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Isepamicine

Isepamicine structure

CAS No.: 58152-03-7

Chemical Name:: Isepamicine

Synonyms: hapa-b;sch21420;isepamicin;ISEPAMICINE;hapa-gentamycinb;ISEPAMICIN SULPHATE;Isepamicine USP/EP/BP;(s)-y-1-oxopropyl)-2-deoxy;Isepamicin Sulfate Impurity Ⅲ:Isepamicine;Isepamicin Sulfate Impurity Ⅲ:Isepamicine

CBNumber:: CB3245233

Molecular Formula:: C22H43N5O12

Molecular Weight:: 569.6

MDL Number:: MFCD00864928

MOL File:: 58152-03-7.mol

Last updated:2023-04-24 17:18:42

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Isepamicine Properties

Boiling point	633.08°C (rough estimate)
Density	1.3531 (rough estimate)
refractive index	1.7500 (estimate)
pka	11.01±0.35(Predicted)
FDA UNII	G7K224460P
ATC code	J01GB11

Isepamicine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biorbyt Ltd	orb134569	Isepamicin >99%	58152-03-7	100mg	$510	2021-12-16	Buy
Biorbyt Ltd	orb134569	Isepamicin >99%	58152-03-7	250mg	$765	2021-12-16	Buy
American Custom Chemicals Corporation	ING0005409	ISEPAMICIN 95.00%	58152-03-7	250MG	$1146.05	2021-12-16	Buy
Biorbyt Ltd	orb134569	Isepamicin >99%	58152-03-7	1g	$1504.5	2021-12-16	Buy
American Custom Chemicals Corporation	ING0005409	ISEPAMICIN 95.00%	58152-03-7	1G	$1758.49	2021-12-16	Buy

Product number	Packaging	Price	Buy
orb134569	100mg	$510	Buy
orb134569	250mg	$765	Buy
ING0005409	250MG	$1146.05	Buy
orb134569	1g	$1504.5	Buy
ING0005409	1G	$1758.49	Buy

Isepamicine Chemical Properties,Uses,Production

Description

Isepamicin is a aminoglycoside antibiotic indicated for use in the treatment of urinary and respiratory tract infections. Although it is less potent than most other aminoglycosides, it is also less nephrotoxic. The broad-spectrum activity of isepamicin generally parallels that of amikacin in vitro.

Originator

Schering Plough (USA)

Uses

Antibacterial (aminoglyco side).

brand name

Isepacin; Exacin

Antimicrobial activity

Hydroxyamino propionyl gentamicin B. A semisynthetic derivative of gentamicin B, modified to render it more resistant to microbial inactivation.
In-vitro activity is comparable to or slightly greater than amikacin against Staph. aureus and most enterobacteria; it is much more active against Ser. marcescens, Enterobacter spp. and Klebsiebella pneumoniae. It is also active in vitro against the Mycobacterium avium complex and Nocardia asteroides. It is less susceptible than amikacin or gentamicin to inactivation by β-lactam antibiotics. It retains activity against some strains resistant to most other aminoglycosides.
Pharmacokinetics in neonatal, pediatric, adult, elderly and renally impaired patients are similar to those of other aminoglycosides. In adult volunteers the plasma half-life was 2.1 h. Clearance is reduced in neonates and the elderly. A 7.5 mg/kg once-daily dosage is recommended for children less than 16 days old. No dosage adjustment is required for the elderly unless renal function is impaired. Clearance is proportional to creatinine clearance in patients with chronic renal impairment, and it is eliminated by hemodialysis.
It has been used in respiratory tract infections, urinary tract infections and intra-abdominal infections, in adults and children. It appears to be as effective and well tolerated as amikacin. It is available in Japan.

Isepamicine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Trifluoroacetic acid Isepamicin sulfate

Preparation Products

Isepamicine Suppliers

Global( 73)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3683	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9409	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15746	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
Hebei Duling International Trade Co. LTD	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
GIHI CHEMICALS CO.,LIMITED	58

Clinical Uses of Isepamicin
Isepamicin is inactivated less than gentamicin by high concentration of various penicillins and beta-lactamase inhibitors.
Mar 15，2022

View Lastest Price from Isepamicine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-04-25	Isepamicine 58152-03-7	US $100.00 / kg	1kg	0.99	100 tons	Hebei Duling International Trade Co. LTD
2021-07-20	Isepamicine 58152-03-7	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
2021-07-02	Isepamicine 58152-03-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Isepamicine
58152-03-7
US $100.00 / kg
0.99
Hebei Duling International Trade Co. LTD

Isepamicine
58152-03-7
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Isepamicine
58152-03-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

58152-03-7(Isepamicine)Related Search:

6-Aminocaproic acid Tris(hydroxymethyl)aminomethane ALTRENOGEST Glycine Omeprazole magnesium

Isepamicin sulfate Miboplatin 4-ACETAMIDOCYCLOHEXANOL GENTAMICIN B N-(3-AMINOPROPYL)CYCLOHEXYLAMINE

(1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL (1R,2R)-2-(ETHYLAMINO)CYCLOHEXANOL METHYL 6-AMINO-6-DEOXY-GALACTOPYRANOSIDE 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine AMINO ACIDS

Isepamicine METHYL 6-AMINO-6-DEOXY-GALACTOPYRANOSIDE Nojirimycin

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(s)-y-1-oxopropyl)-2-deoxy hapa-b hapa-gentamycinb 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropionyl]-2-deoxy-D-streptamine isepamicin sch21420 thyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-n(sup1)-(3-amino-2-hydrox ISEPAMICIN SULPHATE (S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)- D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy- (9CI) ISEPAMICINE (2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide (S)-O-6-Amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyrano-syl-(1→6)]-N^<1>^-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-D-streptamine 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropanoyl]-2-deoxy-D-streptamine Isepamicin Sulfate Impurity Ⅲ:Isepamicine D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy- Isepamicine USP/EP/BP (S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol Isepamicin Sulfate Impurity Ⅲ:Isepamicine 58152-03-7 C22H43N5O12