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Bromhexine hydrochloride

Bromhexine hydrochloride
Bromhexine hydrochloride structure
CAS No.
611-75-6
Chemical Name:
Bromhexine hydrochloride
Synonyms
bisolvon;Cofmesin;Hapysuol;Coughtimi;bromessina;Bisopollon;LABOTEST-BB;BREVISCAPINE;Bromexine Hcl;BROMHEXINE HCL
CBNumber:
CB3249453
Molecular Formula:
C14H21Br2ClN2
Formula Weight:
412.59
MOL File:
611-75-6.mol

Bromhexine hydrochloride Properties

Melting point:
240-244 °C
storage temp. 
Sealed in dry,Room Temperature
solubility 
Very slightly soluble in water, slightly soluble in alcohol and in methylene chloride.
form 
powder
λmax
307nm(Decane)(lit.)
Merck 
14,1391
BRN 
4848376
InChIKey
UCDKONUHZNTQPY-UHFFFAOYSA-N
CAS DataBase Reference
611-75-6(CAS DataBase Reference)
FDA UNII
YC2ZOM3Z8V
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  2
RTECS  XS9950000
HS Code  29215990

Bromhexine hydrochloride price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 17343 Bromhexine hydrochloride ≥98.0% (AT) 611-75-6 25g $40.9 2020-08-18 Buy
Sigma-Aldrich 51082 Bromhexine hydrochloride analytical standard 611-75-6 100mg $114 2021-03-22 Buy
Sigma-Aldrich B1145000 Bromhexine hydrochloride European Pharmacopoeia (EP) Reference Standard 611-75-6 $190 2021-03-22 Buy
Sigma-Aldrich Y0001757 Bromhexine for system suitability European Pharmacopoeia (EP) Reference Standard 611-75-6 $190 2021-03-22 Buy
TCI Chemical B4054 Bromhexine Hydrochloride >98.0%(HPLC)(N) 611-75-6 25g $38 2021-03-22 Buy

Bromhexine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Bisolvon,Boehringer Ingelheim,Switz.,1963

Uses

antibacterial

Uses

Expectorant; mucolytic.

Uses

Antimucolytic

Definition

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of spu um).

Manufacturing Process

In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted and that initial product reacted with hydrazine to give N-(2-aminobenzyl)-Nmethyl- cyclohexylamine.
A solution of 29.3 g of bromine in 50 cc of glacial acetic acid was slowly added dropwise to a solution of 159 g of N-(2-aminobenzyl)-N-methylcyclohexylamine, accompanied by stirring. The glacial acetic acid was decanted from the precipitate formed during the addition of the bromine solution, and the precipitate was thereafter shaken with 200 cc of 2N sodium hydroxide and 600cc of chloroform until all of the solids went into solution. The chloroform phase was allowed to separate from the aqueous phase. The chloroform phase was decanted, evaporated to dryness and the residue was dissolved in absolute ether. The resulting solution was found to be a solution of N-(2-amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine in ethanol. Upon introducing hydrogen chloride into this solution, the hydrochloride of N-(2- amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine precipitated out. It had a melting point of 232°-235°C (decomposition).

Therapeutic Function

Expectorant; Mucolytic

Bromhexine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Bromhexine hydrochloride Suppliers

Global( 365)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 154 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 136 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5361 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58

View Lastest Price from Bromhexine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-08 Bromhexine hydrochloride
611-75-6
US $35.00 / KG 1g 99% 1000kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-09-29 Bromhexine hydrochloride
611-75-6
US $1.00 / KG 1KG ≥99.0% 5tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-14 Bromhexine hydrochloride
611-75-6
US $79.50-1155.00 / Kg/Drum 25KG 99% 1000kg Baoji Guokang Healthchem co.,ltd

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