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ChemicalBook >> CAS DataBase List >>1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Structure
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE structure
CAS No.
866396-34-1
Chemical Name:
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
Synonyms
DPPI 1C HCL;DPPI 1C HYDROCHLORIDE;Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem;2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel-;1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
CBNumber:
CB32453447
Molecular Formula:
C14H20N4O2
Molecular Weight:
276.33
MDL Number:
MFCD09971138
MOL File:
866396-34-1.mol
MSDS File:
SDS
Last updated:2023-05-18 11:30:58
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1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Properties

storage temp. Desiccate at RT
solubility Soluble in DMSO > 10 mM
form White solid

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 317641 Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem 866396-34-1 5mg $294 2023-01-07 Buy
Tocris 2783 DPPI1chydrochloride ≥98%(HPLC) 866396-34-1 1 $116 2021-12-16 Buy
Tocris 2783 DPPI1chydrochloride ≥98%(HPLC) 866396-34-1 10 $248 2021-12-16 Buy
Usbiological 255195 DPPI 1c hydrochloride 866396-34-1 1mg $360 2021-12-16 Buy
ApexBio Technology A4425 DPPI1chydrochloride 866396-34-1 10mg $380 2021-12-16 Buy
Product number Packaging Price Buy
317641 5mg $294 Buy
2783 1 $116 Buy
2783 10 $248 Buy
255195 1mg $360 Buy
A4425 10mg $380 Buy

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Chemical Properties,Uses,Production

General Description

An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.

Biological Activity

Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC 50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC 50 > 30 μ M). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Absin Bioscience Inc. 021-38015121 15000105423 chenjw@absin.cn China 24734 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
AdooQ BioScience, LLC 58
Sigma-Aldrich 80
EMMX Biotechnology LLC 60
Absin Bioscience Inc. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
ApexBio Technology 58

866396-34-1(1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE)Related Search:

(S)-Pyrrolidine-2-carbonitrile hydrochloride (S)-PYRROLIDINE-2-CARBONITRILE (R)-PYRROLIDINE-2-CARBONITRILE HYDROCHLORIDE 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE DPPI 1C HYDROCHLORIDE DPPI 1C HCL Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem 2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel- 866396-34-1 C14H20N4O2HCl