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PYRVINIUM PAMOATE

Pharmacology and mechanism of action Indications Side effects Preparations References
PYRVINIUM PAMOATE
PYRVINIUM PAMOATE structure
CAS No.
3546-41-6
Chemical Name:
PYRVINIUM PAMOATE
Synonyms
tru;povan;pyrcon;Poquil;povanyl;altolat;alnoxin;molevac;pamovin;sn-4395
CBNumber:
CB3249600
Molecular Formula:
C75H70N6O6
Formula Weight:
1151.39
MOL File:
3546-41-6.mol

PYRVINIUM PAMOATE Properties

Melting point:
210-215° (softens at 190°)
Boiling point:
829.27°C (rough estimate)
Density 
1.0104 (rough estimate)
refractive index 
1.6400 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
powder
color 
red
FDA UNII
310X6S84LW
NCI Drug Dictionary
pyrvinium pamoate
ATC code
P02CX01
EPA Substance Registry System
Pyrvinium pamoate (3546-41-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H351-H302-H312-H332
Precautionary statements  P261-P280-P301+P312+P330-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38-40
Safety Statements  26-36
WGK Germany  3
HS Code  2933492250

PYRVINIUM PAMOATE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0027 Pyrvinium pamoate salt hydrate ≥98% (HPLC) 3546-41-6 10mg $118 2021-12-16 Buy
Sigma-Aldrich 1592001 Pyrvinium pamoate United States Pharmacopeia (USP) Reference Standard 3546-41-6 500mg $366 2021-12-16 Buy
TRC P999010 Pyrvinium pamoate 3546-41-6 100mg $445 2021-12-16 Buy
Biorbyt Ltd orb611523 Pyrvinium pamoate 3546-41-6 100 mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb573378 pyrvinium >98% 3546-41-6 100 mg $542.3 2021-12-16 Buy

PYRVINIUM PAMOATE Chemical Properties,Uses,Production

Pharmacology and mechanism of action

Pyrvinium is a quaternary ammonium derivative of a cyanine dye with marked effect against Enterobius vermicularis.
The mechanism of action is not well known. The drug inhibits oxidative metabolism in the worms and interferes with the absorption of glucose in intestinal helminths. Since most intestinal worms are dependent on anaerobic carbohydrate metabolism, this may be an important action of the drug[1].
 

Indications

Infections caused by Enterobius vermicularis. Pyrvinium is largely replaced today by more effective and safer drugs such as albendazole and mebendazole.
 

Side effects

Gastrointestinal disturbances such as nausea, vomiting, dyspepsia, indigestion and abdominal pain are frequent. Allergic reactions and photosensitivity have been reported. Pyrvinium stains the stool bright red and may stain clothing if vomiting occurs. Patients should be informed about this.
 

Preparations

Pyrvinium pamoate (embonate): 450 mg of the pamoate is equivalent to 300 mg of pyrvinium.
• Povanyl ® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tablets 50 mg pyrvinium.
• Vanquin® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tab pyrvinium.

References

1. Buchanan RA, Barrow WB, Heffelfinger JC, Kinkel AW, Smith TC, Turner JL (1974). Pyrvinium pamoate. Clin Pharmacol Ther, 16, 716–719.

Uses

anthelmintic

Uses

Pyrvinium Pamoate is a potent noncompetitive inhibitor of the androgen receptor, with the application towards prostate cancer treatment. Antihelmintic.

brand name

Povan (Parke-Davis).

General Description

Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .

Fire Hazard

Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.

Biochem/physiol Actions

Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.

PYRVINIUM PAMOATE Preparation Products And Raw materials

Raw materials

Preparation Products


PYRVINIUM PAMOATE Suppliers

Global( 74)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Klong Industrial Co., Ltd
0086-519-68231162
info@klongchem.com CHINA 131 58
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871
+86 519 86305879 sales@ansciepchem.com CHINA 4242 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 3994 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9465 58
Wuhan wingroup Pharmaceutical Co., Ltd
0086-18062075862
0086-27-87819568 admin@whwingroup.com CHINA 2499 58

View Lastest Price from PYRVINIUM PAMOATE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 PYRVINIUM PAMOATE
3546-41-6
US $5.00 / KG 1KG 99% 100 Tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-06-19 PYRVINIUM PAMOATE USP/EP/BP
3546-41-6
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-04-28 Pyrvinium Pamoate
3546-41-6
US $0.00-0.00 / Kg 1KG 99.0% 500 tons Shaanxi Dideu Medichem Co. Ltd

PYRVINIUM PAMOATE Spectrum


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