ChemicalBook >> CAS DataBase List >>Avagacestat (BMS-708163)

Avagacestat (BMS-708163)

CAS No.
1146699-66-2
Chemical Name:
Avagacestat (BMS-708163)
Synonyms
CS-262;BMS-708163;Avagacestat;BMS-708163, >=98%;BMS708163;BMS 708163;BMS-708163 (Avagacestat);Avagacestat (BMS-708163);BMS708163;BMS 708163;AVAGACESTAT;Avagacestat BMS-708163 BMS708163;(R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoro
CBNumber:
CB32470907
Molecular Formula:
C20H17ClF4N4O4S
Molecular Weight:
520.89
MDL Number:
MFCD13195458
MOL File:
1146699-66-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

Avagacestat (BMS-708163) Properties

Density 1.488
storage temp. Store at -20°C
solubility insoluble in H2O; ≥177.6 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form Powder
FDA UNII TQ44WWY45Q

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

Avagacestat (BMS-708163) price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16711 Avagacestat ≥98% 1146699-66-2 1mg $44 2024-03-01 Buy
Cayman Chemical 16711 Avagacestat ≥98% 1146699-66-2 5mg $193 2024-03-01 Buy
Cayman Chemical 16711 Avagacestat ≥98% 1146699-66-2 10mg $341 2024-03-01 Buy
Tocris 6363 Avagacestat ≥98%(HPLC) 1146699-66-2 5 $72 2021-12-16 Buy
Tocris 6363 Avagacestat ≥98%(HPLC) 1146699-66-2 25 $278 2021-12-16 Buy
Product number Packaging Price Buy
16711 1mg $44 Buy
16711 5mg $193 Buy
16711 10mg $341 Buy
6363 5 $72 Buy
6363 25 $278 Buy

Avagacestat (BMS-708163) Chemical Properties,Uses,Production

Uses

Avagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.

Definition

ChEBI: Avagacestat is an oxadiazole and a ring assembly.

Biological Activity

bms-708163 is a potent selective and orally bioavailable inhibitor of γ-secretase with ic50 value of 0.3nm [1].the cleavage of amyloid precusor protein app by γ-secretase causes the production of aβ40 and aβ42, which are cytotoxic and cause ad. in vitro assay shows bms-708163 inhibits the formation of aβ40 and aβ42 in h4-8sw cells. it also inhibits the human recombinant cyps in vitro with ic50 value of 20μm. notch receptor is another substrate of γ-secretase. the inhibition of notch signal pathway results in some side effects. it is shown that the activity of bms-708163 to inhibit notch is 190-fold weaker than to app. in female rats, oral administration of bms-708163 significantly reduces the production of aβ in plasma and brain at 10mg/kg and 100mg/kg. in addition, bms-708163 also reduces aβ in brain and csf in male beagle dogs [1].

target

γ-secretase

storage

Store at +4°C

References

[1] gillman kw, starrett je jr, parker mf, xie k, bronson jj, marcin lr, mcelhone ke, bergstrom cp, mate ra, williams r, meredith je jr, burton cr, barten dm, toyn jh, roberts sb, lentz ka, houston jg, zaczek r, albright cf, decicco cp, macor je, olson re. discovery and evaluation of bms-708163, a potent, selective and orally bioavailable γ-secretase inhibitor. acs med chem lett. 2010 mar 22;1(3):120-4.

1146699-64-0
1146699-67-3
1146699-66-2
Synthesis of Avagacestat (BMS-708163) from 1,2,4-Oxadiazole, 3-[4-(broMoMethyl)-3-fluorophenyl]- and PentanaMide, 2-[[(4-chlorophenyl)sulfonyl]aMino]-5,5,5-trifluoro-, (2R)-
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View Lastest Price from Avagacestat (BMS-708163) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Avagacestat pictures 2023-06-26 Avagacestat
1146699-66-2
US $200.00 / kg 1kg 99% 1000kg/Month Hebei Mingeng Biotechnology Co., Ltd
	Avagacestat (BMS-708163) pictures 2020-01-13 Avagacestat (BMS-708163)
1146699-66-2
US $6.68 / KG 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co
  • Avagacestat pictures
  • Avagacestat
    1146699-66-2
  • US $200.00 / kg
  • 99%
  • Hebei Mingeng Biotechnology Co., Ltd

Avagacestat (BMS-708163) Spectrum

(2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]amino]-5,5,5-trifluoropentanamide BMS-708163 (R)-2-(4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide BMS-708163 (Avagacestat) Avagacestat Avagacestat (BMS-708163) (R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoropen (2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide (2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]amino]-5,5,5-trifluoropentanamide BMS-708163 BMS-708163, >=98% (2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-pentanamide (R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoro BMS708163;BMS 708163 CS-262 BMS708163;BMS 708163;AVAGACESTAT Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)- Avagacestat BMS-708163 BMS708163 (2R)-[(4-Chloro-benzenesulfonyl)-(2-fluoro-4-[1,2,4]oxadiazol-3-yl-benzyl)-amino]-5,5,5-trifluoro-pentanoic acid amide 1146699-66-2 C20H17ClF4N4O4S Inhibitors