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Citric acid monohydrate

Citric acid monohydrate
Citric acid monohydrate
CAS No.
5949-29-1
Chemical Name:
Citric acid monohydrate
Synonyms
citric;ACETONUM;PROPANONE;FEMA 3326;ACETONE D;ACETONE 300;EXTRAN AP 22;ACETONE 5000;METHYL KETONE;TACUSSEL TE100
CBNumber:
CB3235573
Molecular Formula:
C6H10O8
Formula Weight:
210.1388
MOL File:
5949-29-1.mol

Citric acid monohydrate Properties

Melting point:
-94 °C(lit.)
Boiling point:
56 °C760 mm Hg(lit.)
Density 
0.791 g/mL at 25 °C(lit.)
vapor density 
2 (vs air)
vapor pressure 
184 mm Hg ( 20 °C)
refractive index 
n20/D 1.359(lit.)
Flash point:
1 °F
storage temp. 
Store at RT.
solubility 
H2O: soluble54% (w/w) at 10°C (Citric acid in water)
form 
Solid
color 
White
Specific Gravity
0.810 (20/4℃)
PH
1.85 (50g/l, H2O, 25℃)
Water Solubility 
1630 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,2326
BRN 
4018641
Stability:
Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates.
InChIKey
YASYEJJMZJALEJ-UHFFFAOYSA-N
CAS DataBase Reference
5949-29-1(CAS DataBase Reference)
NIST Chemistry Reference
Citric acid monohydrate(5949-29-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xi
Risk Statements  11-36-66-67-41-36/37/38-37/38
Safety Statements  9-16-26-37/39-36/37/39-36
RIDADR  UN 1090 3/PG 2
WGK Germany  1
RTECS  AL3150000
TSCA  Yes
HS Code  29181400
Toxicity LD50 orally in Rabbit: 3000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Citric acid monohydrate price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0706 Citric acid monohydrate BioXtra, ≥99.5% 5949-29-1 500g $96.8 2018-11-13 Buy
Sigma-Aldrich C0706 Citric acid monohydrate BioXtra, ≥99.5% 5949-29-1 1kg $180 2018-11-13 Buy
Alfa Aesar 022869 Citric acid monohydrate, 99.5+% 5949-29-1 1kg $89.9 2018-11-16 Buy
Alfa Aesar 022869 Citric acid monohydrate, 99.5+% 5949-29-1 100g $24.8 2018-11-16 Buy
Sigma-Aldrich C7129 Citric acid monohydrate reagent grade, ≥98% (GC/titration) 5949-29-1 100g $26.7 2018-11-20 Buy

Citric acid monohydrate Chemical Properties,Uses,Production

Chemical Properties

white crystals or powder

Chemical Properties

Citric acid monohydrate occurs as colorless or translucent crystals, or as a white crystalline, efflorescent powder. It is odorless and has a strong acidic taste. The crystal structure is orthorhombic.

Production Methods

Citric acid occurs naturally in a number of plant species and may be extracted from lemon juice, which contains 5–8% citric acid, or pineapple waste. Anhydrous citric acid may also be produced industrially by mycological fermentation of crude sugar solutions such as molasses, using strains of Aspergillus niger . Citric acid is purified by recrystallization; the anhydrous form is obtained from a hot concentrated aqueous solution and the monohydrate from a cold concentrated aqueous solution.

Pharmaceutical Applications

Citric acid (as either the monohydrate or anhydrous material) is widely used in pharmaceutical formulations and food products, primarily to adjust the pH of solutions. It has also been used experimentally to adjust the pH of tablet matrices in enteric-coated formulations for colon-specific drug delivery. Citric acid monohydrate is used in the preparation of effervescent granules, while anhydrous citric acid is widely used in the preparation of effervescent tablets. Citric acid has also been shown to improve the stability of spray-dried insulin powder in inhalation formulations.
In food products, citric acid is used as a flavor enhancer for its tart, acidic taste. Citric acid monohydrate is used as a sequestering agent and antioxidant synergist. It is also a component of anticoagulant citrate solutions. Therapeutically, preparations containing citric acid have been used to dissolve renal calculi.

Safety

Citric acid is found naturally in the body, mainly in the bones, and is commonly consumed as part of a normal diet. Orally ingested citric acid is absorbed and is generally regarded as a nontoxic material when used as an excipient. However, excessive or frequent consumption of citric acid has been associated with erosion of the teeth.
Citric acid and citrates also enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citric acid or citrate-containing products.

storage

Citric acid monohydrate loses water of crystallization in dry air or when heated to about 408℃. It is slightly deliquescent in moist air. Dilute aqueous solutions of citric acid may ferment on standing.

Purification Methods

Crystallise it from hot H2O solution (w/w solubility is 54% at 10o, 71% at 50o and 84% at 100o. The monohydrate (softens at ~75o and melts at ~100o) dehydrates in air or when heated gently above 40o . The triethylester ( M 276.3, b 127o/1mm, 294o/atm, d 4 1.137, n D 1.4420.) is a bitter tasting oil. [Beilstein 3 H 556 and 568, 3 IV 1272.]

Incompatibilities

Citric acid is incompatible with potassium tartrate, alkali and alkaline earth carbonates and bicarbonates, acetates, and sulfides. Incompatibilities also include oxidizing agents, bases, reducing agents, and nitrates. It is potentially explosive in combination with metal nitrates. On storage, sucrose may crystallize from syrups in the presence of citric acid.

Regulatory Status

GRAS listed. The anhydrous form is accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; IM, IV, and other injections; ophthalmic preparations; oral capsules, solutions, suspensions and tablets; topical and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in Japan and the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Citric acid monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products


Citric acid monohydrate Suppliers

Global( 320)Suppliers
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Shenzhen Sendi Biotechnology Co.Ltd.
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Mainchem Co., Ltd.
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zheyansh@163.com CHINA 3624 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25106 65
Shanghai changwei industrial development co., LTD 13262956501
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View Lastest Price from Citric acid monohydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Citric acid monohydrate
5949-29-1
US $1.00 / KG 1g 99% 100KG career henan chemical co

Citric acid monohydrate Spectrum


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