NOCODAZOLE
- CAS No.
- 31430-18-9
- Chemical Name:
- NOCODAZOLE
- Synonyms
- R 17934;CS-2010;nsc238159;NOCODAZOLE;NSC 238159;Oncodazole;Norcodazole;Nocodazole,98%;Nocodazole,99+%;Nocodazole (R17934)
- CBNumber:
- CB3239975
- Molecular Formula:
- C14H11N3O3S
- Molecular Weight:
- 301.32
- MDL Number:
- MFCD00005588
- MOL File:
- 31430-18-9.mol
- MSDS File:
- SDS
| Melting point | 300 °C (dec.) |
|---|---|
| Density | 1.490 |
| refractive index | 1.6740 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: 10 mg/mL, soluble |
| form | powder |
| pka | 10.67±0.10(Predicted) |
| color | white |
| BRN | 1085978 |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChIKey | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| CAS DataBase Reference | 31430-18-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | SH1WY3R615 |
| EPA Substance Registry System | Nocodazole (31430-18-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H341-H361d | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | T,C,F,Xn | |||||||||
| Risk Statements | 61-40-36/37/38-34-11-68-63 | |||||||||
| Safety Statements | 53-45-36/37/39-26-16-36/37 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DD6521000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | sln-smc 1 ppm/16H MUREAV 141,15,84 | |||||||||
| NFPA 704 |
|
NOCODAZOLE price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 487928 | Nocodazole | 31430-18-9 | 10mg | $96.7 | 2024-03-01 | Buy |
| TCI Chemical | N1138 | Nocodazole | 31430-18-9 | 25MG | $197 | 2024-03-01 | Buy |
| TCI Chemical | N1138 | Nocodazole | 31430-18-9 | 100MG | $566 | 2024-03-01 | Buy |
| Cayman Chemical | 13857 | Nocodazole ≥98% | 31430-18-9 | 5mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 13857 | Nocodazole ≥98% | 31430-18-9 | 10mg | $50 | 2024-03-01 | Buy |
NOCODAZOLE Chemical Properties,Uses,Production
Description
Nocodazole reversibly binds tubulin and alters tubulin-
Chemical Properties
Amber Powder
Uses
Nocodazole has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.
Uses
A potent Tubulin production inhibitor and anti-neoplastic agent
Uses
Antineoplastic;Microtubule poison
Uses
A synthetic chemotherapeutic agent with antineoplastic, antifungal and anthelmintic activities. Microtubule inhibitor; inhibits mitosis
Definition
ChEBI: A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
General Description
White powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
NOCODAZOLE may be sensitive to heat. .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition NOCODAZOLE emits toxic fumes of sulfur oxides and nitrogen oxides.
Fire Hazard
Flash point data for NOCODAZOLE are not available; however, NOCODAZOLE is probably combustible.
Biological Activity
Microtubule inhibitor; inhibits mitosis.
Biochem/physiol Actions
Nocodazole is an anticancer drug that has been shown to interfere with the structure and function of microtubules in interphase and mitotic cells. Malignant cells may be more susceptible to the antimicrotubular effect of nocodazole than nonmalignant cells. Mammalian cells cultured in vitro can be treated with 0.04-10 μg/mL doses for cell synchronization experiments. Prolonged arrest of cells in mitosis due to nocodazole treatment typically results in cell death by apoptosis. Higher concentrations could not be used because of insolubility. High specificity of action may explain low toxicity to bone marrow cells and lack of neurotoxicity. Nocodazole is thought to bind directly to tubulin causing conformational changes resulting in increased exposure of some sulfhydryl and possibly tyrosine residues. Nocodazole′s apparent synergism with cytosine arabinofuranoside has been demonstrated on L1210 leukemic cells.
Safety Profile
Poison by intraperitoneal route.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomposition it emits toxic fumes ofSOx and NOx. See also CARBAMATES
in vitro
nocodazolewas a high-affinity ligand for the cancer-related kinases including abl phosphorylated, c-kit, braf, and mek with the kd values of 0.091 μm, 1.6 μm, 1.8 μm and 1.6 μm, respectively. in addition, the kd for abl(e255k) phosphorylated, abl(t315i) phosphorylated, braf(v600e) and pi3kγ was 0.12 μm, 0.17 μm, 1.1 μm and 1.5 μm, respectively. in chronic lymphocytic leukemia cells, nocodazole induced apoptosis. in some human colon carcinoma cells, nocodazole decrease d apoptosis. also, nocodazole inhibited insulin-stimulated glucose transport. nocodazole impaired the morphology and directionality of migrating medial gan-glionic eminence cells [1]. at high concentrations, nocodazole rapidly depolymerized microtubules in cells, while low concentrations of nocodazole inhibited microtubule dynamic instability [2].in sh-sy5y cells, nocodazole disrupted microtubules by binding to β-tubulin, prevented the formation of one of the two interchain disulfide linkages and impaired the transport of vesicles. nocodazole significantly attenuated meth-induced cell death and lysosomal dysfunction [3]. nocodazole (≥ 50 nm) resulted in a rapid reduction in fibroblast locomotion to a new rate that was maintained for > 2 hours. nocodazole(100 nm) decreased the rate of locomotion by more than 60%; and 300 nm nocodazole completely stopped cell locomotion[4].
in vivo
in athymic mice bearing colo 205 tumor xenografts,after 6 wk of treatment with ketoconazole (50 mg/kg/three times per week)plus nocodazole (5 mg/kg/three times per week), the antitumor effects of nd were significantly potentiated by kt. the tumor volume and tumor weight of the mice are significantly reduced as compared with those treated with ketoconazole or nocodazole alone. nocodazole treatment in combination with ketoconazole strongly enhanced apoptosis of colo 205 tumor xenografts treated with ketoconazole or nocodazole alone [5].
storage
+4°C
References
1) Jordan et al. (1992), Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; J. Cell Science, 102 401 2) Storrie et al. (1998), Dynamics of the interphase mammalian Golgi complex as revealed through drugs producing reversible Golgi disassembly; Biochim. Biophys. Acta, 1404 127 3) Mejillano et al. (1996), Studies on the nocodazole-induced GTPase activity of tubulin; Arch. Biochem. Biophys., 336 130 4) Wang et al. (1998), Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways; J. Biol. Chem., 273 4928
NOCODAZOLE Preparation Products And Raw materials
Raw materials
1of5
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
View Lastest Price from NOCODAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Nocodazole
31430-18-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Nocodazole
31430-18-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-10 | Nocodazole
31430-18-9
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co |
-
- Nocodazole
31430-18-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Nocodazole
31430-18-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Nocodazole
31430-18-9
- US $1.00 / g
- 95-99%
- Career Henan Chemical Co