ChemicalBook >> CAS DataBase List >>Slv320
Slv320
- CAS No.
- 251945-92-3
- Chemical Name:
- Slv320
- Synonyms
- Slv320;SC-204288;Derenofylline;SLV320 >=98% (HPLC);SLV320; SLV-320; SLV 320; DERENOFYLLINE;4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol;(1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol;trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol;Cyclohexanol, 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-;Cyclohexanol, 4-((2-phenyl-1H-pyrrolo(2,3-D)pyrimidin-4-yl)amino)-, trans-
- CBNumber:
- CB32492503
- Molecular Formula:
- C18H20N4O
- Molecular Weight:
- 308.38
- MDL Number:
- MOL File:
- 251945-92-3.mol
Last updated:2023-05-18 11:31:03
| Boiling point | 532.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| form | Powder |
| pka | 15.15±0.40(Predicted) |
| FDA UNII | O1Q96UZ63W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Slv320 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27666 | Derenofylline | 251945-92-3 | 5mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 27666 | Derenofylline | 251945-92-3 | 25mg | $371 | 2024-03-01 | Buy |
| Cayman Chemical | 27666 | Derenofylline | 251945-92-3 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 27666 | Derenofylline | 251945-92-3 | 10mg | $166 | 2024-03-01 | Buy |
| Tocris | 3344 | SLV320 ≥99%(HPLC) | 251945-92-3 | 10 | $181 | 2021-12-16 | Buy |
Slv320 Chemical Properties,Uses,Production
Description
Derenofylline is an adenosine A1 receptor antagonist (Ki = 1 nM). It is selective for adenosine A1 over A2A, A2B, and A3 receptors (Kis = 398, 3,981, and 200 nM, respectively). It decreases adenosine A1 receptor-mediated adenosine-induced bradycardia in rats (ED50 = 0.49 mg/kg) but reduces A2 receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC50 = 58.6 nM) in an adenosine A1 receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 μM.
Uses
SLV 320 is an A1 antagonist.
Slv320 Preparation Products And Raw materials
Raw materials
Preparation Products
Slv320 Suppliers
Global( 46)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
Cyclohexanol, 4-((2-phenyl-1H-pyrrolo(2,3-D)pyrimidin-4-yl)amino)-, trans-
Slv320
trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
(1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol
SC-204288
Derenofylline
4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
SLV320; SLV-320; SLV 320; DERENOFYLLINE
Cyclohexanol, 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-
SLV320 >=98% (HPLC)
rel-(1r,4r)-4-((2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexan-1-ol
Inhibitor,P1 receptor,Derenofylline,Adenosine Receptor,SLV320,fibrosis,uraemic,SLV-320,cardiomyopathy,SLV 320,inhibit,Nephrectomy
251945-92-3