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Phthalide

Phthalide structure

CAS No.: 87-41-2

Chemical Name:: Phthalide

Synonyms: Isobenzofuran-1(3H)-one;1(3H)-ISOBENZOFURANONE;ISOBENZOFURANONE;2-Benzofuran-1(3H)-one;PHTHALIDE;Phthalanone;AKOS 243-03;OXOPHTHALANE;Phthalide99%;Phthalide>

CBNumber:: CB3245950

Molecular Formula:: C8H6O2

Molecular Weight:: 134.13

MDL Number:: MFCD00005906

MOL File:: 87-41-2.mol

MSDS File:: SDS

Last updated:2023-11-28 16:31:44

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Phthalide Properties

Melting point	71-74 °C (lit.)
Boiling point	290 °C (lit.)
Density	1.1
refractive index	1.5360 (estimate)
FEMA	4195 \| PHTHALIDE
Flash point	152 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Crystalline Powder
color	White to light beige
Odor	at 100.00 %. sweet tonka coumarin powdery coconut phenolic lactonic
Odor Type	coumarinic
Water Solubility	sparingly soluble
BRN	114632
Dielectric constant	36.0（23℃）
InChIKey	WNZQDUSMALZDQF-UHFFFAOYSA-N
LogP	0.99
CAS DataBase Reference	87-41-2(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	PHTHALIDE
EWG's Food Scores	1
FDA UNII	8VV922U86J
NIST Chemistry Reference	1(3H)-Isobenzofuranone(87-41-2)
EPA Substance Registry System	Phthalide (87-41-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280-P337+P313-P305+P351+P338

Hazard Codes

Risk Statements

36-36/37/38

Safety Statements

26-36-24/25-37/39

WGK Germany

RTECS

TI3520000

TSCA

Yes

HS Code

29322980

NFPA 704

	0
2		0

Phthalide price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P39605	Phthalide 98%	87-41-2	100g	$48	2024-03-01	Buy
Sigma-Aldrich	55906	Phthalide analytical standard	87-41-2	100mg	$67.8	2022-05-15	Buy
TCI Chemical	P0401	Phthalide >98.0%(GC)	87-41-2	25g	$16	2024-03-01	Buy
TCI Chemical	P0401	Phthalide >98.0%(GC)	87-41-2	500g	$90	2024-03-01	Buy
Alfa Aesar	A15516	Phthalide, 98+%	87-41-2	100g	$29.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
P39605	100g	$48	Buy
55906	100mg	$67.8	Buy
P0401	25g	$16	Buy
P0401	500g	$90	Buy
A15516	100g	$29.65	Buy

Phthalide Chemical Properties,Uses,Production

Description

White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.
Phthalide powder

Uses

Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors.

Definition

ChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.

Aroma threshold values

Low strength odor, Tonka type.

Taste threshold values

Sweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.

Synthesis Reference(s)

Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
Tetrahedron Letters, 7, p. 6097, 1966

Flammability and Explosibility

Not classified

Pharmacology

Systemic fungicide giving effective preventive control of the rice blast fungus in rice as foliar spray.

Purification Methods

Crystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]

Toxicity evaluation

Mammalian toxicology. Oral: Acute oral LD₅₀ for rats and mice >10000 mg/kg. Skin and eye: Acute percutaneous LD₅₀ for rats and mice >10000 mg/kg. Not a shaved skin irritant, eye irritant (rabbits). Inhalation LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats 2000, mice 100 mg/kg diet.

Phthalide synthesis

Synthesis of Phthalide from carbon monoxide and 2-Iodobenzyl alcohol

Phthalide Preparation Products And Raw materials

Raw materials

ZINC Phthalimide Copper(II) sulfate 1H-Isobenzofurylium, 3-ethoxy-, tetrafluoroborate(1-) (9CI) 3-Isopropylbenzophenone

Methanone, (3-ethenylphenyl)phenyl- ethyl 2-(dibromomethyl)benzoate 3,3-dimethyl-1H-isobenzofuran

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Preparation Products

1,4-DICHLOROANTHRAQUINONE 2-(Bromomethyl)benzoic acid PYRIFTALID 2-Carboxybenzaldehyde 2-(Phenoxymethyl)benzoic acid

Doxepin hydrochloride 6-bromoisoindolin-1-one 2-(CYANOMETHYL)BENZOIC ACID 1-CHLORO-4-(4-PYRIDINYLMETHYL)PHTHALAZINE 2-P-ANISYL-1,3-INDANDIONE

5-CHLORO-2-FORMYL-BENZOIC ACID

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Phthalide Suppliers

Global( 498)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	tinayang@enbridgepharm.com	China	303	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Zibo Shiji Zhonglian Medical Technology Co., Ltd.	15069388126 15069388126	sales@sjzlpharm.com	China	61	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58

Supplier	Advantage
ENBRIDGE PHARMTECH CO., LTD.	58
changzhou huayang technology co., ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Zibo Shiji Zhonglian Medical Technology Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58

Synthesis of phthalide and its biological information
Phthalide is a natural product found in Ligusticum sinense and Ligusticum chuanxiong with data available.
Aug 25，2022

View Lastest Price from Phthalide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	Phthalide 87-41-2	US $0.00 / Kg/Drum	1KG	99%	100mt	Jinan Finer Chemical Co., Ltd
2024-04-11	Butylphthalide Impurity 4（Chlortalidone Impurity 7） 87-41-2	US $0.00-0.00 / mg	10mg	99.16%	10g/month	Guangzhou Tosun Pharmaceutical Limited
2023-09-15	2-benzofuran-1(3H)-one 87-41-2	US $0.00 / kg	1kg	0.99	5000kg	Hebei Yanxi Chemical Co., Ltd.

Phthalide
87-41-2
US $0.00 / Kg/Drum
99%
Jinan Finer Chemical Co., Ltd

Butylphthalide Impurity 4（Chlortalidone Impurity 7）
87-41-2
US $0.00-0.00 / mg
99.16%
Guangzhou Tosun Pharmaceutical Limited

2-benzofuran-1(3H)-one
87-41-2
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

Phthalide Spectrum

Phthalide(87-41-2)MS Phthalide(87-41-2)¹HNMR Phthalide(87-41-2)¹³CNMR Phthalide(87-41-2)IR1 Phthalide(87-41-2)IR2 Phthalide(87-41-2)IR3 Phthalide(87-41-2)Raman

87-41-2(Phthalide)Related Search:

3-(Trifluoromethyl)benzoic acid p-Toluic acid Methyl 4-methylbenzoate Methyl 4-(bromomethyl)benzoate m-Toluic acid

o-Toluic acid ISOCHROMAN-4-ONE IsochroMan-4-ol 3,4-DIHYDRO-1H-ISOCHROMEN-3-OL 1H-2-Benzopyran-6-ol, 3,4-dihydro- (9CI)

(+)-Bicuculline Pyromellitic Dianhydride ERYTHROSIN B 5(6)-Aminofluorescein Fluorescein diacetate

6-Aminofluorescein Fluorescein isothiocyanate Anthranilic acid

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3H-2-Benzofuran-1-one 1,3-Dihydroisobenzofuran-1-one Phthalanone Phthalide,1-Isobenzofuranone Phthalide, 99% 5GR PHTHALIDE FOR SYNTHESIS 100 G PHTHALIDE FOR SYNTHESIS 250 G Phthalide 98% O-Hydroxymethylbenzoic Acid Lactone (Phthalanone) SPECS AE-641/30105043 PHTHALIDE OXOPHTHALANE O-HYDROXYMETHYLBENZOIC ACID LACTONE 1,3-Dihydrobenzo[C]furan-2-one 2-Hydroxymethylbenzoic acid, gamma-lactone Phthalolactone 1-PHTHALANONE 1-OXOPHTHALAN 2-BENZOFURAN-(3H)-ONE 1-ISOBENZOFURANONE 1,3-DIHYDROBENZO[C]FURAN-1-ONE Phthalide99% Phthalide, 96+% Phthalide,98+% α-Hydroxy-o-toluic acid lactone AKOS 243-03 A-HYDROXY-O-TOLUIC ACID LACTONE BENZO(C)FURAN-2-ONE LABOTEST-BB LT00068498 PHTHALIDE pure 2-Hydroxymethylbenzoic acid g-lactone Chlortalidone Impurity 7 Butylphthalide Impurity 4 Phthalide 1(3H)-Isobenzofuranone Chlortalidone Impurity 17 o-Hydruxymethy/benzoic acid lactone Phthalide> 1-Isobenzofuranone (Phthalide)@100 μg/mL in Methanol 1-Isobenzofuranone (Phthalide) 2-Benzofuran-1(3H)-one 1(3H)-ISOBENZOFURANONE Isobenzofuran-1(3H)-one ISOBENZOFURANONE Phthalide (6CI, 8CI) Butylphthalide Impurity 4（Chlortalidone Impurity 7） 87-41-2 C6H4COOCH2 Building Blocks Benzofurans Carbonyl Compounds Organic Building Blocks Lactones Heterocyclic Building Blocks Building Blocks Carbonyl Compounds Chemical Synthesis Lactones Organic Building Blocks