2026-04-30	Buy
TRC	C369240	2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride	86604-75-3	50g	$255	2021-12-16	Buy

Product number	Packaging	Price	Buy
535508	5g	$28.5	Buy
535508	25g	$40	Buy
C2269	5g	$25	Buy
C2269	25g	$71	Buy
C369240	50g	$255	Buy

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride is used as pharmaceutical intermediates. It is an intermediate in the production of the antiulcer agent Omeprazole.

Synthesis

3,5-Dimethyl-4-methoxy-2-pyridinemethanol

86604-78-6

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

86604-75-3

The general procedure for the synthesis of 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride from 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine was as follows: to a solution of 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine (25.1 g, 0.15 mol) in dichloromethane (400 mL) was added slowly and dropwise thionyl chloride (18.8 g, 0.158 mol) in dichloromethane (100 mL). 0.158 mol) to a solution of thionyl chloride (18.8 g, 0.158 mol) in dichloromethane (100 mL). The reaction was carried out at room temperature and under argon protection, and the titration process lasted for 30 minutes. After the dropwise addition, the reaction was continued with stirring at room temperature for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The solid residue obtained was suspended in hexane (200 mL) and the solid was collected by filtration. The solid was washed with hexane (50 mL) and subsequently dried in air to afford 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride 33.3 g (100% yield) as a white solid.

References

[1] Patent: WO2004/9583, 2004, A2. Location in patent: Page 156
[2] Patent: US2005/38076, 2005, A1. Location in patent: Page/Page column 6
[3] Patent: CN107011252, 2017, A. Location in patent: Paragraph 0063; 0064; 0066; 0068; 0072; 0074
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 11, p. 1777 - 1788
[5] Patent: US5292886, 1994, A

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride synthesis

Synthesis of 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride from 3,5-Dimethyl-4-methoxy-2-pyridinemethanol

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Preparation Products And Raw materials

Raw materials

2,3,5-Collidine 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE 2-(Chloromethyl)-3,5-dimethyl-4-methoxypyridine 4-Methoxy-3,5-diMethylpicolinonitrile 2-(ACETOXYMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE

4-Methoxy-2,3,5-trimethylpyride-N-oxide 2,3,5-Trimethylpyridine-1-Oxide 4-NITRO-2,3,5-TRIMETHYLPYRIDINE-N-OXIDE 3,5-DIMETHYL-4-METHOXY-2-PYRIDINE 3,5-Dimethyl-4-methoxy-2-pyridinemethanol

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Preparation Products

2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide BIIB-021 (4-methoxy-3,5-dimethylpyridin-2-yl)methanamine Ufiprazole

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Suppliers

Global( 635)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
Zhejiang Karry Pharmachem Co., Ltd.	+8613567161161	info@karrypharma.com	China	34	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58

Supplier	Advantage
Coresyn Pharmatech Co., Ltd.	58
Zhejiang Karry Pharmachem Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58

View Lastest Price from 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-30	2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3	US $0.00 / Kg/Drum	1KG	98%min	10 tons	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-12	Omeprazole Impurity J 86604-75-3	US $0.00-0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD
2025-11-18	2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
86604-75-3
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Omeprazole Impurity J
86604-75-3
US $0.00-0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
86604-75-3
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Spectrum

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride(86604-75-3)IR

86604-75-3(2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride)Related Search:

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CMDM Omeprazole intermediate Omeprazole EP Impurity XI 2-(chloromethyl)-4-methoxy-3,5-dimethyl-pyridine dyhydrochloride 2-chloro-methyl-3,5-dimethyl-4-methoxy pyridine hcl (omeprazole-chloro compound) 2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HYDROCHLORIDE 2-CHLOROMETHYL-4-METHOXY-3,5-DIMETHYL PYRIDINE HCL 2-(CHLOROMETHYL)-4-METHOXY-3,5-LUTIDINE HCL 2-CHLOROMETHYL-4-METHOXY-3,5-LUTIDINE HYDROCHLORIDE 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYL-PYRIDINEHYDROCHLORIDE(INTERMEDIATEOFOMEPRAXOLE) 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYL-PYRIDINE HDYROCHLORIDE 2-CHLOROMETHYL-4-METHOXY-3,5-DIMETHYLPYRIDINE HCLOMEPRAZOLE 2-Chloromethyl-4-met (S)-Omeprazole Intermediate 1 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine hydrochloride 98% 2-ChloroMethyl-3,5-diMethyl-4-Methoxy pyridine hydrochlorid Omeprazole chloride compound 2-Chloromethyl-4-methoxy-3,5-dimethylpyridinehydrochloride,98% 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine hydr OMeprazole chloro interMediate Pyridine,2-(chloroMethyl)-4-Methoxy-3,5-diMethyl-, hydrochloride (1:1) EsoMeprazo interMediate A Omeprazole Related Compound 13 Omeprazole Impurity W Omeprazole Impurity 9 Omeprazole Related Compound 13 HCl TENA-006 86604-75-3C9H13CL2NO 3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride Esomeprazole Sodium Impurity 42 2-Chloromethyl-3,5-dimethyl Pyridine,2-(chloromethyl)-4-methoxy-3,5-dimethyl Omeprazole related substances 13 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride > 2-CHLOROMETHYL- 3,5-DIMETHYL - 4 - METHOXY PYRIDINE HYDROCHLORIDE (OMEPRAZOLE CHLORO COMPOUND) )-4-methoxy-3,5-dimethyL 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride ISO 9001：2015 REACH 2-Chloromethyl-4-methoxy -3,5-dimethylpyridine hydrochloride (Ome Chloro) 2-Chloromethyl-3,5-dimethyl-4-Methoxy pyridine Hydrochloride (Omeprazole Chloro) Omeprazole Chloro Impurity 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCLQ: What is 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What is the CAS Number of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What is the storage condition of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What are the applications of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE 2-CHLORO METHYL-3,5-DIMETHLY-4-METHOXY PYRIDINE HCL Esomeprazole INT Esomeprazole Impurity 107 2-chloromethyl-3 5-dimethyl-4-methoxy pyridine hydrochloride (Omechloro) Omeprazole Chloro 2-Chloromethyl-3,5-Dimethyl-4-Methoxy Pyridine Hydroc 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE (OMEPRAZOLE CHLORO) 2-Chloromethyl-4-Methoxy-3,5-Dimethylpyridine Hydrochl Omeprazole EP Impurity XI 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl (Ome Chloro) 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride (Chloropyridine) 2-(Chloromethyl)-3,5-dimethoxypyridinehydrochloride 2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HCL Omeprazole chloride 86604-75-3 8660-75-3