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Unii-na83F1sjsr

Unii-na83F1sjsr Structure
Unii-na83F1sjsr structure
CAS No.
706782-28-7
Chemical Name:
Unii-na83F1sjsr
Synonyms
PiMavanserin Tartrate;Nuplazid;ACP-103;BVF-048;Unii-na83F1sjsr;ACP-103 tartrate;8-Octanedioic acid;Pimavanserin tartrare;Pimavanserin tartrate vv;Pimavanserin L-Hetartrate
CBNumber:
CB32494118
Molecular Formula:
C29H40FN3O8
Molecular Weight:
577.65
MDL Number:
MFCD09970919
MOL File:
706782-28-7.mol
MSDS File:
SDS
Last updated:2024-03-27 16:59:26
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Unii-na83F1sjsr Properties

storage temp. Store at -20°C
solubility DMSO:70.0(Max Conc. mg/mL);69.6(Max Conc. mM)
FDA UNII NA83F1SJSR

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05
Signal word  Danger
Hazard statements  H318-H317-H302+H332
Precautionary statements  P280-P305+P351+P338-P310-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
HS Code  29299090

Unii-na83F1sjsr price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P441810 PimavanserinTartrate 706782-28-7 5mg $160 2021-12-16 Buy
AK Scientific 4806BB Pimavanserintartrate 706782-28-7 10mg $164 2021-12-16 Buy
Biosynth Carbosynth BP164269 Pimavanserin tartrate 706782-28-7 50mg $297.5 2021-12-16 Buy
ChemScene CS-7954 Pimavanserintartrate 99.47% 706782-28-7 25mg $50 2021-12-16 Buy
ChemScene CS-7954 Pimavanserintartrate 99.47% 706782-28-7 50mg $80 2021-12-16 Buy
Product number Packaging Price Buy
P441810 5mg $160 Buy
4806BB 10mg $164 Buy
BP164269 50mg $297.5 Buy
CS-7954 25mg $50 Buy
CS-7954 50mg $80 Buy

Unii-na83F1sjsr Chemical Properties,Uses,Production

Description

Pimavanserin, developed by San Diego-based Acadia Pharmaceuticals, is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist. The USFDA approved this once-daily drug to treat the delusions and hallucinations associated with psychosis as a function of Parkinson’s disease. Pimavanserin has a unique mechanism of action relative to other antipsychotics, behaving as a selective inverse agonist of the serotonin 5-HT2A receptor while exhibiting 40-fold selectivity over the 5-HT2C receptor and having no significant affinity or activity with the 5-HT2B or dopamine receptors.

Uses

Pimavanserin tartrate is a 5-HT2A inverse agonist that reverses psychosis-like behaviours and has the potential to treat various other neuropsychiatric disorders such as schizophrenia and Parkinson’s disease.

Definition

ChEBI: A tartrate salt that is the hemitartrate salt of pimavanserin. An atypical antipsychotic that is used for treatment of hallucinations and delusions associated with Parkinson's disease.

Synthesis

Three patent applications filed by Acadia described the process-scale synthetic approach to pimavanserin. The kilogram-scale synthesis began with the alkylation of commercially available 4-hydroxybenzaldehyde (123) with isobutyl bromide (124) under basic conditions. Condensation of the resultant benzaldehyde 125 with hydroxylamine furnished the corresponding oxime 126 in 63% yield from 123. Hydrogenation of 126 catalyzed by Pd/C under acidic conditions produced benzylamine 127, which was isolated as the acetate salt in 41% yield. This compound underwent sodium hydroxide workup followed by reaction with HCl gas and phosgene to deliver isocyanate 128. Nucleophilic attack of this isocyanate by benzylamine 129 (prepared from reductive amination of commercially available N-methylpiperid-4-one 130 with 4-fluorobenzylamine 131) followed by salt formation using tartaric acid in aqueous isopropyl acetate, and THF completed the synthesis of pimavanserin tartrate (XI) in 50% yield over the two-step protocol and a 10.6% overall yield from 123.

Synthesis_706782-28-7

Unii-na83F1sjsr Preparation Products And Raw materials

Raw materials

Preparation Products

Unii-na83F1sjsr Suppliers

Global( 143)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 7838 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Shenzhen Excellent Biotech Co., Ltd. 		58

View Lastest Price from Unii-na83F1sjsr manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pimavanserin Impurity reference pictures 2024-03-27 Pimavanserin Impurity reference
706782-28-7
 US $0.00 / mg 10mg 0.98 10g ShenZhen H&D Pharmaceutical Technology Co., LTD
Pimavanserin Tartrate pictures 2023-11-01 Pimavanserin Tartrate
706782-28-7
 US $0.00-0.00 / g 1g 98% 100kg Hangzhou ICH Biofarm Co., Ltd
Pimavanserin Tartrate pictures 2022-05-18 Pimavanserin Tartrate
706782-28-7
 US $0.00 / g 10g 99.0% 10tons Wuhan Godbullraw Chemical Co.,ltd

Unii-na83F1sjsr Spectrum

Unii-na83F1sjsr(706782-28-7)1HNMR

706782-28-7(Unii-na83F1sjsr)Related Search:

L(+)-Ornithine hydrochloride Pimavanserin 1,3-bis(4-isobutoxybenzyl)urea Bis(4-fluorobenzyl)aMine Pimavanserin
N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine Pimavanserin

1of2

N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide Unii-na83F1sjsr Pimavanserin tartrate or ACP 103 BVF-048 Pimavanserin tartrate,nuplazid N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]urea (2R,3R)-2,3-dihydroxybutanedioate (2:1) N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]urea (2R,3R)-2,3-dihydroxybutanedioate Urea,N-[(4-fluorobenzyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]-,(2R,3R)-2,3-dihydroxybutanediooate(2:1) ACP-103 tartrate 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea hemi((2R,3R)-2,3-dihydroxysuccinate) Pimavanserin tartrare 8-Octanedioic acid Pimavanserin Impurity reference Pimo van Serine L-tartrate Nuplazid ACP-103 PiMavanserin Tartrate Pimavanserin tartaric acid Pimavanserin tartrate vv Pimavanserin L-Hetartrate 706782-28-7 2C25H34FN3O2C4H6O6 C54H74F2N6O10