Lumacaftor (VX-809)
- CAS No.
- 936727-05-8
- Chemical Name:
- Lumacaftor (VX-809)
- Synonyms
- Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;VRT 826809;3-(6-{[1-(2;VX809;VX-809;VX 809, >=98%
- CBNumber:
- CB32489655
- Molecular Formula:
- C24H18F2N2O5
- Molecular Weight:
- 452.41
- MDL Number:
- MFCD16659051
- MOL File:
- 936727-05-8.mol
- MSDS File:
- SDS
| Melting point | 200-205oC |
|---|---|
| Boiling point | 653.0±55.0 °C(Predicted) |
| Density | 1.51 |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.95±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | EGP8L81APK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Lumacaftor (VX-809) price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 10mg | $266 | 2024-03-01 | Buy |
| Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 25mg | $573 | 2024-03-01 | Buy |
| Usbiological | 273822 | VX-809 | 936727-05-8 | 50mg | $389 | 2021-12-16 | Buy |
Lumacaftor (VX-809) Chemical Properties,Uses,Production
Uses
VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.
Biological Activity
vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several
target
CFTR
Lumacaftor (VX-809) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7613 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1175 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
View Lastest Price from Lumacaftor (VX-809) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Lumacaftor (VX-809)
936727-05-8
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-09 | Lumacaftor (VX-809)
936727-05-8
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-07-15 | Lumacaftor (VX-809)
936727-05-8
|
US $0.00 / KG | 0.1KG | 98% | 1000KGS | Zhengzhou Anbu Chem Co.,Ltd |
-
- Lumacaftor (VX-809)
936727-05-8
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Lumacaftor (VX-809)
936727-05-8
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- Lumacaftor (VX-809)
936727-05-8
- US $0.00 / KG
- 98%
- Zhengzhou Anbu Chem Co.,Ltd