Decursin
- CAS No.
- 5928-25-6
- Chemical Name:
- Decursin
- Synonyms
- Decurson;DECURSIN;(S)-(+)-decursin;DECURSIN USP/EP/BP;DECURSINOL ANGELATE;Decursin ((+)-Decursin);Decursin (Synonyms: (+)-Decursin);Decursin, 98%, from Angelica decursiva (Miq.) Franch. & Sav.;(S)-2,2-dimethyl-8-oxo-2,3,4,8-tetrahydropyrano[3,2-g]chromen-3-yl 3-methylbut-2-enoate;(7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate
- CBNumber:
- CB3247101
- Molecular Formula:
- C19H20O5
- Molecular Weight:
- 328.36
- MDL Number:
- MFCD00272154
- MOL File:
- 5928-25-6.mol
- MSDS File:
- SDS
| Melting point | 93-94℃ |
|---|---|
| Boiling point | 469.4±45.0 °C(Predicted) |
| Density | 1.24 |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +120 to +160°, c = 0.5 in chloroform-d |
| InChI | InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1 |
| InChIKey | CUKSFECWKQBVED-INIZCTEOSA-N |
| SMILES | C(O[C@@H]1C(C)(C)OC2=C(C1)C=C1C(=C2)OC(=O)C=C1)(=O)/C=C(/C)\C |
| FDA UNII | E95RTO3YQR |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 29322090 |
Decursin price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0786 | Decursin ≥97% (HPLC) | 5928-25-6 | 1mg | $64.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0786 | Decursin ≥97% (HPLC) | 5928-25-6 | 5mg | $425 | 2024-03-01 | Buy |
| Cayman Chemical | 25214 | Decursin ≥98% | 5928-25-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 25214 | Decursin ≥98% | 5928-25-6 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 25214 | Decursin ≥98% | 5928-25-6 | 10mg | $184 | 2024-03-01 | Buy |
Decursin Chemical Properties,Uses,Production
Description
Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities. It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM. In vivo, decursin (10 mg/kg, i.p.) reduces tumor growth in a B16/F10 mouse xenograft model. Decursin inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice. In a mouse model of seizures induced by kainic acid , decursin (20 mg/kg) increases latency to the first electroencephalographic (EEG) discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex. Decursin inhibits tube formation and expression of VEGF receptor 2 (VEGFR2) in human retinal microvascular endothelial cells (HRMECs) and human umbilical vein endothelial cells (HUVECs) in vitro and reduces retinal expression of VEGFR2 and neovascularization in rats with diabetes induced by streptozotocin . It also reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of reactive oxygen species (ROS) in a mouse model of CCL4-induced liver fibrosis.
Uses
Decursin is a bioactive metabolites from the root of Angelica gigas Nakai which exhibits neuro-protective and cognitive enhancement effects. Human monoamine oxidase (MAO) inhibitor. Also, it could be useful for the treatment of bone associated with excessive bone resorption.
Definition
ChEBI: Decursin is a member of coumarins.
Biochem/physiol Actions
Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.
Side effects
It is important to note that Decursin has not been approved by the FDA for any medical use and there is limited research on its safety and effectiveness. Possible side effects of Decursin include nausea, vomiting, diarrhea, abdominal pain, dizziness, headache, and rash. It may also interact with certain medications, so it is important to consult with a healthcare professional before taking Decursin. Additionally, Decursin may not be safe for pregnant or breastfeeding women, as well as those with certain medical conditions.
target
NADPH-oxidase | TGF-β/Smad | AChR | NF-kB | MMP(e.g.TIMP) | p38MAPK | PKC | p53 | P450 (e.g. CYP17) | VEGFR | JNK | LTR | IL Receptor | TNF-α
Decursin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
