Retaspimycin Hydrochloride
- CAS No.
- 857402-63-2
- Chemical Name:
- Retaspimycin Hydrochloride
- Synonyms
- Ipi-504;Ipi 504;Unii-928Q33Q049;Retaspimycin HCl;IPI-504;IPI504;IPI 504;Retaspimycin hydrochloride;IPI-504 (Retaspimycin HCl);IPI-504 (RetaspiMycin hydrochloride);17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride;18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)geldanamycin hydrochloride
- CBNumber:
- CB32496253
- Molecular Formula:
- C31H47N3O8.ClH
- Molecular Weight:
- 626.186
- MDL Number:
- MOL File:
- 857402-63-2.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≥26.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥100 mg/mL in EtOH with ultrasonic |
| form | solid |
| FDA UNII | 928Q33Q049 |
| NCI Drug Dictionary | retaspimycin hydrochloride |
Retaspimycin Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0652 | Retaspimycin(Hydrochloride) 98.35% | 857402-63-2 | 5mg | $216 | 2021-12-16 | Buy |
| ApexBio Technology | A4061 | IPI-504(Retaspimycinhydrochloride) | 857402-63-2 | 10mg | $315 | 2021-12-16 | Buy |
| ChemScene | CS-0652 | Retaspimycin(Hydrochloride) 98.35% | 857402-63-2 | 10mg | $330 | 2021-12-16 | Buy |
| ApexBio Technology | A4061 | IPI-504(Retaspimycinhydrochloride) | 857402-63-2 | 10mM(in 1mL DMSO) | $350 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611478 | Retaspimycin hydrochloride | 857402-63-2 | 5mg | $382.5 | 2021-12-16 | Buy |
Retaspimycin Hydrochloride Chemical Properties,Uses,Production
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of retaspimycin. A semi-synthetic water-soluble analogue of geldanamycin used in cancer treatment.
Biological Activity
retaspimycin hydrochloride (also known as ipi-504), a hydroquinone hydrochloride salt derivative of 17-aag, is a novel, potent and selective inhibitor of heat shock protein 90(hsp90) that binds to the amino-terminal atp/adp-binding site of hsp90. as a highly water-soluble version of 17-aag, ipi-504 (solubility > 200 mg/ml) does not need prior dissolution in organic solvents and hence can be delivered in high concentrations. once in the systemic circulation, ipi-504 is deprotonated and converted into the free base ipi-504 which is subsequently oxidized to 17-aag. ipi-504 potently inhibits proliferation in several tumor cell lines with 50% inhibition concentration ic50 values ranging from 10-40 nmol/l and has been used for the treatment of gastrointestinal stromal tumors, soft-tissue sarcomas and non-small cell lung cancer.britt erika hanson and david h vesole. retaspimycin hydrochloride (ipi-504): a novel heat shock protein inhibitor as an anticancer agent. expert opin. investi. drugs (2009) 18(9): 1375-1383david siegel, sundar jagannath, david h. vesole, ivan borello, amitabha mazumder, constantine mitsiades, jill goddard, joi dunbar, emmanuel normant, julian adams, david grayzel, kenneth c. anderson and paul richardson. a phase 1 study of ipi-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma. leukemia & lymphoma, 2011; 52(12): 2308-2315ching ching leow, jon chesebrough, karen t. coffman, christine a. fazenbaker, john gooya, david weng, steve coats, dowdy jackson, bahija jallal and yong chang. antitumor efficacy of ipi-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib. mol cancer ther 2009; 8: 2131-2141
target
HSP90
Retaspimycin Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Retaspimycin Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9338 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
View Lastest Price from Retaspimycin Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Retaspimycin Hydrochloride
857402-63-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Retaspimycin Hydrochloride
857402-63-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | Retaspimycin (Hydrochloride)
857402-63-2
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co |
-
- Retaspimycin Hydrochloride
857402-63-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Retaspimycin Hydrochloride
857402-63-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Retaspimycin (Hydrochloride)
857402-63-2
- US $1.00 / g
- 95-99%
- Career Henan Chemical Co